Faculty Summaries
Dr. Kerry Campbell
Kerry S. Campbell, PhD
Associate Professor
  • Director,
Office Phone: 215-728-7761
Lab Phone: 215-728-7762
Fax: 215-728-2412
Office: R490

Recent Publications

  • Steblyanko, M., Anikeeva, N., Campbell, K.S., Keen, J.H., and Sykulev, Y. (2015) Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner. J. Biol. Chem., 290:11833-11842. PMCID: PMC4424324.
  • Frishman-Levy, L., Shemesh, A., Bar-Sinai, A., Ma, C., Ni, Z., Frenkel, S., Muench, V., Bruckmueller, H., Vokuhl, C., Debatin, K.M., Eckert, C., Stanulla, M., Schrappe, M., Campbell, K.S., Loewenthal, R., Schewe, D.M., Hochman, J., Meyer, L.H., Kaufman, D., Cario, G., Porgador, A., and Izraeli, S. (2015) Central nervous system acute lymphoblastic leukemia: role of natural killer cells. Blood, 125:3420-3431. PMCID: in process.
  • Brusilovsky, M., Radinsky, O., Cohen, L., Yossef, R., Shemesh, A., Braiman, A., Mandelboim, O., Campbell, K.S. and Porgador, A. (2015) Regulation of natural cytotoxicity receptors through interactions with heparin sulfate proteoglycans in -cis: a lesson from NKp44. Eur. J. Immunol., 45:1180-1191. PMCID: PMC4415513.
  • Anikeeva, N., Steblyanko, M., Fayngerts, S., Kopylova, N., Marshall, D., Powers, G.D., Sato, T., Campbell, K.S., and Sykulev, Y. (2014) Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity. Eur. J. Immunol., 44:2331-2339. PMCID: PMC4141007.
  • Purdy, A.K., Alvarez-Arias, D.A., Oshinsky, J., James, A.M., Serebriiskii, I., and Campbell, K.S. (2014) The AP-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor (KIR) in human NK cells. J. Immunol., 193:4675-4683. PMCID: PMC4269369.
  • MacFarlane 4th, A.W., Jillab, M., Plimack, E.R., Hudes, G.R., Uzzo, R.G., Litwin, S., Dulaimi, E., Al-Saleem, T., and Campbell, K.S. (2014) PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection. Cancer Immunol. Res., 2:320-331. PMCID: 4007343.
  • Brusilovsky, M, Radinsky, O., Yossef, R., Campbell, K.S., Porgador, A. (2014) Carbohydrate-mediated modulation of NK cell receptor function: structural and functional influences of heparan sulfate moieties expressed on NK cell surface. Front. Oncol., 4:185, PMCID: 4100077.
  • Campbell, K.S., and Hasegawa, J. (2013) NK cell biology: an update and future directions. J. Allergy Clin. Immunol., 132:536-544, PMCID: 3775709.
  • Mentlik James, A., Cohen, A.D., and Campbell, K.S. (2013) Combination therapies to enhance anti-tumor responses by NK cells. Front. Immunol., 4:481, PMCID: 3870292.
  • Brusilovsky, M., Cordoba, M., Rosental, B., Hershkovitz, O., Andrake, M.D., Pecherskaya, A., Einarson, M.B., Zhou, Y., Braiman, A., Campbell, K.S.*, and Porgador, A.* (2013) Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses. J. Immunol., 191:5256-5267. PMCID: 3836631. *Corresponding authors
  • Lucas, C.R., Cordero-Nieves, H.M., Erbe, R.S., McAlees, J.W., Bhatia, S., Hodes, R.J., Campbell, K.S., and Sanders, V.M. (2013) Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. J. Immunol., 190:723-736. PMCID: 3538926.
  • Ni, M., MacFarlane, A.W. 4th, Toft, M., Lowell, C.A., Campbell, K.S., and Hamerman, J.A. (2012) B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc. Natl. Acad. Sci. USA, 109:267-272. PMCID: 325290
  • Grier, J.T., Forbes, L.R., Monaco-Shawver, L., Oshinsky, J., Atkinson, T.P., Moody, C., Pandey, R., Campbell, K.S., and Orange, J.S. (2012) Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. J. Clin. Invest., 122:3769-3780. PMCID: 3461929.
  • Rosental, B., Hadad, U., Brusilovsky, M., Campbell, K.S., and Porgador, A. (2012) A novel mechanism for cancer cells to evade immune attack by NK cells: the interaction between NKp44 and Proliferating Cell Nuclear Antigen. OncoImmunology, 1:572-574, PMCID: 3382898.
