Faculty Summaries
Edna Cukierman, PhD
Edna Cukierman, PhD
Associate Professor
  • Co-leader Pancreas Research Interest Group
  • Chair Institutional Biosafety Committee
Office Phone: 215-214-4218
Lab Phone: 215-214-4219
Fax: 215-728-3616
Office: W428
Twitter: @ednacukierman
Desmoplastic Tumor Microenvironment
  • Mechanisms of fibrous desmoplastic activation and maintenance via integrin signaling and cytoskeletal dynamics.
  • Pancreatic, renal, mammary gland and other transformative alterations regulated by cancer- or tumor-associated fibroblasts (CAFs or TAFs) and their self-derived extracellular matrices (ECMs).
  • Clinical implications, translational aspects and means of microenvironment activation assessments; compartmental —tumoral and stromal— biomarker detection using multi-spectral and batch digital imaging analyses.
  • Decoupling of biochemical and biomechanical influences of desmoplasia by combinational 3D models of cell-derived ECMs and biomimetic material engineering.
  • Software for multi-spectra analysis (SMIA-CUKIE)
Description of research projects
Selected Publications
  1. Malik, R., Lelkes, P.I., Cukierman, E. Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends in Biotech, 33(4):230-236, 2015. PMCID: PMC4380578 [PubMed]
  2. Rybinski, B., Franco-Barraza, J., and Cukierman, E. The wound healing, chronic fibrosis and cancer progression triad, Physiological Genomics, 46(7):223-244, 2014. PMCID: PMC4035661 [PubMed]
  3. Håkanson M, Kobel S, Lutolf MP, Textor M, Cukierman E*, Charnley M*. Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses. PLoS ONE 2012;7(6): e40141. doi:10.1371/journal.pone.0040141 (*co-corresponding author). PLoS ONE
  4. Gupta V, Bassi DE, Simons JD, Devarajan K, Al-Saleem T, Uzzo RG, Cukierman E. Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma. PLoS One. 2011;6(6):e21494. Epub 2011 Jun 28. PubMed
  5. Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 2011 Jul 8;146(1):148-63. PubMed
  6. Lee HO, Mullins SR, Franco-Barraza J, Valianou M, Cukierman E*, Cheng JD*. FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer. 2011 Jun 13;11(1):245. (* co-corresponding author). PubMed
  7. Kwon Y, Cukierman E*, Godwin AK*. Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion. PLoS One. 2011 Apr 19;6(4):e18872. (* co-corresponding author). PubMed
  8. Castelló-Cros R, Khan DR, Simons J, Valianou M, Cukierman E. Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins. BMC Cancer. 2009 Mar 26;9:94. PubMed
  9. Serebriiskii I, Castello-Cros R, Lamb A, Golemis EA, and Cukierman E. Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biology. 2008;27:573-585. PubMed
  10. Quiros, RM., Valianou, M., Kwon, Y., Brown, KM., Godwin, AK., and Cukierman, E. Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner. Gynecologic Oncology., 110:99-109, 2008. PMCID: PMC2612536 [PubMed]
  11. Yamada, K. M., Cukierman, E. Modeling tissue morphogenesis and cancer in 3D. Cell. 130:601-610, 2007. (Accepted prior to April 2007). [PubMed]
  12. Amatangelo MD, Bassi DE, Klein-Szanto AJ, Cukierman E. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol. 2005;167(2):475-88. PubMed
  13. Cukierman E, Pankov R, Stevens DR, and Yamada KM. Taking cell-matrix adhesions to the third dimension. Science. 2001;294:1708-1712. PubMed
All publications