Faculty Summaries
Xiaowei Chen, PhD
Xiaowei Chen, PhD
Assistant Professor
Xiaowei.Chen@fccc.edu
Office Phone: 215-214-4288
Fax: 215-728-2741
Office: W363

Publications

  • Jiang, Z, Zhou, Y, Devarajan, K, Slater, CM, Daly, MB, Chen, X. Identifying putative breast cancer-associated long intergenic non-coding RNA loci by high density SNP array analysis. Front Genet. 3: 299. 2012.
  • Gao C, Devarajan K, Zhou Y, Slater CM, Daly MB, Chen X. Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome. BMC genomics, 13: 570, 2012.
  • Brewster, B.L., Rossiello, F., French, J.D., Edwards, S.L., Wong, M.,Wronski, A., Whiley, P., Waddell, N., Chen, X., Bove, B.; kConFab, Hopper, J.L., John, E.M., Andrulis, I., Daly, M., Volorio, S., Bernard, L., Peissel, B., Manoukian, S., Barile, M., Pizzamiglio, S., Verderio, P., Spurdle, A.B., Radice, P., Godwin, A.K., Southey, M.C., Brown, M.A., Peterlongo, P. Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that induces a functional miRNA-103 target site. Human Mutation, 2012.
  • Chen, X., Kistler, J.L., and Godwin, A.K. BRCA1-associated proteins: novel targets for breast cancer radiation therapy. In: Columbus F., editor. Radiation therapy for breast cancer. Hauppauge, NY: Nova Science Publishers, Inc., p. 121-41, 2010.
  • Chen, X., Weaver, J., Bove, B.A., Vanderveer, L.A., Weil, S.C., Miron, A., Daly, M.B., Godwin, A.K. Allelic Imbalance in BRCA1 and BRCA2 Gene Expression Is Associated with an Increased Breast Cancer Risk. Hum Mol Genet, 17: 1336-1348, 2008.
  • Chen, X., Arciero, C. A., and Godwin, A. K. BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance. Expert Rev Anticancer Ther, 6: 187-196, 2006.
  • Chen, X., Truong, T.-T. N., Weaver, J., Bove, B. A., Cattie, K., Armstrong, B. A., Daly, M. B., and Godwin, A. K. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. Human Mutation, 27: 427-435, 2006.
  • Chen, X., Arciero, C. A., Wang, C., Broccoli, D., and Godwin, A. K. BRCC36 is essential for IR-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Res, 66: 5039-5046, 2006.
  • Guo, S., Hakimi, M. A., Baillat, D., Chen, X., Farber, M. J., Klein-Szanto, A. J., Cooch, N. S., Godwin, A. K., and Shiekhattar, R. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res, 65: 3011-3016, 2005.
  • Schilder, R. J., Sill, M. W., Chen, X., Darcy, K. M., Decesare, S. L., Lewandowski, G., Lee, R. B., Arciero, C. A., Wu, H., and Godwin, A. K. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin Cancer Res, 11: 5539-5548, 2005.
  • Dong, Y., Hakimi, M. A., Chen, X., Kumaraswamy, E., Cooch, N. S., Godwin, A. K., and Shiekhattar, R. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell, 12: 1087-1099, 2003.
  • Chen, X., Garner, S. C., Quarles, L. D., and Anderson, J. J. B. Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiation. J Nutr Biochem, 14: 342-349, 2003.
  • Chen X, Garner SC, Anderson JJ. Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun, 295: 417-22, 2002.
  • Chen X, Anderson JJB. Efects of phytoestrogens on bone cells: genomic and nongenomic mechanisms. In: Gilani GS, Anderson JJB, editors. Phytoestrogens and Health. Champaign, IL: AOCS Press; p. 248-59, 2002.
  • Chen X, Anderson JJ. Isoflavones and bone: animal and human evidence of efficacy. J Musculoskelet Neuronal Interact, 2: 352-9, 2002.
  • Anderson, J. J. B., Chen, X., Boass, A., Symons, M., Kohlmeier, M., Renner, J. B., and Garner, S. C. Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. J Am Coll Nutr, 21: 388-393, 2002.
  • Chen, X. and Anderson, J. J. B. Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptor-dependent pathway. Nutr Cancer, 41: 165-171, 2001.
  • Lee YS, Chen X, Anderson JJB. Physiological concentrations of genistein stimulate the proliferation and protect against free radical-induced oxidative damage of MC3T3-E1 osteoblast-like cells. Nutrition Res, 21: 1287-98, 2001.
  • Brayboy JR, Chen X, Lee YS, Anderson JJB. The protective effects of Ginkgo biloba extract (EGb 761) against free radical damage to osteoblast-like bone cells (MC3T3-E1) and the proliferative effects of EGb 761 on these cells. Nutrition Res, 21: 1275-85, 2001.