Wen-Chi Chang, PhD
Assistant Research Professor
Office Phone: 215-728-5368
Lab Phone: 215-728-4302
My research continues to focus on the chemoprevention and early detection of colorectal cancer. Chemoprevention is a unique and promising strategy for reducing cancer risk through the administration of synthetic or dietary compounds. Further development of this important concept relies on the identification of compounds that have low toxicity and an understanding of their mechanisms of action. Routine administration of a dietary supplement or drug that provides high-risk individuals with protection against cancer could significantly affect tumor incidence, mortality and morbidity.
It has been shown that reductions in colorectal cancer incidence can be achieved through early detection and removal of adenomas prior to their potential progression to adenocarcinomas. Unfortunately, even with colonoscopy, approximately 22% of colorectal neoplasms remain undetected. One of my research goals is to apply our understanding of basic tumor biology to the development of improved strategies for detecting early colonic lesions, especially those that escape identification using current endoscopic techniques.