Karen S. Gustafson, MD, PhD
Gynecologic Cytopathology and Fine Needle Aspiration Biopsies
American Board of Pathology, Cytopathology, 2004;
American Board of Pathology, Anatomic Pathology and Clinical Pathology, 2002
I chose Fox Chase so that I could be part of an institution that focuses on cancer patient care and research. Expert pathologists within the Department of Pathology work closely with each other and with clinical and research colleagues to accomplish this goal.
My research interests are in the areas of cancer epigenetics and molecular biomarker development using cytologic samples. The Keystone Programs in Epigenetics and Stem Cell Progenitors and Personalized Risk and Prevention at Fox Chase provide unique opportunities for research collaborations.
MD, PhD (Biomedical Sciences), University of Minnesota Medical Scientist Training Program, Minneapolis, MN, 1998
Anatomic and Clinical Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 2002
Cytopathology Fellow, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 2004;
Surgical Pathology Fellow, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania Philadelphia, PA, 2003
Honors and Awards
H.T. Enterline Fellowship in Surgical Pathology Award, Hospital of the University of Pennsylvania, 2003
Cancer epigentics; Cervical cancer; Molecular Biomarker Development using cytologic samples
- Vercellotti GM, Yin HQ, Gustafson KS, Nelson RD, Jacob HS. Platelet-activating factor primes neutrophil response to agonists: Role in promoting neutrophil-mediated endothelial damage. Blood. 1988; 71: 1100-1107.
- Vercellotti GM, Wickham NWR, Gustafson KS, Yin HQ, Herbert M, Jacob HS. Thrombin-treated endothelium primes neutrophil functions: Inhibition by platelet-activating factor receptor antagonists. J. Leuk. Biol. 1989; 45: 483-490.
- Tolins JP, Melemed A, Sulciner D, Gustafson KS, Vercellotti GM. Calcium channel blockade inhibits platelet-activating factor production by human umbilical vein endothelial cells. Lipids. 1991; 26: 1218-1222.
- Gustafson KS, Vercellotti GM, Hostetter M. Molecular mimicry in Candida albicans: Role of an intergrin analogue in adhesion of the yeast to human endothelium. J. Clin. Invest. 1991; 87: 1896-1902.
- Gustafson KS, Ginder GD. Interferon-gamma induction of the human leukocyte antigen-E gene is mediated through binding of a complex containing STAT1alpha to a distinct interferon-gamma-responsive element. J. Biol. Chem. 1996; 271: 20035-20046.
- Yu GH, Gustafson KS, Pan ST, Wetherington RW. Peripheral endothelial cells are not a reliable feature for the differentiation of primary benign and malignant hepatocytic lesions in fine needle aspirates of the liver. Cytopathology. 2002; 13: 145-151.
- Gustafson KS, LiVolsi VA, Furth EE, Pasha TL, Putt ME, Baloch ZW. Peroxisome proliferator-activated receptor-gamma expression in follicular-patterned lesions of the thyroid: Caveats for the use of immunohistochemical studies. Am. J. Clin. Pathol. 2003; 120; 175-181.
- Barrett DM, Gustafson KS, Wang J, Wang SZ, Ginder GD. A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon. Mol. Cell. Biol. 2004; 24: 6194-6204.
- Gustafson KS, Furth EE, Heitjan DF, Fansler ZB, Clark DP. DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis. Cancer Cytopathol. 2004; 102: 259-268.
- Zhang J, Martins CR, Fansler ZB, Roemer KL, Kincaid EA, Gustafson KS, Heitjan DF, Clark DP. DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. Clin. Cancer Res. 2005; 11: 6544-6549.
- Furth EE, Gustafson KS, Dai CY, Gibson SL, Menard-Katcher P, Chen T, Koh J, Enders GH. Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis. Neoplasia. 2006; 8: 429-436.
- Sherman ME, Kahler J, Gustafson KS, Wang SS. “Sip Volume” as a quality indicator in liquid-based cervical cytology. Cancer Cytopathol. 2006; 108: 462-467.
- Owens CL, Rojas DN, Burroughs FH, Gustafson KS. “Low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion” is a distinct cytologic category: histologic outcomes and HPV prevalence. Am. J. Clin. Pathol. 2007; 128: 398-403.
- Gustafson KS. Locked nucleic acids can enhance the analytical performance of quantitative methylation-specific PCR. J. Mol. Diagn. 2008; 10: 33-42.
- Kahn SL, Ronnett BM, Gravitt PE, Gustafson KS. Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests. Cancer 2008; 114(1): 57-64.
- Hockstein NG, Anderson TA, Moonis G, Gustafson KS, Mirza N. Retropharyngeal lipoma causing obstructive sleep apnea: case report including five-year follow-up. Laryngoscope 2002; 112: 1603-1605.
- Anderson SR, Ginsberg GG, Gustafson KS, Ohanissian HG, Yu GH. Endoscopic ultrasound guided fine-needle aspiration diagnosis of Hodgkin’s disease in an unusual location. Diagn. Cytopathol. 2004; 31: 243-245.
- Gustafson KS, Feldman L. Cryptococcal lymphadenitis diagnosed by fine needle aspiration biopsy. Diagn. Cytopathol. 2007; 35: 103-104.
- Yu GH, Gustafson KS, Sturgis CD. Fine needle aspiration. 2002. In: Sciarra J.J., ed. Gynecology & Obstetrics. Philadelphia, Lippincott-Raven Publishers.
- Gustafson KS, Clark DP. Molecular cytopathology. 2008. In: Tubbs R. and Stoler M., eds. Cell and Tissue Based Molecular Pathology. Elsevier Science Publishers.