Faculty Summaries
Margie L. Clapper, PhD
Margie L. Clapper, PhD
Professor
  • Co-Leader, Cancer Prevention and Control
Margie.Clapper@fccc.edu
Office Phone: 215-728-4301
Fax: 215-214-1622
Office: P2043
Lab: P2157

Original Articles

  • Peng J, Xu X, Mace BE, Vanderveer LA, Workman LR, Slifker MJ, Sullivan PM, Veenstra TD, Clapper ML. Estrogen metabolism within the lung and its modulation by tobacco smoke. Carcinogenesis 2013;34:909-15.
  • Chang W-C, Zenser TV, Cooper HS, Clapper ML. Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines. Cancer Letters 2013;334:62-8.
  • Lubet RA, Clapper ML, McCormick DL, Pereira MA, Chang W-CL, Steele VE, Fischer SM, Juliana MM, Grubbs CJ. Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers. Oncology Reports 2012;27:1400-06.
  • Foreman JE, Chang WC, Palkar PS, Zhu B, Borland MG, Williams JL, Kramer LR, Clapper ML, Gonzalez FJ, Peters JM. Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer. Mol Carcinog. 2011 Nov;50(11):884-900. doi: 10.1002/mc.20757. Epub 2011 Mar 11.
  • Clapper ML, Hensley HH, Chang WC, Devarajan K, Nguyen MT, Cooper HS. Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity. Neoplasia. 2011 Aug;13(8):685-91.
  • Meireles SI, Esteves GH, Hirata R Jr, Peri S, Devarajan K, Slifker M, Mosier SL, Peng J, Vadhanam MV, Hurst HE, Neves EJ, Reis LF, Gairola CG, Gupta RC, Clapper ML. Early changes in gene expression induced by tobacco smoke: evidence for the importance of estrogen within lung tissue. Cancer Prev Res (Phila). 2010 Jun;3(6):707-17. Epub 2010 Jun 1.
  • Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT. Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res. 2010;3:48-61.
  • Foreman JE, Sorg JM, McGinnis KS, Rigas B, Williams JL, Clapper ML, Gonzalez FJ, Peters JM. Regulation of peroxisome proliferator-activated receptor-β/δ by the APC/β catenin pathway and nonsteroidal anti-inflammatory drugs. Mol. Carcinog. 2009;48:942-52.
  • Hensley HH, Merkel CE, Chang W-CL, Devarajan K, Cooper HS, Clapper ML. Endoscopic imaging and size estimation of colorectal adenomas in the Multiple Intestinal Neoplasia mouse. Gastrointest Endosc. 2009;69(3)Suppl:742-9.
  • Clapper ML, Gary, MA, Coudry RA, Litwin S, Chang W-CL, Devarajan K, Lubet RA, Cooper HS. 5 aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2008;14:1341-7.
  • Lee K-M, Kang D, Clapper ML, and members of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens. CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. Cancer Epidemiol Biomark Prev. 2008;17:1120-6.
  • Aiyer HS, Vadhanam MV, Stoyanova R, Caprio GD, Clapper ML, Gupta RC. Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes. Int J Mol Sci. 2008;9:327-41.
  • Caretti E, Devarajan K, Coudry R, Ross E, Clapper ML, Cooper H, Bellacosa A. Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection. J Cell Biochem. 2008;103:556-63.
  • Chang W-CL, Coudry RA, Clapper ML, Zhang X, Williams K, Spittle CS, Li T, Cooper HS. Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis. 2007;28:2375-81.
  • Patel BB, Li X-M, Dixon MP, Blagoi EL, Seeholzer SH, Chen Y, Miller CG, He YA, Tetruashvily M, Chaudhry AH, Ke E, Xie J, Cooper H, Bellacosa A, Clapper ML, Boman BM, Zhang T, Litwin S, Ross E, Conrad P, Crowell JA, Kopelovich L, Knudson A, Yeung AT. Searchable high-resolution 2D gel proteome of the human colon crypt. J Proteome Res. 2007;6:2232-8.
  • Coudry RA, Meireles SI, Stoyanova R, Cooper HS, Carpino A, Wang X, Engstrom P, Clapper ML. Successful application of microarray technology to microdissected formalin-fixed, paraffin-embedded tissue. J Mol Diagn. 2007;9:70-9.
  • Arif JM, Dresler C, Clapper ML, Gairola CG, Srinivasan C, Lubet RA, Gupta RC. Lung DNA adducts detected in human smokers are unrelated to typical polyaromatic carcinogens. Chem Res Toxicol. 2006;19:295-9.
