Faculty Summaries
Margie L. Clapper, PhD
Margie L. Clapper, PhD
  • Co-Leader, Cancer Prevention and Control
Office Phone: 215-728-4301
Lab Phone: 215-728-4302
Fax: 215-214-1622
Office: P2043
Lab: P2161

Research Interests

  • Genetic mechanisms underlying the development of spontaneous and colitis-associated colorectal cancer
  • Gene-environment interactions that contribute to racial and gender-based differences in lung cancer susceptibility
  • Characterization of promising cancer preventive agents and their mechanisms of action in tumor prone mouse models
  • Novel image-based strategies for the earliest detection of preneoplasia
Description of research projects
Selected Publications

Fox Chase Programs

Extramural Affiliations

  1. Salaün, M, Peng J, Hensley HH, Roder N, Flieder DB, Houlle-Crépin S, Abramovici-Roels O, Sabourin J-C, Thiberville L, Clapper ML. MMP-13 in-vivo molecular imaging reveals early expression in lung adenocarcinoma. PLoS One. 2015 Jul20;10(7):e0132960.  PubMed PMID: 26193700 [PubMed - in process]; PubMed Central PMCID: PMC4508003.
  2. Chang WC, Zenser TV, Cooper HS, Clapper ML. Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines. Cancer Lett. 2013 Jun 28;334(1):62-8. PubMed PMID: 23415736; PubMed Central PMCID: PMC3770752.
  3. Peng J, Xu X, Mace BE, Vanderveer LA, Workman LR, Slifker MJ, Sullivan PM, Veenstra TD, Clapper ML.  Estrogen metabolism within the lung and its modulation by tobacco smoke. Carcinogenesis. 2013 Apr;34(4):909-15. PubMed PMID: 23276798; PubMed Central PMCID: PMC3616670.
  4. Clapper ML, Hensley HH, Chang W-C, Devarajan K, Nguyen MT, Cooper HS. Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity. Neoplasia. 2011 Aug;13(8):685-91. PubMed PMID: 21847360; PubMed Central PMCID: PMC3156659.
  5. Shatalova EG, Klein-Szanto AJ, Devarajan K, Cukierman E, Clapper ML. Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Jan;4(1):107-15. PubMed PMID: 21205741; PubMed Central PMCID: PMC3043603.
  6. Meireles SI, Esteves GH, Hirata R Jr, Peri S, Devarajan K, Slifker M, Mosier SL, Peng J, Vadhanam MV, Hurst HE, Neves EJ, Reis LF, Gairola CG, Gupta RC, Clapper ML.  Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue. Cancer Prev Res (Phila). 2010 Jun;3(6):707-17. PubMed PMID: 20515954; PubMed Central PMCID: PMC2896420.
  7. Hensley HH, Merkel CE, Chang WC, Devarajan K, Cooper HS, Clapper ML. Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse. Gastrointest Endosc. 2009 Mar;69(3 Pt 2):742-9. PubMed PMID: 19251020; PubMed Central PMCID: PMC2821747.
  8. Egleston, BL, Meireles SI, Flieder DB, and Clapper ML.  Population-based trends in lung cancer incidence in women.  Seminars in Oncology. 2009 36: 506-515.  (Lead article in an edition devoted to lung cancer in women.) PubMed PMID: 19995642; PubMed Central PMCID: PMC2846780.
  9. Clapper, ML, Gary MA, Coudry RA, Litwin S, Chang W-C L, Devarajan K, Lubet RA, Cooper HS.  5‑aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis.  Inflamm. Bowel Dis. 2008 14:1341-1347. PubMed PMID: 18452197.
  10. Cooper HS, Chang WC, Coudry R, Gary MA, Everley L, Spittle CS, Wang H, Litwin S, Clapper ML. Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min-FCCC) mice with significantly increased numbers of colorectal adenomas. Mol Carcinog. 2005 Sep;44(1):31-41. PubMed PMID: 15937958.
  11. Hensley HH, Chang WC, Clapper ML. Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging. Magn Reson Med. 2004 Sep;52(3):524-9. PubMed PMID: 15334570.
  12. Clapper, M. L., J. Coudry and W-C. L. Chang.  2004.  b‑catenin-mediated signaling: A molecular target for early chemopreventive intervention.  Mutation Res. 555: 97-105. PubMed PMID: 15476853.
All publications