Faculty Summaries
Siddharth Balachandran, PhD
Siddharth Balachandran, PhD
Assistant Professor
Siddharth.Balachandran@fccc.edu
Office Phone: 215-214-1527
Lab Phone: 215-214-1528
Fax: 215-728-3574
Office: R224

Original Articles

    Current Work

  • Thapa RJ, Nogusa S, Chen P, Maki J, Lerro AT, Rall GF, Degterev A, Balachandran S. Interferon-induced RIP 1/3 kinase-dependent necrosis requires PKR and is licensed by FADD and caspases. Proc Natl Acad Sci USA. (In press).
  • Chen P., Balachandran S. Development of interferon-γ-based immunocytokines targeting renal cancer. OncoImmunol. (In press).
  • Thapa RJ, Chen P, Cheung M, Nogusa S, Pei J, Peri S, Testa JR, Balachandran S. NF-κB inhibition by bortezomib permits interferon-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Mol Cancer Ther. 2013; May 8 [Epub ahead of print].
  • Rubio D, Xu R-H, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcami A, Norbury CC, Sigal LJ. Cross-talk between the type I interferon and NF-κB pathways rescues resistance to a viral disease. Cell Host & Microbe 2013;3:701-10.
  • Garipov A, Li H, Thapa R, Balachandran S, Zhang R. NF-Y underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells. Mol Cancer Res. 2013;11:360-69.
  • Goulet M-L, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty E, Janelle V, Arguello M, Paquet M, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, Kalinke U, Qureshi S, Lamarre A, Haddad EK, Sekaly RP, Peri S, Balachandran S, Lin R, Hiscott J. Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. PLoS Pathog. 2013;9:e1003298.
  • Chen P, Nogusa S, Thapa RJ, Simmons H, Shaller C, Peri S, Adams GR, Balachandran S. Anti-CD70 immunocytokines for exploitation of interferon-γ-induced programmed necrosis in renal cell carcinoma. PLoS One. 2013;8:e61446.
  • Balachandran S, Adams GP. Interferon-γ-induced necrosis: an anti-tumor biotherapeutic perspective. J Interferon Cytokine Res. 2013;33:171-80.
  • Steen HC, Nogusa S, Thapa RJ, Basagoudanavar SH, Gill A, Merali S, Barrero CA, Balachandran S, Gamero AM. Identification of a potential regulatory role for STAT2 Serine 287 in type I interferon-induced cellular responses. J Biol Chem. 2013;288:747-58.
  • Rao S, Lee S-Y, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012;120:3764-73.
  • O'Donnell LA, Conway S, Rose RW, Nicolas E, Slifker M, Balachandran S, Rall GF. STAT1-independent control of a neurotropic measles virus challenge in primary neurons and infected mice. J Immunol. 2012;188:1915-23.
  • Balachandran S, Beg AA. Defining roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm. PLoS Pathog. 2011;7:e1002165.
  • Irrinki KM, Mallilankaraman K, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, Gandhirajan RK, Kelsen SG, Houser SR, May MJ, Balachandran S, Madesh M. Requirement of FADD, NEMO and BAX/BAK for aberrant mitochondrial function in TNFα-induced necrosis. Mol Cell Biol. 2011;31:3745-58.
  • Han Z, Nogusa S, Nicolas E, Balachandran S, Taylor J. Interferon impedes an early step in hepatitis delta virus infection. PLoS One 2011;6:e22415.
  • Thapa RJ, Basagoudanavar S, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S. NF-κB protects cells from interferon-γ-induced RIP1-dependent necroptosis. Mol Cell Biol. 2011;31:2934-46.
  • Basagoudanavar SH, Thapa RJ, Nogusa S, Wang J, Beg AA, Balachandran S. Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses. J Virol. 2011;85:2599-610.
  • Wang J, Basagoudanavar SH, Wang X, Hopewell E, Albrecht R, Garcia-Sastre A, Balachandran S, Beg AA. NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication. J Immunol. 2010;185:1720-29.
  • Selected Postdoc/Graduate Work

  • Balachandran S, Barber GN. PKR in innate immunity, cancer, and viral oncolysis. Methods Mol Biol. 2007;383:277-301.
  • Radtke AL, Delbridge LM, Balachandran S, Barber GN, O’Riordan MX. TBK1 protects vacuolar integrity during intracellular bacterial infection. PLoS Pathog. 2007;3:e29.
  • Goodman AG, Smith JA, Balachandran S, Perwitasari O, Proll SC, Thomas, MJ, Korth MJ, Barber GN, Schiff LA, Katze MG. The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. J. Virol. 2007;81:2221-30.
  • Balachandran S, Venkataraman T, Fisher PB, Barber, GN. Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7. J Immunol. 2007;178(4):2429-39.
  • Balachandran S, Thomas E, Barber GN. A FADD-dependent innate immune mechanism in mammalian cells. Nature. 2004;432:401-5.
  • Balachandran S, Barber GN. Defective translational control facilitates vesicular stomatitis virus oncolysis. Cancer Cell. 2004;5:51-65.
  • Grandvaux N, Servant MJ, tenOever B, Sen GC, Balachandran S, Barber GN, Lin R, Hiscott J. Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. J. Virol. 2002;76:5532-39.
  • Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN. Characteization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and –2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. J. Biol Chem. 2001;276:32300-12.
  • Balachandran S, Porosnicu M, Barber GN. Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis. J Virol. 2001;75:3474-9.
  • Ezelle HJ, Balachandran S, Sicheri F, Polyak SJ, Barber GN. Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A. Virology 2001;281:124-37.
  • Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR, Barber GN. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity. 2000;13:129-41.
  • Balachandran S, Barber GN. Vesicular stomatitis virus (VSV) therapy of tumors. IUBMB Life. 2000;50:135-8.
  • Heylbroeck C, Balachandran S, Servant M, DeLuca, C, Barber GN, Lin R, Hiscott J. The IRF-3 transcription factor mediates Sendai virus-induced apoptosis. J. Virol. 2000;74:3781-92.
  • Balachandran S, Roberts PC, Kipperman T, Bhalla KN, Compans RW, Archer DR, Barber GN. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. J Virol 2000;74:1513-23.
  • Balachandran S, Kim CN, Yeh WC, Mak TW, Bhalla K, Barber GN. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 1998;17:6888-902.