Faculty Summaries
Jonathan Chernoff, PhD
Jonathan Chernoff, MD, PhD
  • Senior Vice President
  • Deputy Director
  • Chief Scientific Officer
  • Stanley P. Reimann Chair in Oncology Research
  • Co-Leader, Cancer Biology
Office Phone: 215-728-5319
Lab Phone: 215-728-5320
Fax: 215-728-3616
Office: W455
Lab: W422, W450-451
  • Laboratory Overview

    The process of neoplastic transformation can be conceptually divided into two components. The first of these, proliferative transformation, refers to the ability of transformed cells to bypass growth suppression signals, surviving and dividing when normal cells would not. The second, morphologic transformationrefers to loss of normal cytoskeletal architecture, often accompanied by decreased adhesion and acquisition of the ability to invade surrounding tissues. These two fundamental properties are intimately linked to one another, although experimentally they can be dissected apart through the use of gain-of-function and loss-of-function manipulation of signaling molecules. The overall focus this research is in uncovering the roles of protein phosphorylation in governing these two fundamental aspects of cancer biolog5.