  • Rosental, B., Brusilovsky, M., Hadad, U., Oz, D., Appel, M.Y., Afergan, F., Yossef, R., Rosenberg, L.A., Aharoni A., Cerwenka, A., Campbell, K.S., Braiman, A., and Porgador, A. (2011) Proliferating Cell Nuclear Antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44. J. Immunol., 187:5693–5702. PMCID: 3269963. PubMed
  • Campbell, K.S., and Purdy, A.K. (2011) Structure/Function of Human Killer Cell Ig-like Receptors: Lessons from Polymorphisms, Evolution, Crystal Structures, and Mutations. Immunology, 132:315-325, PMCID: 3044898. PubMed
  • Miah, S.M.S., Purdy, A.K., Rodin, N.B., MacFarlane 4th, A.W., Oshinsky, J., Alvarez-Arias, D.A., and Campbell, K.S. (2011) Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-B signaling. J. Immunol., 186:2959-2969. PMCID: 3079396 PubMed
  • Bellacosa, A., Godwin. A.K., Peri, S., Devarajan, K., Caretti, E., Vanderveer, L., Bove, B., Slater, C., Zhou, Y., Daly, M., Howard, S., Campbell, K.S., Nicolas, E., Yeung, A.T., Clapper, M.L, Crowell, J.A., Lynch, H.T., Ross, E., Kopelovich, L., and Knudson, A.G. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 and BRCA2 mutations. Cancer Prev. Res. 2010;3:48-61. PubMed
  • Purdy, A.K. and Campbell, K.S. Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol. There. 2009;8:13-22 PubMed
  • Purdy, A.K. and Campbell, K.S. SHP-2 expression negatively regulates NK cell function. J. Immunol. 2009;183:7234-7243 PubMed
  • Borghaei, H., Smith, M.R., and Campbell, K.S. Immunotherapy of Cancer. Eur. J. Pharmacol., 2009;625:41-54. PubMed
  • Hershkovitz, O., Rosental, B., Rosenberg, L.A., Jivov, S., Zilka, A., Gershoni-Yahalom, O., Brient-Litzler, E., Bedouelle, H., Navarro-Sanchez, M.E., Ho, J.W., Campbell, K.S., Rager-Zisman, B., Despres, P., and Porgador, A. NKp44 receptor mediates interaction of the envelope glycoproteins from the West-Nile and dengue viruses with natural killer cells. J. Immunol., 2009;183:2610-2621 PubMed
  • Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM. Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. J Immunol. 2008;180:6392-401. PubMed
  • MacFarlane 4th AW, Yamazaki T, Fang M, Sigal LJ, Kurosaki T, Campbell KS. Enhanced NK cell development and function in BCAP-deficient mice. Blood. 2008;112:131-40. PubMed
  • Miah, SSM, Hughes TL, Campbell KS. KIR2DL4 differentially signals downstream functions in human NK cells through distinct structural modules. J Immunol. 2008;180:2922-32. PubMed
  • Alvarez-Arias DA, Campbell KS. Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells. J Immunol. 2007;179:5281-90. PubMed
  • Chen Y, Perussia B, Campbell KS. Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. J Immunol. 2007;179:2766-73. PubMed
  • Hershkovitz O, Jivov S, Bloushtain N, Zilka A, Landau G, Bar-Ilan A, Glicklis R, Campbell KS, van Kuppevelt TH, Porgador A. Characterization of the Recognition of Tumor and Virus-Infected Cells by the Natural Cytotoxicity Receptor, NKp44. Biochemistry. 2007;46:7426-36.
  • Brando C, Mukhopadhyay S, Kovacs E, Medina R, Patel P, Campbell KS, Santoli D. Receptors and lytic mediators regulating tumor cell lysis by the leukemic killer T cell line TALL-104. J Leuk Biol. 2005;78:359-71. PubMed
  • Kikuchi-Maki A, Catina TL, Campbell KS. Cutting Edge: KIR2DL4 transduces signals into human NK cells through association with Fc receptor γ protein. J Immunol. 2005;174:3859-63. PubMed
  • Stoyanova RS, Clapper ML, Bellacosa A, Henske EP, Testa JR, Ross EA, Yeung AT, Nicolas E, Tsichlis N, Li Y-S, Linehan WM, Howard S, Campbell KS, Godwin AK, Boman B, Crowell JA, Kopelovich L, Knudson AG. Altered gene expression patterns in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther. 2004;3:1313-21.
  • Yusa S, Catina TL, Campbell KS. KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2). J Immunol. 2004;172:7385-92. PubMed
  • Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL. NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. J Immunol. 2004;172:899-6.
