Jenny P Glusker, DPhil, DSc
Office Phone: 215-728-2220
The interactions between molecules in biological systems, leading to biochemical reactions or complex formation, are analyzed in our laboratory by three-dimensional X-ray and neutron diffraction methods. We investigate the structures of chemical carcinogens, their activated metabolites and their adducts with portions of DNA in order to assess those features that impart carcinogenic potential to a polycyclic aromatic hydrocarbon. We also study metal ion binding, and the ability of ligands to be polarized by them. Metal-binding motifs in macromolecular crystal structures are analyzed for structure-function activities. The enzyme structure currently under study by neutron and high-resolution X-ray is D-xylose isomerase.