Faculty Summaries
Margie L. Clapper, PhD
Margie L. Clapper, PhD
  • Co-Leader, Cancer Prevention and Control
Office Phone: 215-728-4301
Fax: 215-214-1622
Office: P2043
Lab: P2157
Preclinical Chemoprevention: Biomarkers of Cancer Risk and Molecular Targets for Early Intervention

The overall goal of this program is to develop novel, efficacious therapeutic regimens for the prevention of human cancer. The major focus continues to be on the identification of early molecular alterations that may serve as biomarkers of cancer risk and targets for therapeutic intervention in colorectal and lung carcinogenesis.

Current efforts focus on four areas of basic research, which include: 1) identification of molecular targets for early intervention; 2) selection of the most promising chemopreventive agents for analysis and elucidation of their mechanism of action; 3) establishment of biomarkers of cancer risk to facilitate the selection of those asymptomatic high-risk individuals who would benefit most from a preventive intervention; and 4) the development of validated intermediate endpoints of carcinogenesis and their use as biomarkers of therapeutic response. Application of state-of-the-art genomic and imaging technology to the analysis of well-defined mouse models continues to provide unique insight into the molecular basis of the carcinogenic process and potential strategies for tumor inhibition.

Description of research projects
Selected Publications
  1. Meireles SI, Esteves GH, Hirata R Jr, Peri S, Devarajan K, Slifker M, Mosier SL, Peng J, Vadhanam MV, Hurst HE, Neves EJ, Reis LF, Gairola CG, Gupta RC, Clapper ML. Early changes in gene expression induced by tobacco smoke: evidence for the importance of estrogen within lung tissue. Cancer Prev Res (Phila). 2010 Jun;3(6):707-17. Epub 2010 Jun 1. PubMed
  2. Hensley HH, Merkel CE, Chang W-CL, Devarajan K, Cooper HS, Clapper ML. Endoscopic imaging and size estimation of colorectal adenomas in the Multiple Intestinal Neoplasia mouse. Gastrointest Endosc. 2009;69(3)Suppl:742-9. PubMed
  3. Shatalova EG, Klein-Szanto AJP, Devarajan K, Cukierman E, Clapper ML. Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Jan;4(1):107-15. PubMed
  4. Chang W-CL, Coudry RA, Clapper ML, Zhang X, Williams K, Spittle CS, Li T, Cooper HS. Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis. 2007;28:2375-81. PubMed
  5. Cooper HS, Chang W-C, Coudry R, Gary M, Everley L, Spittle CS, Wang H, Litwin S, Clapper ML. Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min-FCCC) mice with significantly increased numbers of colorectal adenomas. Mol Carcinog. 2005; 44:31-41. PubMed
All publications