  • Chang W-CL, Everley LC, Pfeiffer II, GR, Cooper HS, Barusevicius A, Clapper ML. Sulindac sulfone is most effective in modulating β catenin-mediated transcription in cells with mutant APC. Ann NY Acad Sci. 2005;1059:41-55.
  • Cooper HS, Chang W-C, Coudry R, Gary M, Everley L, Spittle CS, Wang H, Litwin S, Clapper ML. Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min-FCCC) mice with significantly increased numbers of colorectal adenomas. Mol Carcinog. 2005; 44:31-41.
  • Lakshmi VM, Clapper ML, Chang W-C, Zenser TV. Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline. Chem Res Toxicol. 2005;18:528-35.
  • Stoyanova R, Clapper ML, Bellacosa A, Henske EP, Testa JR, Ross EA, Yeung AT, Nicolas E, Tsichlis N, Li Y-S, Linehan WM, Howard S, Campbell KS, Godwin AK, Boman BM, Crowell JA, Kopelovich L, Knudson AG. Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther. 2004;3:1313-21.
  • Vineis P, Veglia F, Anttila S, Benhamou S, Clapper ML, Dolzan V, Ryberg D, Hirvonen A, Kremers P, Le Marchand L, Pastorelli R, Rannug A, Romkes M, Schoket B, Strange RC, Garte S, Taioli E. CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions. Biomarkers. 2004;9:298-305.
  • Smits KM, Benhamou S, Garte S, Weijenberg MP, Alamanos Y, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Boffetta P, Bouchardy C, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, and members of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. Int J Cancer. 2004;110: 266-70.
  • Hensley HH, Chang W-C, Clapper ML. Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging. Magn Reson Med. 2004;52:524-9.
  • Upson JJ, Stoyanova R, Cooper HS, Patriotis C, Ross EA, Boman B, Clapper ML, Knudson AG, Bellacosa A. Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection. J Cell Physiol. 2004;201:366-73.
  • Stoyanova R, Upson JJ, Patriotis C, Ross EA, Henske EP, Datta K, Boman B, Clapper ML, Knudson AG, Bellacosa A. Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays. J Cell Physiol. 2004;201:359-65.
  • Le Marchand L, Guo C, Benhamou S, Bouchardy C, Cascorbi I, Clapper ML, Garte S, Haugen A, Ingelman-Sundberg M, Kihara M, Rannug A, Ryberg D, Stucker I, Sugimura H, Taioli E. Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States). Cancer Causes and Control. 2003;14:339-46.
  • Hung RJ, Boffetta P, Brockmöller J, Butkiewicz D, Cascorbi I, Clapper ML, Garte S, Haugen A, Hirvonen A, Anttila S, Kalina I, Le Marchand L, London SJ, Rannug A, Romkes M, Salagovic J, Schoket B, Gaspari L, Taioli E. CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis. Carcinogenesis. 2003;24:875-82.
  • Mirvish SS, Haorah J, Zhou L, Hartman M, Morris CR, Clapper ML. N-nitroso compounds in the rat gastrointestinal tract and the feces of mice with induced colitis or fed hot dogs or beef. Carcinogenesis. 2003;24:595-603.
  • Taioli E, Gaspari L, Benhamou S, Boffetta P, Brockmöller J, Butkiewicz D, Cascorbi I, Clapper ML, Dolzan V, Haugen A, Hirvonen A, Husgafvel-Pursiainen K, Kalina I, Kremers P, Le Marchand L, London S, Rannug A, Romkes M, Schoket B, Seidegard J, Strange RC, Stucker I, To Figuares J, Garte S. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years. Int J Epidemiol. 2003;32:60-3.
  • Vineis P, Veglia F, Benhamou S, Butkiewicz D, Cascorbi I, Clapper ML, Dolzan V, Haugen A, Hirvonen A, Ingelman-Sundberg M, Kihara M, Kiyohara C, Kremers P, Le Marchand L, Ohshima S, Pastorelli R, Rannug A, Romkes M, Schoket B, Shields P, Strange RC, Stucker I, Sugimura H, Garte S, Gaspari L, Taioli E. CYP1A1 T3801 C polymorphism and lung cancer: A pooled analysis of 2,451 cases and 3,358 controls. Int J Cancer. 2003;104:650-7.
  • Mirvish SS, Haorah J, Zhou L, Clapper ML, Harrison KL, Povey AC. Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: possible etiologic agents for colon cancer. J Nutr. 2002;132:3526S-9S.