  • Kikuchi-Maki A, Yusa S, Catina TL, Campbell KS. KIR2DL4 is an IL-2 regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFNγ production. J Immunol. 2003;171:3415-25.
  • Kloeker S, Reed R, Popovich J, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE. Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase type 2A family (PP2Ac, PP4c, and PP6c) and analysis of the interaction of PP2Ac with alpha4 protein. Protein Expr Purif. 2003;31:19-23.
  • Yusa S, Campbell KS. Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. J Immunol. 2003;170:4539-47. PubMed
  • Yusa S, Catina TL, Campbell KS. SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. J Immunol. 2002;168:5047-57. PubMed
  • Calvo J, Vild� JM, Places L, Simarro M, Padilla O, Andreu D, Campbell KS, Aussel C, Lozano F. Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II. J Immunol. 1998;161:6022-29. PubMed
  • Bauch A, Campbell K S, Reth M. Interaction of the CD5 cytoplasmic domain with the Ca2 /calmodulin-dependent kinase II δ. Eur J Immunol. 1998;28:2167-77.
  • Campbell KS, Cooper S, Dessing M, Yates S, Buder A. Interaction of p59fyn kinase with the dynein light chain, Tctex-1, and co-localization during cytokinesis. J Immunol. 1998;161:1728-37.
  • Campbell KS, Cella M, Carretero M, L�pez-Botet M, Colonna M. Signalling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex. Eur J Immunol. 1998;28:599-09. PubMed
  • Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H. The Ig-α/Ig-β heterodimer on �-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity. 1997;7:559-70.
  • Miyazaki T, M�ller U, Campbell KS. Differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 1997;16:4217-25. PubMed
  • Campbell KS, Giorda R. The cytoplasmic domain of rat NKR-P1 receptor interacts with the N-terminal domain of p56lck via cysteine residues. Eur J Immunol. 1997;27:72-7.
  • Campbell KS, Dessing M, Cella M, Colonna M. Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. J Exp Med. 1996;184:93-100. PubMed
  • Campbell KS. Buder A, Deuschle U. Interactions between the amino-terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast. Eur J Immunol. 1995;25:2408-12.
  • Campbell KS, Bedzyk WD, Cambier JC. Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate. Molec Immunol. 1995;32:1283-94. PubMed
  • Grupp SA, Campbell K, Mitchell RN, Cambier JC, Abbas AK. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem. 1993;268:25776-79. PubMed
  • Juan M, Vilella R, Mila J, Yague J, Miralles A, Campbell KS, Friedrich RJ, Cambier J, Vives J, De Fougerolles AR, Springer T. CDw50 and ICAM-3: Two names for the same molecule. Eur J Immunol. 1993;23:1508-12. PubMed
  • Friedrich RJ, Campbell KS, Cambier JC. The γ subunit of the B cell antigen receptor is a C-terminally truncated product of the B29 gene. J Immunol. 1993;150:2814-22. PubMed
  • Clark MR, Campbell KS, Kazlauskas A, Johnson SA, Hertz M, Potter T, Pleiman C, Cambier JC. The B cell antigen receptor complex: Association of Ig-α and Ig-β with distinct cytoplasmic effectors. Science. 1992;258:123-6. PubMed
  • Campbell KS, Fuchs BA, Munson AE. The T lymphocyte is the primary cellular target for potentiation of the in vitro T-dependent IgM antibody response by the B subunit of cholera toxin. Intl J Immunopharmacol. 1992;14:111-20. PubMed
  • Clark MR, Friedrich RJ, Campbell KS, Cambier JC. Human pre-B and B cell membrane �-chains are noncovalently associated with a disulfide-linked complex containing a product of the B29 gene. J Immunol. 1991;149:2857-63.
