Faculty Summaries
Edna Cukierman, PhD
Edna Cukierman, PhD
Associate Professor
Office Phone: 215-214-4218
Lab Phone: 215-214-4219
Fax: 215-728-3616
Office: W428
Twitter: @ednacukierman

Original Articles

  • Rybinski B, Franco-Barraza J and Cukierman E. The wound healing, chronic fibrosis and cancer progression triad. Physiological Genomics, 2014; in press.
  • HÃ¥kanson M, Cukierman E*, and Charnley M*. Miniaturized pre-clinical cancer models as research and diagnostic tools. Advanced Drug Delivery Reviews, 2014; in press. doi: 10.1016/j.addr.2013.11.010 (* co-corresponding author). Available online ahead of publication
  • Campbell, C.B., Cukierman, E., and Artym, V.V. 3D extracellular matrix from sectioned human tissues. Curr Protoc Cell Biol 2013; in press.
  • Wong, G.S., Lee, J.-S., Park, Y.-Y., Klein-Szanto, A.J., Waldron, T.J., Cukierman, E., Herlyn, M., Gimotty, P., Nakagawa, H., and K.Rustgi, A. Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment. Oncogenesis, 2013;5(2):e59 doi: 10.1038/oncsis.2013.17. PubMed
  • H�kanson M, Kobel S, Lutolf MP, Textor M, Cukierman E*, Charnley M*. Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses. PLoS ONE 2012;7(6): e40141. doi:10.1371/journal.pone.0040141 (*co-corresponding author). PLoS ONE
  • Cukierman E, Bassi D. The mesenchymal tumor microenvironment: A drug resistant niche. Cell Adh Migr. 2012 May 1;6(3). PubMed
  • Valdivia-Silva, J.; Franco-Barraza, J.; Cukierman, E., Garcia-Zepeda, E., Novel Insights into the Role of Inflammation in Promoting Breast Cancer Development. In Breast Cancer - Focusing Tumor Microenvironment, Stem cells and Metastasis, Gunduz, M.; Gunduz, E., Eds. InTech: 2011; Vol. Book 4, pp 129-164. Link to Article
  • Gupta V, Bassi DE, Simons JD, Devarajan K, Al-Saleem T, Uzzo RG, Cukierman E. Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma. PLoS One. 2011;6(6):e21494. Epub 2011 Jun 28. PubMed
  • Goetz JG, Minguet S, Navarro-L�rida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ib��ez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, S�nchez-Mateos P, Cukierman E, Del Pozo MA. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 2011 Jul 8;146(1):148-63. PubMed
  • Lee HO, Mullins SR, Franco-Barraza J, Valianou M, Cukierman E*, Cheng JD*. FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer. 2011 Jun 13;11(1):245. (* co-corresponding author). PubMed
  • Kwon Y, Cukierman E*, Godwin AK*. Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion. PLoS One. 2011 Apr 19;6(4):e18872. (* co-corresponding author). PubMed
  • Shatalova EG, Klein-Szanto AJ, Devarajan K, Cukierman E, Clapper ML. Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Jan;4(1):107-15. PubMed
  • Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. Neoplasia. 2010 Jul;12(7):516-26. PubMed
  • Cukierman E, Bassi DE. Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol. 2010 May 7. PubMed
  • Goicoechea SM, Bednarski B, Stack C, Cowan DW, Volmar K, Thorne L, Cukierman E, Rustgi AK, Brentnall T, Hwang RF, McCulloch CA, Yeh JJ, Bentrem DJ, Hochwald SN, Hingorani SR, Kim HJ, Otey CA. Isoform-specific upregulation of palladin in human and murine pancreas tumors. PLoS One. 2010 Apr 26;5(4):e10347. PubMed
  • Cukierman E, Khan DR. The benefits and challenges associated with the use of drug delivery systems in cancer therapy. Biochem Pharmacol. 2010 Sep 1;80(5):762-70. Epub 2010 Apr 22. PubMed
  • Castell�-Cros R, Khan DR, Simons J, Valianou M, Cukierman E. Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins. BMC Cancer. 2009 Mar 26;9:94.
  • Castell�-Cros R, Cukierman E. Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices. Methods Mol Biol. 2009;522:275-305.
  • Quiros RM, Valianou M, Kwon Y, Brown KM, Godwin AK, Cukierman E. Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner. Gynecol Oncol. 2008 Jul;110(1):99-109. Epub 2008 May 2.
  • Serebriiskii I, Castell�-Cros R, Lamb A, Golemis EA, Cukierman E. Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol. 2008 Jul;27(6):573-85. Epub 2008 Mar 6.
  • Beacham DA, Amatangelo MD, Cukierman E. Preparation of extracellular matrices produced by cultured and primary fibroblasts. Curr Protoc Cell Biol. 2007 Jan;Chapter 10:Unit 10.9.
  • Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev. 2007 Nov1;21(21):2788-803.
  • Damianova R, Stefanova N, Cukierman E, Momchilova A, Pankov R. Three-dimensional matrix induces sustained activation of ERK1/2 via Src/Ras/Raf signaling pathway. Cell Biol Int. 2008 Feb;32(2):229-34. Epub 2007 Sep 7.
  • Yamada KM, Cukierman E. Modeling tissue morphogenesis and cancer in 3D. Cell. 2007 Aug 24;130(4):601-10. Review.
  • Cukierman E. Tumour development due to stroma permissiveness. J Biosci. 2005 Dec;30(5):551-2.
  • Pankov R, Endo Y, Even-Ram S, Araki M, Clark K, Cukierman E, Matsumoto K, Yamada KM. A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol. 2005 Aug 29;170(5):793-802.
  • Bassi DE, Lopez De Cicco R, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Cancer Res. 2005 Aug 15;65(16):7310-9.
  • Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res. 2005 Aug 1;11(15):5347-55.
  • Amatangelo MD, Bassi DE, Klein-Szanto AJ, Cukierman E. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol. 2005 Aug;167(2):475-88.
  • Beacham DA, Cukierman E. Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression. Semin Cancer Biol. 2005 Oct;15(5):329-41. Review.
  • Cukierman E. A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression. J Mammary Gland Biol Neoplasia. 2004 Oct;9(4):311-24. Review.
  • Cukierman E. Cell migration analyses within fibroblast-derived 3-D matrices. Methods Mol Biol. 2005;294:79-93.
  • Einarson MB, Cukierman E, Compton DA, Golemis EA. Human enhancer ofinvasion-cluster, a coiled-coil protein required for passage through mitosis. Mol Cell Biol. 2004 May;24(9):3957-71.
  • Yamada KM, Pankov R, Cukierman E. Dimensions and dynamics in integrin function. Braz J Med Biol Res. 2003 Aug;36(8):959-66. Epub 2003 Jul 23. Review.
  • Zajaczkowski MB, Cukierman E, Galbraith CG, Yamada KM. Cell-matrix adhesions on poly(vinyl alcohol) hydrogels. Tissue Eng. 2003 Jun;9(3):525-33.
  • Katz BZ, Romer L, Miyamoto S, Volberg T, Matsumoto K, Cukierman E, Geiger B, Yamada KM. Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. J Biol Chem. 2003 Aug 1;278(31):29115-20. Epub 2003 May 16.
  • Engelholm LH, List K, Netzel-Arnett S, Cukierman E, Mitola DJ, Aaronson H, Kj�ller L, Larsen JK, Yamada KM, Strickland DK, Holmbeck K, Dan� K, Birkedal-Hansen H, Behrendt N, Bugge TH. uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol. 2003 Mar 31;160(7):1009-15.
  • Pankov R, Cukierman E, Clark K, Matsumoto K, Hahn C, Poulin B, Yamada KM. Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem. 2003 May 16;278(20):18671-81. Epub 2003 Mar 11.
  • Aframian DJ, Tran SD, Cukierman E, Yamada KM, Baum BJ. Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland. Tissue Eng. 2002 Oct;8(5):871-8.
  • Cukierman E, Pankov R, Yamada KM. Cell interactions with three-dimensional matrices. Curr Opin Cell Biol. 2002 Oct;14(5):633-9. Review.
  • Aframian DJ, Redman RS, Yamano S, Nikolovski J, Cukierman E, Yamada KM, Kriete MF, Swaim WD, Mooney DJ, Baum BJ. Tissue compatibility of two biodegradable tubular scaffolds implanted adjacent to skin or buccal mucosa in mice. Tissue Eng. 2002 Aug;8(4):649-59.
  • Huber I, Cukierman E, Rotman M, Cassel D. ARF GTPase-activating protein 1. Methods Mol Biol. 2002;189:199-206.
  • Cukierman E, Pankov R, Stevens DR, Yamada KM. Taking cell-matrix adhesions to the third dimension. Science. 2001 Nov 23;294(5547):1708-12.
  • Aframian DJ, Zheng C, Goldsmith CM, Nikolovski J, Cukierman E, Yamada KM, Mooney DJ, Birkedal-Hansen H, Baum BJ. Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line. Tissue Eng. 2001 Aug;7(4):405-13.
  • Huber I, Rotman M, Pick E, Makler V, Rothem L, Cukierman E, Cassel D. Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1. Methods Enzymol. 2001;329:307-16.
  • Aframian DJ, Cukierman E, Nikolovski J, Mooney DJ, Yamada KM, Baum BJ. The growth and morphological behavior of salivary epithelial cells on matrix protein-coated biodegradable substrata. Tissue Eng. 2000 Jun;6(3):209-16.
  • Pankov R, Cukierman E, Katz BZ, Matsumoto K, Lin DC, Lin S, Hahn C, Yamada KM. Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol. 2000 Mar 6;148(5):1075-90.
  • Baum BJ, Wang S, Cukierman E, Delporte C, Kagami H, Marmary Y, Fox PC, Mooney DJ, Yamada KM. Re-engineering the functions of a terminally differentiated epithelial cell in vivo. Ann N Y Acad Sci. 1999 Jun 18;875:294-300. Review.
  • Wang S, Cukierman E, Swaim WD, Yamada KM, Baum BJ. Extracellular matrix protein-induced changes in human salivary epithelial cell organization and proliferation on a model biological substratum. Biomaterials. 1999 Jun;20(11):1043-9.
  • Huber I, Cukierman E, Rotman M, Aoe T, Hsu VW, Cassel D. Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein. J Biol Chem. 1998 Sep 18;273(38):24786-91.
  • Aoe T, Cukierman E, Lee A, Cassel D, Peters PJ, Hsu VW. The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. EMBO J. 1997 Dec 15;16(24):7305-16.
  • Poon PP, Wang X, Rotman M, Huber I, Cukierman E, Cassel D, Singer RA, Johnston GC. Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10074-7.
  • Cukierman E, Huber I, Rotman M, Cassel D. The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science. 1995 Dec 22;270(5244):1999-2002.
  • Makler V, Cukierman E, Rotman M, Admon A, Cassel D. ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization. J Biol Chem. 1995 Mar 10;270(10):5232-7.
  • Cassel D, Shoubi S, Glusman G, Cukierman E, Rotman M, Zilberstein D. Leishmania donovani: characterization of a 38-kDa membrane protein that cross-reacts with the mammalian G-protein transducin. Exp Parasitol. 1991 May;72(4):411-7.
  • For a complete list of Dr. Cukierman's publications, click here.