  • Benhamou S, Lee WJ, Alexandrie A-K, Boffetta P, Bouchardy C, Butkiewicz D, Brockmöller J., Clapper ML, Daly A, Dolzan V, Ford J, Gaspari L, Haugen A, Hirvonen A, Husgafvel-Pursiainen K, Ingelman-Sundberg M, Kalina I, Kihara M, Kremers P, Le Marchand L, London SJ, Nazar-Stewart V, Onon-Kihara M, Rannug A, Romkes M, Ryberg D, Seidegard J, Shields P, Strange RC, Stucker I, To-Figueras J, Brennan P, Taioli E. Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. Carcinogenesis. 2002;23:1343-50.
  • Ruggeri BA, Robinson C, Angeles T, Wilkinson J, IV, Clapper ML. The chemopreventive agent oltipraz possesses potent anti-angiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth. Clin Cancer Res. 2002;8:267-74.
  • Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H,, Autrup JL, Baranova H, Bathum L, Benhamou S, Boffetta P, Bouchardy C, Breskvar K, Brockmöller J, Cascorbi I, Clapper ML, and members of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens. Metabolic gene polymorphism frequencies in normal control populations. Cancer Epidemiol Biomark Prev. 2001;10:1239-48.
  • Cooper HS, Everley L, Chang W-C, Pfeiffer G, Lee B, Murthy S, Clapper ML. The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis. Gastroenterology. 2001;121:1407-16.
  • Szarka CE, Yao K-S, Pfeiffer GR, Balshem AM, Litwin S, Frucht H, Goosenberg EB, Engstrom PF, Clapper ML, O'Dwyer PJ. Chronic dosing of oltipraz in people at increased risk for colorectal cancer. Cancer Detect Prev. 2001;25:352-61.
  • Dresler CM, Fratelli C, Babb J, Everley L, Evans AA, Clapper ML. Gender differences in genetic susceptibility to lung cancer. Lung Cancer. 2000;30:153-60.
  • Taioli, E. and members of the Collaborative Group on Genetic Susceptibility to Environmental Carcinogens, including Clapper, M. L. International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens. Letter to the Editor. Cancer Epidemiol Biomarkers Prev. 1999;8:727-8.
  • Liu S-C,Hu Y, Sauter ER, Clapper ML, Chen SY, Lanfranchi HE, Engstrom PF, Klein-Szanto AJP. Image analysis of p53 and cyclin D1 expression in premalignant lesions of the oral mucosa. Analyt Quant Cytol Histol. 1999;21:166-73.
  • Clapper ML, Adrian RH, Pfeiffer GR, Kido K, Everley L, Cooper HS, Murthy S. Depletion of colonic detoxication enzyme activity in mice with dextran sulphate sodium-induced colitis. Aliment Pharmacol Ther. 1999;13:389-96.
  • Townsend AJ, Fields WR, Doss AJ, Clapper ML, Doehmer J, Morrow CS. Modeling the chemoprotective functions of glutathione S-transferases in cultured cell lines by heterologous expression. Drug Metabolism Reviews. 1998;31:43-69.
  • Wilkinson J, IV, Radjendirane V, Pfeiffer G, Jaiswal AK, Clapper ML. Disruption of c-Fos leads to increased expression of NAD(P)H:quinone oxidoreductase1 and glutathione S-transferase. Biochem Biophys Res Comm. 1998;253:855-8.
  • Liu SC, Sauter ER, Clapper ML, Feldman RS, Levin L, Chen SY, Yen T, Ross E, Engstrom PF, Klein-Szanto AJP. Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol Biomarkers Prev. 1998;7:597-603.
  • Clapper ML, Szarka CE. Glutathione S-transferases – biomarkers of cancer risk and chemopreventive response. Chemico-Biol Interactions. 1998;111-112:377-88.
  • Mitsunaga S-I, Clapper ML, Litwin S, Watts P, Bauer B, Klein-Szanto AJP. Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene. J Cell Biochem Suppl. 1997;28/29:81-9.
  • Zhou T, Evans AA, London WT, Xia X, Zou H, Shen F-M, Clapper ML. Glutathione S-transferase expression in HBV-associated human hepatocellular carcinogenesis. Cancer Res. 1997;57:2749-53.
  • Clapper ML, Szarka CE, Pfeiffer GR, Graham TA, Balshem A, Litwin S, Goosenberg EB, Frucht H, Engstrom PF. Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity. Clin Cancer Res. 1997;3:25-30.
  • O'Dwyer PJ, Szarka CE, Yao K-S, Halbherr TC, Pfeiffer GR, Green F, Gallo JM, Brennan J, Frucht H, Goosenberg EB, Hamilton TC, Litwin S, Balshem AM, Engstrom PF, Clapper ML. Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. J Clin Invest. 1996;98:1210-7.
