Faculty Summaries
Elizabeth Hopper-Borge, PhD
Elizabeth Hopper-Borge, PhD
Assistant Professor
Office Phone: 215-214-1505
Lab Phone: 215-214-3757
Fax: 215-728-3616
Office: W463
Drug Resistance Mechanisms

Cellular resistance to chemotherapeutic agents is a major obstacle to cancer treatment. ATP-binding cassette (ABC) transporters are involved in resistance by virtue of their ability to extrude drugs from the cell. Multidrug Resistance Proteins (MRPs) are drug efflux pumps that reside in the C family of ABC transporters - one of the largest families of ABC transporters. Similar to other family members, MRP7 is able to transport amphipathic anions, and MRP7 confers resistance to a wide variety of anticancer agents including taxanes, vinca alkaloids and nucleoside- based agents. Our laboratory is using a variety of models, biochemical, cellular and In vivo to further examine the role of MRP7 in cellular resistance.

Description of research projects
Selected Publications

Fox Chase Programs

  1. Pushpakom SP, Liptrott NJ, Rodríguez-Nóvoa S, Labarga P, Soriano V, Albalater M, Hopper-Borge E, Bonora S, Di Perri G, Back DJ, Khoo S, Pirmohamed M, Owen A. Genetic variants of ABCC10, a novel tenofovir. J Infect Dis. 2011 Jul;204(1):145-53. PubMed
  2. Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs JD, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen ZS, Klein-Szanto AJ, Belinsky MG, Kruh GD. Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice. Cancer Res. 2011 May 15;71(10):3649-3657. PubMed
  3. Hopper-Borge E, Nasto RN, Ratushny V, Weiner LM, Golemis EA, Astsaturov I. Mechanisms of tumor resistance to EGFR-targeted therapies. Exp Opin Ther Targets. 2009;13(3):339-362. PubMed
  4. Zhou Y, Hopper-Borge E, Shi Z, Shen T, Furukawa T, Akiyama S, Peng XX, Huang XC, Ashby C, Kruh GD, Chen ZS. Cepharanthine is a potent reversal agent for MRP7-mediated multidrug resistance. Biochem Pharmacol. 2009;77:993-1001. PubMed
  5. Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009;69:178-184. PubMed
  6. Risinger AL, Jackson EM, Polin LA, Helms GL, LeBoeuf DA, Joe PA, Hopper-Borge E, Luduena RF, Kruh GD, Mooberry SL. The taccolonides: microtubule stabilizers that circumvent clinically relevant taxane resistant mechanisms. Cancer Res. 2008;68:8881-88. PubMed
  7. Hopper-Borge E, Chen Z-S, Shchaveleva I, Belinsky MG, Kruh GD. Analysis of the drug resistance profile of MRP7 (ABCC10): resistance to docetaxel. Cancer Res. 2004;64:4927-30. PubMed
  8. Hopper E, Belinsky M, Zeng H, Tosolini A, Testa J, Kruh G. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. Cancer Letters. 2001;162:181-191. PubMed
All publications