Faculty Summaries
Jonathan Chernoff, PhD
Jonathan Chernoff, MD, PhD
Professor
  • SVP
  • Chief Scientific Officer
  • Stanley P. Reimann Chair in Oncology Research
  • Co-Leader, Cancer Biology
  • Co-Leader, Epigenetics and Progenitor Cells Keystone
Jonathan.Chernoff@fccc.edu
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Office: W455
Lab: W450-456
Ongoing Research Support
Principal InvestigatorTitle and DescriptionAffiliation, Dates

Seiden, M

P30 CA006927 Comprehensive Cancer Center Program at Fox Chase

This grant is in a one year extension.

The major goal of this Cancer Center Support Grant is to provide partial salary support for professional personnel, including senior and program leadership, administration, planning and evaluation, and developmental funds, as well as support for 5 established peer-reviewed Research Programs and 16 Shared Facilities. This grant includes a supplement for the American Russian Cancer Alliance (ARCA).

NIH
Role: Program Leader

09/10/2005 – 6/30/2011

Saha, S

W81XWH-10-1-1005; Role of PTP1B in HER2 Signaling in Breast Cancer

The major goals of this project are: 1) To identify the key pro-oncogenic PTP1B regulated signaling pathways in ErbB2-transformed mammary epithelial cells; and 2) To validate the role of identified PTP1B substrates in bringing about the proliferative and morphogenetic effects of ErbB2 signaling in breast cancer. Dr. Chernoff serves as a Mentor on this grant.

Army
Role: Mentor

09/30/2010 – 09/29/2013

Chernoff, J

R01 CA142928; Role of PTP1B in HER2 Signaling in Breast Cancer

p21-Activated Kinases as New Therapeutic Targets in Neurofibromatosis Type 1 The major goals of this project are 1) What are the key substrates of group A Paks in mast cells that affect cell motility? 2) What is the role of group A Paks in NF1-related signaling in Schwann cells? and 3) What is the cellular and molecular basis for Pak signaling in NF1-related pathology in vivo?

NIH
Role: Principal Investigator

07/01/2010 – 12/31/2014

Chow, B

W81XWH-10-1-0092; Role of p21-Activated Protein Kinases in Neurofibromatosis 2

The major goal of this project is to determine if inhibiting group A Paks influences NF2-related pathology. Dr. Chernoff serves as a Mentor on this grant.

Army
Role: Mentor

02/01/2010 – 01/31/2012

Chernoff, J

W81XWH-10-1-0181; Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1

The major goals of this project are to: 1) Create iPS cells from Nf1+/- keratinocytes; 2) Repair the damaged Nf1 allele; 3) Convert the iPS cells to hematopoietic precursors; and 4) Transplant NF1 mouse with iPS-derived Nf1+/+ or Nf1+/- cells.

Army
Role: Principal Investigator

05/01/2010 – 04/30/2012

Li, Vanderbilt

R01 NS066927; Pathophysiology of Conduction Block in HNPP

This project is a subcontract to Vanderbilt University Medical Center.

NIH
Role: Principal Investigator

03/15/2010 – 02/28/2015

Chernoff, J

08-0049; p21-Activated Kinase-1 as a Novel Therapeutic Target in Asthma

The major goals of this SPAR project are: 1) To determine how Pak1 activity is regulated during mast cell activation; 2) To identify the substrates of Pak1 in mast cells that mediate its effects on degranulation andcytokine secretion; 3) To establish if loss of Pak1 function in mast cell affects airways responsiveness in mice; and 4) To determine if chemical Pak1 inhibitors reduce mast cell function.

American Asthma Foundation
Role: Principal Investigator

07/01/2008 – 06/30/2011

Chernoff, J

IRG-92-027-17; ACS Institutional Research Grant

This grant is in a one year extension.

This is an Institutional Grant from the American Cancer Society that provides start-up funds for promising junior investigators to initiate innovative laboratory, clinical and translational research.

ACS
Role: Principal Investigator

01/01/2008 – 12/31/2011

Chernoff, J

R01 CA117884; Signaling By p21-Activated Protein Kinases

The major goals of this project are: 1) How does Pak1 regulate centrosome function and genome stability?; 2) Role of Pak in ERK activation: what are its mechanisms of action?; and 3) How does loss of Pak signaling influence tumorigenesis?

NIH
Role: Principal Investigator

09/22/2006 – 07/31/2011