  • Clapper ML, Wood M, Leahy K, Lang D, Miknyoczki S, Ruggeri B. Chemopreventive activity of oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. Carcinogenesis. 1995;16:2159-65.
  • Szarka CE, Pfeiffer GR, Hum ST, Everley LC, Balshem AM, Moore DF, Litwin S, Goosenberg EB, Frucht H, Engstrom PF, Clapper ML. Glutathione S-transferase activity and glutathione S-transferase µ expression in subjects with risk for colorectal cancer. Cancer Res. 1995;55:2789-93.
  • McGlynn KA, Rosvold EA, Lustbader ED, Hu Y, Clapper ML, Zhou T, Wild CP, Xia X-L, Baffoe-Bonnie A, Ofori-Adjei D, Chen G-C, London WT, Shen F-M, Buetow KH. Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. Proc Natl Acad Sci USA. 1995;92:2384-7.
  • Clapper ML, Everley LC, Strobel LS, Townsend AJ, Engstrom PF. Coordinate induction of glutathione S-transferase α, µ, and π expression in murine liver following a single administration of oltipraz. Mol.Pharmacol. 1994;45:469-74.
  • Clapper ML, Kuzmich S, Seestaller LM, Tew KD. Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure. Biochem Pharmacol. 1993;45:683-90.
  • Clapper ML, Hoffman SJ, Carp N, Watts P, Seestaller LM, Weese J, Tew KD. Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue. Carcinogenesis. 1991;12:1957-61.
  • O'Dwyer PJ, LaCreta F, Nash S, Tinsley PW, Schilder R, Clapper ML, Tew KD, Panting L, Litwin S, Comis RL, Ozols RF. Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. Cancer Res. 1991;51:6059-65.
  • Clapper ML, Hoffman SJ, Tew KD. Glutathione S-transferases in normal and malignant human colon tissue. Biochim Biophys Acta. 1991;1096:209-16.
  • Clapper ML, Hoffman SJ, Tew KD. Sensitization of human colon tumor xenografts to L-phenylalanine mustard using ethacrynic acid. J Cell Pharmacol. 1990;1:71-8.
  • Schisselbauer J, Cresciamanno M, D'Alessandro N, Clapper ML, Tapiero H, Tew KD. Glutathione, glutathione S-transferases and related redox enzymes in adriamycin resistant cell lines with a multidrug resistant phenotype. Cancer Communications. 1989;1:133-9.
  • Clapper ML, Tew KD. Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards. Biochem Pharmacol. 1989;38:1915-21.
  • Buller AL, Clapper ML, Tew KD. Glutathione S-transferases in nitrogen mustard-resistant and sensitive cell lines. Mol Pharmacol. 1987;31:575-8.
  • Tew KD, Clapper ML, Greenberg RE, Weese JL, Hoffman SJ, Smith TM. Glutathione S-transferases in human prostate. Biochem Biophys Acta. 1987;926:8-15.
  • Clapper ML, Klein NW. Identification of a teratogenic drug-protein complex in sera of phenytoin-treated monkeys. Epilepsia. 1986; 27:685-96.
  • Clapper ML, Clark ME, Klein NW, Kurtz PJ, Carlton BD, Chharba RS. Cardiovascular defects in rat embryos cultured on serum from rats chronically exposed to phenytoin. Teratogenesis, Carcinogenesis and Mutagenesis. 1986;6:151-61.
  • Chatot CL, Klein NW, Clapper ML, Resor SR, Singer WD, Russman BS, Holmes GL, Mattson RH, Cramer JA. Human serum teratogenicity studied by rat embryo culture: Epilepsy, anticonvulsant drugs, and nutrition. Epilepsia. 1984;25:205-16.
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Invited Reviews

  • Egleston BL, Meireles SI, Flieder DB, Clapper ML. Population-based trends in lung cancer incidence in women. Semin Oncol. 2009;36:506-15.
  • Clapper ML, Cooper HS, Chang W-CL. Dextran sulfate sodium-induced colitis-associated neoplasia – A promising model for the development of chemopreventive interventions. In: ANT Kong, editor. Molecular Targets, Biomarkers and Animal Models for Anti-Cancer Pharmacological Research: Potentials and Challenges from Chemoprevention to Chemotherapeutics. Acta Pharmacol Sin. 2007;28:1450-9.
  • Clapper ML, Coudry J, Chang W-CL. β catenin-mediated signaling: A molecular target for early chemopreventive intervention. Mutation Res. 2004;555:97-105.
