Faculty Summaries
Greg H. Enders, MD, PhD
Greg H. Enders, MD, PhD
Associate Professor
Office Phone: 215-214-3956
Fax: 215-728-4333
Office: W225
Regulation of the Mammalian Cell Division Cycle and Gastrointestinal Tumorigenesis

Our program focuses on a key family of enzymes, termed cyclin dependent kinases (Cdks), that drive successive steps of cell duplication. Activation of these enzymes is needed for every cell to divide. Deregulation of Cdks contributes to cancer development, because it allows cells to duplicate uncontrollably. Conversely, inhibition of Cdks suppresses cancer by preventing cells from duplicating. Our research spans the spectrum from clinical to basic research, using patient tissue samples, mouse models, and biochemical studies. Themes include the effects of Cdks on stem cells (which duplicate to replace lost cells), and on cellular senescence (the process that causes older cells to stop duplicating). A goal is to identify how Cdk function and regulation in tumor cells differs from that in normal cells and to take advantage of these differences in cancer prevention and therapy.

Description of research projects
Selected Publications
  1. Li C, Andrake M, Dunbrack R, Enders GH. A bi-functional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. Molecular and Cellular Biology. 2010;30:116-30.
  2. Boquoi A, Jover R, Chen T, Pennings M, Enders G. Transgenic expression of VEGF in intestinal epithelium drives mesenchymal cell interactions and epithelial neoplasia. Gastroenterology. 2009 Feb;136(2):596-606.e4. PubMed
  3. Gibson SL, Dai CY, Lee HW, DePinho RA, Gee MS, Lee WM, Furth EE, Brensinger C, Enders GH. Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Research 2003 Feb 15;63(4):742-6. PubMed
  4. Hu B, Mitra J, Van den Heuvel S, Enders GH. S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells. Molecular & Cellular Biology 2001 Apr;21(8):2755-66. PubMed
  5. Dai CY, Enders GH.: p16 INK4a can initiate an autonomous senescence program. Oncogene 2000 Mar 23;19(13):1613-22. PubMed
All publications