  • Campbell KS, Hager EJ, Cambier JC. α chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J Immunol. 1991;147:1575-80. PubMed
  • Justement LB, Campbell KS, Chien NC, Cambier JC. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science. 1991;252:1839-42. PubMed
  • Campbell KS, Hager EJ, Friedrich RJ, Cambier JC. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci USA. 1991;88:3982-6. PubMed
  • Campbell KS, Cambier JC. B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide-linked, inducibly phosphorylated glycoprotein complex. EMBO J. 1990;2:441-8. PubMed
  • Fuchs BA, Campbell KS, Munson AE. Norepinephrine and serotonin content of the murine spleen: its relationship to the humoral immune response in vivo and in vitro. Cell Immunol. 1988;117:339-51. PubMed
  • Campbell KS, Munson AE. Potentiation of the in vitro T-dependent antibody response by the B subunit of cholera toxin. J Pharmacol Exp Ther. 1987;242:895-904. PubMed

Review and Methods Publications

  • Campbell, K.S., and Purdy, A.K. Structure/Function of Human Killer Cell Ig-like Receptors: Lessons from Polymorphisms, Evolution, Crystal Structures, and Mutations. Immunology 2011;in press. PubMed
  • Purdy, A.K. and Campbell, K.S. Introduction of shRNAs into human NK-like cell lines with retrovirus. Methods Mol Biol. 2010;612:223-231. PubMed
  • Miah, S.M.S. and Campbell, K.S. Expression of cDNAs in Human Natural Killer Cell Lines by Retroviral Transduction. Methods Mol Biol. 2010;612:199-208 PubMed
  • MacFarlane IV, A.W., Oesterling, J.F., and Campbell, K.S. Measuring Intracellular Calcium Signaling in Murine NK Cells by Flow Cytometry. Methods Mol Biol. 2010;612:149-157 PubMed
  • Purdy, A.K., and Campbell, K.S. Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol. Ther., 2009;8:13-22 PubMed
  • Borghaei, H., Smith, M.R., and Campbell, K.S. Immunotherapy of Cancer. Eur. J. Pharmacol., 2009;625:41-54. PubMed
  • Campbell KS. Inside Blood: Important port for SHIP-1 at Dok-3. Blood. 2007;110:3-4.
  • MacFarlane 4th AW, Campbell KS. Signal transduction in natural killer cells. Curr. Topics Microbiol Immunol. 2006;298:23-57.
  • Campbell KS. Fyn kinase. Wiley Encyclopedia of Molecular Medicine, T. Creighton, ed., John Wiley & Sons, New York, NY 2002;2:1350-3.
  • Campbell KS, Colonna M. Human natural killer cell receptors and signal transduction. Intern Rev Immunol. 2001;20:333-70.
  • Lozano F, Simarro M, Calvo J, Vil� J-M, Padilla O, Bowen MA, Campbell KS. CD5 signal transduction: positive or negative modulation of antigen receptor signalling. Crit Rev Immunol. 200;20:347-58.
  • Miyazaki T, Campbell KS. Analysis and use of mutant mice exhibiting natural killer cell defects. In Natural Killer Cell Protocols: Cellular and Molecular Methods, Campbell KS, Colonna M, Eds., Methods in Molecular Biology Series, Humana Press, Totowa, NJ, 2000.
  • Campbell KS. Signal transduction from the B cell antigen-receptor. Curr Opinion Immunol. 1999;11:256-64.
  • Campbell KS, Colonna M. DAP12: A key accessory protein for relaying signals by natural killer cell receptors. Intl J Biochem Cell Biol. 1999;31:631-6.
  • Davila DR, Davis DP, Campbell K, Cambier JC, Zigmond LA, Burchiel SW. Role of alterations in Ca2 -associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J Toxicol Environ Health. 1995;45:101-26.
  • Campbell KS, B�ckstr�m BT, Tiefenthaler G, Palmer E. CART: A conserved antigen receptor transmembrane motif. Semin Immunol. 1994;6:393-410.
  • Cambier JC, Bedzyk W, Campbell K, Chien N, Friedrich J, Harwood A, Jensen W, Pleiman C, Clark MR. The B cell antigen receptor: Structure and function of primary, secondary, tertiary and quaternary components. Immunol. Rev 1993;132:85-106.
  • Cambier JC, Campbell, KS. Membrane immunoglobulin and its accomplices: New lessons from an old receptor. FASEB J. 1992;6:3207-17.
  • Reth M, Hombach J, Wienands J, Campbell KS, Chien N, Justement LB, and Cambier JC. The B cell antigen receptor complex. Immunol Today. 1991;12:196-201.
  • Cambier JC, Campbell KS. Signal transduction by B lymphocyte receptors: structure-function relationships of membrane immunoglobulins and associated molecules. Semin Immunol. 1990;2:139-49.
  • Campbell KS, Justement LB, Cambier JC. Murine B cell antigen receptor-mediated signal transduction. In: Ligands, receptors and signal transduction in regulation of lymphocyte function. Cambier JC Ed, ASM Publications, Washington, DC 1990.


  • Campbell KS, Editor. Natural Killer Cell Protocols, Second Edition. Methods in Molecular Biology Series, Vol. 612, Humana Press/Springer Science, New York, NY, 2010.
  • Campbell, K. S., and Colonna, M., Editors. Natural Killer Cell Protocols: Cellular and Molecular Methods, First Edition. Methods in Molecular Biology Series, Vol. 121, Humana Press, Totowa, NJ, 2000.