  • Clapper ML, Chang W-CL, Meropol NJ. Chemoprevention of colorectal cancer. Curr Opin Oncol. 2001;13:307-13.
  • Clapper ML. Genetic polymorphism and cancer risk. Current Oncology Reports. 2000;2:251-6.
  • Clapper ML, Cooper HS, Murthy S. Prevention of colitis-associated colon cancer. Cancer Research Alert. 1999;1:43-5.
  • Clapper ML. Chemopreventive activity of oltipraz. Pharmacol Ther. 1998;78:17-27.
  • Wilkinson J, Clapper ML. Detoxication enzymes and chemoprevention. Proc Soc Exp Biol Med. 1997;216:192-200.
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Book Chapters

  • Wong Y-N, Chang W-C, Clapper M, Engstrom PF. Chemoprevention of colorectal cancer. In: LB Saltz, editor. Colorectal Cancer: Evidence-Based Chemotherapy Strategies. Totowa, NJ: Humana Press, Inc.; 2006; p. 33-49.
  • Engstrom PF, Clapper ML, Schnoll RA. Prevention of tobacco-related cancers. In: DW Kufe, RC Bast Jr., WN Hait, WK Hong, RE Pollock, RR Weichselbaum, JF Holland, E Frei III, editors. Cancer Medicine 7. Ontario, Canada: B. C. Dekker, Inc.; 2006; p. 354-62.
  • Engstrom PF, Clapper ML, Schnoll RA. Prevention of tobacco-related cancer. In: DW Kufe, RE Pollock, RR Weichselbaum, RC Bast Jr., TS Gansler, JE Holland, E Frei III, editors. Cancer Medicine, 6th Edition. Ontario, Canada: B. C. Dekker, Inc.; 2003; p. 383-96.
  • Engstrom PF, Clapper M, Schnoll RA, Orleans CT. Prevention of tobacco-related cancers. In: R Bast,Jr., D Kufe, R Pollock, R Weichselbaum, J Holland, E Frei III, editors. Cancer Medicine, 5th Edition. Ontario, Canada: B. C. Dekker, Inc.; 2000; p. 314-27.
  • London WT, Evans AA, Buetow K, Litwin S, McGlynn K, Zhou T, Clapper M, Ross E, Wild C, Shen F-M, Chen G-C, M’Boup S. Molecular and genetic epidemiology of hepatocellular carcinoma: studies in China and Senegal. In: K Kobayashi, RH Purcell, K Shimotohno, E Tabor, editors. Hepatitis C and its Involvement in the Development of Hepatocellular Carcinoma. Proc. Intl. Symp. of the Princess Takamatsu Cancer Research Fund, November 1994, Tokyo, Japan. Princeton: Princeton Scientific Publishing Co., Inc.; 1995; p. 51-60.
  • Tew KD, Schisselbauer JC, Clapper ML, Kuzmich S. Glutathione S-transferases and resistance to alkylating agents. In: JD Hayes, CB Pickett, TJ Mantle, editors. Glutathione S-Transferases and Drug Resistance. Philadelphia: Taylor and Francis; 1990; p. 309-17.
  • Clapper ML, O'Dwyer P, Tew KD. Sensitization of tumors to alkylating agents using inhibitors of glutathione S-transferases. In: JD Hayes, CB Pickett, TJ Mantle, editors. Glutathione S-Transferases and Drug Resistance. Philadelphia: Taylor and Francis; 1990; p. 451-9.
  • Tew KD, Clapper ML. Glutathione S-transferases in drug resistance. In: E Ghione, L Rausa, editors. Resistance to Antitumor Agents in Laboratory and Clinic. London: Harwood Academic Press; 1989; p. 95-103.
  • Clapper ML, Tew KD. Alkylating agent resistance. In: WL McGuire, RF Ozols, editors. Cancer Treatment and Research. Norwell, MA: Kluwer Academic Publishers; 1989; p. 125-50.
  • Tew KD, Clapper ML. Glutathione S-transferases and anticancer drug resistance. In: PV Woolley, KD Tew, editors. Mechanisms of Drug Resistance in Neoplastic Cells. New York: Academic Press; 1988; p. 141-59.
  • Clapper ML, Buller AL, Smith TM, Tew KD. Glutathione S-transferases in alkylating agent resistant cells. In: TJ Mantle, CB Pickett, JD Hayes, editors. Glutathione S-Transferases and Carcinogenesis. Philadelphia: Taylor and Francis; 1987; p. 213-24.
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