Faculty Summaries
Jonathan Chernoff, PhD
Jonathan Chernoff, MD, PhD
  • Senior Vice President
  • Deputy Director
  • Chief Scientific Officer
  • Stanley P. Reimann Chair in Oncology Research
  • Co-Leader, Cancer Biology
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Fax: 215-728-3616
Office: W455
Lab: W422, W450-451

Research Interests

  • Proliferative signal transduction
  • Regulation of neoplastic growth by protein kinases and phosphatases
  • Regulation and role of p21-activated kinases in cancer
  • Hippo tumor suppressor pathway
Description of research projects
Selected Publications
  1. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J. Oncogene. 2015 Aug 10. doi: 10.1038/onc.2015.278.  PMID:26257058
  2. Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 2015 May 7;125(19):2995-3005. doi: 10.1182/blood-2014-10-604504. Epub 2015 Mar 30. PubMed PMID: 25824689; PubMed Central PMCID: PMC4424419.
  3. Regulation of mammalian Ste20 (Mst) kinases. Rawat SJ, Chernoff J. Trends in biochemical sciences. 2015; 40(3):149-56. NIHMSID: NIHMS655499 PubMed PMID:
    25665457 PMCID:PMC4340714
  4. Chow HY, Dong B, Duron SG, Campbell DA, Ong CC, Hoeflich KP, Chang LS, Welling DB, Yang ZJ, Chernoff J. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015 Feb 10;6(4):1981-94. PubMed PMID: 25596744; PubMed Central PMCID: PMC4385830
  5. Kelly ML, Astsaturov A, Rhodes J, Chernoff J. A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Dev Cell. 2014 May 12;29(3):350-9. doi: 10.1016/j.devcel.2014.04.003. PubMed PMID: 24823378; PubMed Central PMCID: PMC4073496.
  6. PAK signalling during the development and progression of cancer. Radu M, Semenova G, Kosoff R, Chernoff J. Nature reviews. Cancer. 2014; 14(1):13-25. NIHMSID: NIHMS556174 PubMed PMID: 24505617 PMCID: PMC4115244
  7. Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.
    Arias-Romero LE, Villamar-Cruz O, Huang M, Hoeflich KP, Chernoff J. Cancer research. 2013; 73(12):3671-82. NIHMSID: NIHMS464433 PubMed PMID: 23576562 PMCID: PMC3687032
  8. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. Radu M, Rawat SJ, Beeser A, Iliuk A, Tao WA, et al. The Journal of biological chemistry. 2013; 288(29):21117-25. PubMed PMID:23760270 PMCID:
  9. The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. Rawat SJ, Creasy CL, Peterson JR, Chernoff J. The Journal of biological chemistry. 2013; 288(12):8762-71.PubMed PMID:23386615 PMCID:PMC3605693
  10. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, et al. Cancer research. 2012; 72(22):5966-75. NIHMSID: NIHMS407835 PubMed PMID: 22983922 PMCID: PMC3500416
  11. Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. Yip SC, Cotteret S, Chernoff J.
    Journal of cell science. 2012; 125(Pt 2):310-6. PubMed PMID: 22266903
    PMCID: PMC3283870
  12. Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. De la Mota-Peynado A, Chernoff J, Beeser A. The Journal of biological chemistry. 2011; 286(15):13603-11. PubMed PMID:21317288 PMCID:PMC3075705
All publications