Faculty Summaries
Qi Kathy Cai, MD, PhD
Kathy Q. Cai, MD, PhD
Assistant Research Professor
  • Co-Director, Histopathology Facility
Office Phone: 215-214-3208
Fax: 215-728-3139
Office: W232

Research Interests

  • Develop and improve immunohistochemical (IHC; traditional and fluorescence-based) assays to detect and quantify important components of cell signaling pathways.
  • Molecular mechanism of ovarian cancer initiation and development.
  • Histopathology evaluation of rodent models of human Cancer.
Description of research projects
Selected Publications

Fox Chase Programs

  1. Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Oncogene. 2015 Aug 10. PMID:26257058
  2. Cai KQ, Wang Y, Smith ER, Smedberg JL, Yang DH, Yang WL, Xu XX. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (wv) mice. Neoplasia. 2015 Jan;17(1):89-100. PMCID:PMC4309726
  3. Lee, S.-Y., Coffey, F., Fahl, S.P., Peri, S., Rhodes, M., Cai, K.Q., Carleton, M., Hedrick, S.M., Fehling, H.J., Zúñiga-Pflücker, J.C., Kappes, D.J., and Wiest, D.L. Non-canonical mode of ERK action controls alternative αβ and γδ T lineage fates. Immunity. 2014 Dec 18;41(6):934-46. PMCID:PMC4273651
  4. Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA. Nedd9 restrains renal cystogenesis in Pkd1-/- mice. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. PMID:25139996
  5. Xu J, Kadariya Y, Cheung M, Pei J, Talarchek J, Sementino E, Tan Y, Menges CW, Cai KQ, Litwin S, Peng H, Karar J, Rauscher FJ, Testa JR. Germline mutation of bap1 accelerates development of asbestos-induced malignant mesothelioma. Cancer Res. 2014 Aug 15;74(16):4388-97. PMID:
  6. Mehra R, Zhu F, Yang DH, Cai KQ, Weaver J, Singh MK, Nikonova AS, Golemis EA, Flieder DB, Cooper HS, Lango M, Ridge JA, Burtness B. Quantification of excision repair cross-complementing group 1 and survival in p16-negative squamous cell head and neck cancers. Clin Cancer Res. 2013 Dec 1;19(23):6633-43. PMID:24088734
  7. Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, Hensley HH, Ying W, Chimmanamada D, Serebriiskii IG, Golemis EA. Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. PMID:23858461
  8. Sukhanova, A., Gorin, A., Serebriiskii, I.G., Gabitova, L., Zheng, H., Restifo, D., Egleston, B.L., Cunningham, D., Bagnyukova, T., Liu, H., Nikonova, A., Adams, G.P., Zhou, Y., Yang, D.H., Mehra, R., Burtness, B., Cai, K.Q., Klein-Szanto, A., Kratz, L.E., Kelley, R.I., Weiner, L.M., Herman, G.E., Golemis, E.A., Astsaturov, I.A.  Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGFR inhibitors via increased EGFR degradation.  Cancer Discov. 3:96-111, 2013.  PMCID: PMC3546138
  9. Li, H., Cai, Q., Wu, H., Vathipadiekal, V., Dobbin, Z.C., Li, T., Hua, X., Landen, C.N., Birrer, M.J., Sánchez-Beato, M., Zhang, R. SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.  Mol. Cancer Res. 10:1462-1472, 2012.  PMCID: PMC3501543
  10. Cai, K.Q., Caslini, C., Capo-chichi, C.D., Slater, C, Smith, E.R., Wu, H., Klein-Szanto, A., Godwin, A.K., Xu, X.  Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia. PLoS ONE 4(7):e6454, 2009.  PMC2715102
  11. Capo-chichi, C.D., Cai, K.Q., Testa, J.R., Godwin, A.K., Xu, X.X.  Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer.  Mol. Cell. Biol. 29:4766-4777, 2009.  PMC2725711
  12. Cai, K.Q., Wu, H., Klein-Szanto, A.J., Xu, X.X.  Acquisition of a second mutation of the Tp53 alleles immediately precedes epithelial morphological transformation in ovarian tumorigenicity.  Gynecol. Oncol. 114:18-25, 2009.  PMC2739736
  13. Cai, K.Q., Capo-Chichi, C.D., Rula, M.E., Yang, D.H., Xu, X.X.  Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis.  Dev. Dyn. 237:2820-2829, 2008.  PMC2739724
  14. Rula, M.E.*, Cai, K.Q.*, Moore, R., Yang, D.H., Staub, C.M., Capo-Chichi, C.D., Jablonski S.A., Howe, P.H., Smith, E.R., Xu, X.X.  Cell autonomous sorting and surface positioning in the formation of primitive endoderm in mouse blastocysts and embryoid bodies.  Genesis 45:327-338, 2007.  *Co-first authors.
  15. Yang, W.L., Cai, K.Q., Smedberg, J.L., Smith, E.R., Klein-Szanto A, Hamilton T.C., Xu, X.X.  A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumour phenotype in Wv mice.  Am. J. Pathol. 170:1325-1336, 2007.
All publications