David S. Weinberg, MD, MSc
Fox Chase Cancer Center
333 Cottman Ave
Philadelphia, PA 19111-2497
Video: Dr. Weinberg, Chief of Gastroenterology
Colorectal Cancer Treatment at Fox Chase Cancer Center
Top Doctors 2015
Chair, Internal Medicine
Chief, Gastroenterology Section
Audrey Weg Schaus and Geoffrey Alan Weg Chair in Medical Science
Member: Cancer Risk Assessment and Prevention Research Program
Meet other members of the gastrointestinal cancer treatment team.
American Board of Internal Medicine;
I joined the staff at Fox Chase Cancer Center in 2001 as director of gastroenterology. While my gastroenterology colleagues and I see many patients with cancers of all types, we are very happy to care for the gastrointestinal needs of patients without cancer as well.
I have a special interest in cancer prevention, especially for patients who are at average risk for gastrointestinal cancers. The current methods of gastrointestinal cancer prevention tools, like colonoscopy, are very effective. However, it is very likely that the next generation of screening techniques will be substantially better. Finding new ways to increase participation in screening programs and to use molecular or genetic markers to provide more accurate estimates of risk are particular interests of mine. Hopefully, finding such markers will allow for better targeting of screening and other risk reduction strategies now and in the future.
Colorectal cancer prevention in average risk populations
Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S. Periodic screening can reduce the incidence and mortality from this disease. Unfortunately, screening is underutilized. Less than 50% of the U.S. population has been appropriately screened according to standard guidelines. The poor acceptance rate is particularly disappointing since no other common human malignancy represents such an appropriate target for cancer prevention. Effective strategies to increase screening rates, targeted towards patients or providers, have proven elusive. The major goals of our research program are the development of novel CRC risk stratification tools in average risk populations to facilitate more appropriate use of screening tests as well as investigating new methods to increase screening utilization. Several ongoing, large multi-center trials are underway that investigate new clinical platforms for CRC screening, the impact of gene-environment interaction on CRC risk stratification and the utility of patient specific informatiosn tailoring to increase CRC screening use.
MSc, Cancer Epidemiology, University of Pennsylvania, Philadelphia, PA, 1997;
MD, Cornell University Medical College, NY, NY, 1989
Internal Medicine, Beth Israel Hospital, Boston, MA
Gastroenterology, University of Pennsylvania, Philadelphia, PA;
Clinical Epidemiology, University of Pennsylvania, Philadelphia, PA
Honors and Awards
Philadelphia Magazine Top Docs 2009-2015
American Association for Cancer Research;
American Gastroenterological Association, Fellow;
The American College of Gastroenterology;
National Institutes of Health, Member, Clinical Oncology Emphasis Panel
Gastrointestinal cancer prevention and control; cancer chemoprevention; cost and clinical effectiveness studies.
- Siedler MR, Allen JI, Falck-Ytter YT, Weinberg DS. AGA Clinical Practice Guidelines: Robust, Evidence-Based Tools for Guiding Clinical Care Decisions. Gastroenterology. 2015 Aug;149(2):493-5
- Moayyedi P, Weinberg DS, Schünemann H, Chak A. Management of pancreatic cysts in an evidence-based world. Gastroenterology. 2015 Apr;148(4):692-5
- Rex DK, Schoenfeld PS, Cohen J, Pike IM, Adler DG, Fennerty MB, Lieb JG, Park WG, Rizk MK, Sawhney MS, Shaheen NJ, Wani S, Weinberg DS. Quality Indicators for Colonoscopy. Am J Gastroenterol. 2015 Jan;110(1):72-90
- Weinberg DS, Myers RE, Keenan E, Ziring B, Sifri R, Ruth K , Ross E and Manne S: Gene Environment Risk Assessment and Colorectal Cancer Screening in an Average Risk Population: A Randomized, Controlled Trial. Annals of Internal Medicine 2014; 161(8):537-45
- Horwitz E and Weinberg DS: Medicare Physician Payment Data: Is this Transparency? Ann Intern Med. 2014;161:291-292
- Weinberg DS and Schoen RE: New Advances in Colorectal Cancer Screening. Ann Intern Med. 2014;160(9):ITC5-1
- Weinberg DS, Keenan E, Ruth K, Devarajan K, Rodoletz M, Bieber EJ. A randomized trial comparing a web-based versus print-based intervention to increase CRC screening. JAMA Intern Med. 2013;173:122-9.
- Shaheen N, Denberg T, Chou R, Qaseem A, Shekelle P, Weinberg DS: Overuse of upper gastrointestinal endoscopy in acid reflux disease. Ann Intern Med. 2012;157:808-816