Faculty Summaries
Wen-Chi Chang, PhD
Wen-Chi Chang, PhD
Assistant Research Professor
Office Phone: 215-728-5368
Lab Phone: 215-728-4302
Fax: 215-214-1622
Office: P2165c
Lab: P2161

Research Interests

  • Examining molecular alterations underlying colitis-associated colorectal carcinogeneisis in a mouse model of induced colitis.
  • Assessing the ability of chemopreventive agents to inhibit tumor formation in vivo and to modulate biomarker levels in select tissues.
  • Examining the feasibility of using novel image probes to detect colonic adenomas.
Description of research projects
Selected Publications

Fox Chase Programs

  1. Chang W-C, Zenser TV, Cooper HS, Clapper ML. Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines. Cancer Lett. 2013 Jun 28;334(1):62-8. PubMed PMID: 23415736; PubMed Central PMCID: PMC3770752.
  2. Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang W-C, Clapper ML, and Piazza GA.  2013.  Sulindac selectively inhibitis colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/b-catenin signaling.  Mol. Cancer Ther. 12:1848-1859, 2013. PMCID: PMC3800150.
  3. Lubert RA, Clapper ML, McCormick DL, Pereira MA, Chang W-C, Steele,VE, Fischer SM, Juliana MM, Grubbs CJ.  Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck, and mammary cancers. Oncology Reports 27:1400-1406, 2012.(Epub2012) PMID: 22307264.
  4. Foreman JE, Chang W-C, Palkar PS, Zhu B, Borland MG, Williams JL, Kramer LR, Clapper ML, Gonzalez FJ, Peters JM.  Functional characterization of peroxisome proliferator-activated receptor-b/d expression in colon cancer.  Mol. Carcinog., 50:884-900, 2011.PMCID: PMC3482838.
  5. Clapper ML, Hensley HH, Chang W-C, Devarajan K, Nguyen MT, Cooper HS. Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity. Neoplasia. 2011 Aug;13(8):685-91. PubMed PMID: 21847360; PubMed Central PMCID: PMC3156659.
  6. Hensley HH, Merkel CE, Chang W-C, Devarajan K, Cooper HS, Clapper ML. Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse. Gastrointest Endosc. 2009 Mar;69(3 Pt 2):742-9. PubMed PMID: 19251020; PubMed Central PMCID: PMC2821747.
  7. Clapper ML, Gary MA, Coudry RA, Litwin S, Chang W-C, Devarajan K, Lubet RA, Cooper HS.  5‑aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis.  Inflamm. Bowel Dis. 2008 14:1341-1347. PubMed PMID: 18452197.
  8. Cooper HS, Chang W-C, Coudry R, Gary MA, Everley L, Spittle CS, Wang H, Litwin S, Clapper ML. Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min-FCCC) mice with significantly increased numbers of colorectal adenomas. Mol Carcinog. 2005 Sep;44(1):31-41. PubMed PMID: 15937958.
  9. Chang W-C, Everley LC, Pfeiffer II GR, Cooper HS, Barusevicius A, Clapper ML.  Sulindac sulfone is most effective in modulating b‑catenin-mediated transcription in cells with mutant APC.  Ann. NY Acad. Sci., 1059:41-55, 2005. PubMed PMID: 16382042 .
  10. Hensley HH, Chang W-C, Clapper ML. Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging. Magn Reson Med. 2004 Sep;52(3):524-9. PubMed PMID: 15334570.
  11. Clapper ML, Coudry J, Chang W-C.  2004.  b‑catenin-mediated signaling: A molecular target for early chemopreventive intervention.  Mutation Res. 555: 97-105. PubMed PMID: 15476853
All publications