Faculty Summaries
Greg H. Enders, MD, PhD
Greg H. Enders, MD, PhD
Associate Professor
Office Phone: 215-214-3956
Fax: 215-728-4333
Office: W225

Original Articles

  • Kennedy AL, Morton JP, Manoharan I, Nelson DM, Pawlikowski J, Jamieson NB, McBryan T, Doyle B, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD. Activation of the PIK3CA/AKT pathway suppresses senescense induced by an activated RAS oncogene to promote tumorigenesis. Molecular Cell. 2011, 42:36-49.
  • Enders GH. Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry. Cell Division. 2010;5:12.
  • von Holzen Q, Chen T, Boquoi A, Richter J, Falk GW, Klein-Szanto A, Cooper H, Litwin S, Weinberg D, Enders GH. Evidence for DNA damage checkpoint activation in Barrett’s esophagus. Translational Oncology. 2010;3:33-42.
  • Li C, Andrake M, Dunbrack R, Enders GH. A bi-functional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. Molecular and Cellular Biology. 2010;30:116-30.
  • Kennedy AL, McBryant T, Enders GH, Johnson B, Zhang R, Adams PD. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. BMC Cell Division 2010;5:16, in process
  • Boquoi A, Jover R, Chen T, Pennings M, Enders GH. Transgenic expression of VEGF in intestinal epithelium drives mesenchymal cell interactions and epithelial neoplasia. Gastroenterology. 2009;136:596-606.
  • Pay� A, Alenda C, P�rez-Carbonell L, Rojas E, Castells A, Llor X, Andreu M, Soto J-L, Guill�n C, Castillejo A, Barber� VM, Carrato A, Koh JK, Enders GH, Benlloch S, Jover R. Utility of p16 immunmohistochemistry for identification of the Lynch syndrome. Clinical Cancer Research. 2009;15:3156-62.
  • Boquoi A, Chen T, Enders, GH. Chemoprevention of colon tumorigenesis in a mouse model by the CDK inhibitor SNS-032. Cancer Prevention Research 2009;2:800-6.
  • Enders GH. Wnt therapy for bone loss: golden goose or Trojan horse? Journal of Clinical Investigation 2009;119(4):758-60.
  • Adams PD, Enders GH. Wnt signaling and senescence: a tug of war in early neoplasia? Cancer Biol Ther. Nov 2008;7:1706-11.
  • Boquoi A, Enders GH. Adenomatous polyposis coli mutations in colon cancer - slipping off the brake and onto the gas pedal. Cancer Biol Ther. 2008;7(4).
  • Enders GH. Expanded roles for Chk1 in genome maintenance. J Biol Chem. 2008;283:17749-52.
  • Dews M, Homayouni A, Yu D et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet. 2006;38(9):1060-5.
  • Enders GH, Maude SL. Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability. Gene. 2006;371(1):1-6.
  • Furth EE, Gustafson KS, Dai CY et al. Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis. Neoplasia. 2006;8(6):429-36.
  • Gibson SL, Boquoi A, Chen T et al. p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors. Cancer Biol Ther. 2005;4(12):1389-94.
  • Gibson SL, Dai CY, Lee H-W et al. Inhibition of colon tumor progression by the Ink4a/Arf locus. Cancer Research. 2003;63(4):742-6.
  • Enders GH. Cyclins in breast cancer: too much of a good thing. Breast Cancer Res. 2002;4(4):145-7.
  • Dai CY, Furth EE, Mick R et al. p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. Gastroenterology. 2000 Oct;119(4):929-42.
  • Dai CY, Enders GH. p16 INK4a can initiate an autonomous senescence program. Oncogene. 2000 Mar 23;19(13):1613-22.

Book Chapters

  • Enders GH. (Editor). Cell Cycle De-Regulation in Cancer. Springer Science and Business Media, 2010
  • Enders G. The INK4a/ARF locus and human cancer. In: El-Deiry W, editor. Tumor supressor genes: methods and protocols. Vol. 222, Methods in molecular medicine. Totowa, NJ: The Humana Press, Inc.;2002. p.197-209.