Faculty Summaries
Richard A. Katz
Richard A. Katz, PhD
Research Professor
  • Adjunct Professor,
    Fels Institute for Cancer Research and Molecular Biology,
    Temple University School of Medicine, Philadelphia, PA
Lab Phone: 215-728-3668
Fax: 215-728-2778
Office: R422


  • Peretz, Y., Wu, H., Patel, S., *Katz R.A. Identification of inhibitor of differentiation 4 (ID4) as a mediator of melanoma cell plasticity. Manuscript in preparation.
  • Poleshko, A., Kossenkov, A., Einarson, M.B., Shalginskikh, N., Skalka, A.M., *Katz, R.A. Genome-wide siRNA screen identifies novel networks of human epigenetic regulators. Manuscript in preparation.
  • Poleshko, A., Mansfield, K., Burlingame, C., Andrake, M.D., Shah, N.R. *Katz, R.A. The human protein PRR14 tethers heterochromatin to the nuclear lamina during interphase and mitotic exit. Cell Reports, in press, 2013.
  • Shalginskikh, N., Poleshko, A., Skalka, A.M., *Katz, R.A. Retroviral DNA methylation and epigenetic repression are mediated by the antiviral host protein Daxx. J. Virol. 87:2137-2150, 2013. (SPOTLIGHT Article of Significant Interest Selected by the Editors)
  • Poleshko, A., Shalginskikh N., *Katz, R.A. Identification of epigenetic silencing factors by siRNA screening. Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press, K Appasani, Editor., 2012.
  • Katz RA, Merkel G, Andrake MD, Roder H, Skalka AM. Retroviral integrases promote fraying of viral DNA ends. J Biol Chem. 286:25710-8, 2011
  • Poleshko A, Einarson MB, Shalginskikh N, Zhang R, Adams PD, Skalka AM, Katz RA. Identification of a functional network of human epigenetic silencing factors. J Biol Chem. 2010 Jan 1;285(1):422-33.
  • Frescas D, Guardavaccaro D, Kuchay SM, Kato H, Poleshko A, Basrur V, Elenitoba-Johnson KS, Katz RA, Pagano M. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle. 2008 Nov 15;7(22):3539-47.
  • Katz RA, Daniel R, Skalka AM. Host factors that affect provirus stability and silencing. In: Wand B, Meamati, N., editor. HIV-1 Integrase: Mechanisms Of Action And Inhibitor Design. United Kingdom: John Wiley & Sons, Inc., 2008.
  • Poleshko A, Palagin I, Zhang R, Boimel P, Castagna C, Adams PD, Skalka AM, Katz RA. Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. J Virol. 2008 Mar;82(5):2313-23.
  • Katz RA, Jack-Scott E, Narezkina A, Palagin I, Boimel P, Kulkosky J, Nicolas E, Greger JG, Skalka AM. High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. J Virol. 2007 Mar;81(6):2592-604.
  • Leis J, Katz RA. New insights into the mechanism of HIV-1DNA integration: a role for the host factor LEDGF/p75. Cell Sci Rev. 2006;2:25.
  • Skalka AM, Katz RA. Retroviral DNA integration and the DNA damage response. Cell Death Differ. 2005 Aug;12 Suppl 1:971-8.
  • Greger JG, Katz RA, Ishov AM, Maul GG, Skalka AM. The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription. J Virol. 2005 Apr;79(8):4610-8.
  • Katz RA, Greger JG, Skalka AM. Effects of cell cycle status on early events in retroviral replication. J Cell Biochem. 2005 Apr 1;94(5):880-9.
  • Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM. Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair. J Biol Chem. 2004 Oct 29;279(44):45810-4.
  • Narezkina A, Taganov KD, Litwin S, Stoyanova R, Hayashi J, Seeger C, Skalka AM, Katz RA. Genome-wide analyses of avian sarcoma virus integration sites. J Virol. 2004 Nov;78(21):11656-116563.
  • Daniel R, Greger JG, Katz RA, Taganov KD, Wu X, Kappes JC, Skalka AM. Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway. J Virol. 2004 Aug;78(16):8573-81.
  • Taganov KD, Cuesta I, Daniel R, Cirillo LA, Katz RA, Zaret KS, Skalka AM. Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro. J Virol. 2004 Jun;78(11):5848-55.
  • Greger JG, Katz RA, Taganov K, Rall GF, Skalka AM. Transduction of terminally differentiated neurons by avian sarcoma virus. J Virol. 2004 May;78(9):4902-6.
  • Katz RA, Greger JG, Boimel P, Skalka AM. Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells. J Virol. 2003 Dec;77(24):13412-7.
  • Daniel R, Kao G, Taganov K, Greger JG, Favorova O, Merkel G, Yen TJ, Katz RA, Skalka AM. Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proc Natl Acad Sci USA. 2003 Apr 15;100(8):4778-83.
  • Katz RA. Retroviruses. In: Kazazian H, Klein G, Moser HW, editors. Wiley Encyclopedia of Molecular Medicine: Wiley & Sons, Inc.; 2002.
  • Katz RA, Greger JG, Darby K, Boimel P, Rall GF, Skalka AM. Transduction of interphase cells by avian sarcoma virus. J Virol. 2002 Jun;76(11):5422-34.
  • Katz RA, DiCandeloro P, Kukolj G, Skalka AM. Role of DNA end distortion in catalysis by avian sarcoma virus integrase. J Biol Chem. 2001 Sep 7;276(36):34213-20.
  • Taganov K, Daniel R, Katz RA, Favorova O, Skalka AM. Characterization of retrovirus-host DNA junctions in cells deficient in nonhomologous-end joining. J Virol. 2001 Oct;75(19):9549-52.
  • Daniel R, Litwin S, Katz RA, Skalka AM. Computational analysis of retrovirus-induced scid cell death. J Virol. 2001 Apr;75(7):3121-8.
  • Daniel R, Katz RA, Merkel G, Hittle JC, Yen TJ, Skalka AM. Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses. Mol Cell Biol. 2001 Feb;21(4):1164-72.
  • Daniel R, Katz RA, Skalka AM. A role for DNA-PK in retroviral DNA integration. Science. 1999 Apr 23;284(5414):644-7.
  • Katzman M, Katz RA. Substrate recognition by retroviral integrases. Adv Virus Res. 1999;52:371-95.
  • Lubkowski J, Yang F, Alexandratos J, Merkel G, Katz RA, Gravuer K, Skalka AM, Wlodawer A. Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase. J Biol Chem. 1998 Dec 4;273(49):32685-9.
  • Kukolj G, Katz RA, Skalka AM. Characterization of the nuclear localization signal in the avian sarcoma virus integrase. Gene. 1998 Nov 26;223(1-2):157-63.
  • Bouck J, Litwin S, Skalka AM, Katz RA. In vivo selection for intronic splicing signals from a randomized pool. Nucleic Acids Res. 1998 Oct 1;26(19):4516-23.
  • Katz RA, Gravuer K, Skalka AM. A preferred target DNA structure for retroviral integrase in vitro. J Biol Chem. 1998 Sep 11;273(37):24190-5.
  • Bouck J, Fu XD, Skalka AM, Katz RA. Role of the constitutive splicing factors U2AF65 and SAP49 in suboptimal RNA splicing of novel retroviral mutants. J Biol Chem. 1998 Jun 12;273(24):15169-76.
  • Alexandratos J, Bujacz G, Jaskólski M, Wlodawer A, Merkel G, Katz J, Skalka AM. Crystal structure of avian sarcoma viirus integrase with bound essential cations. Techniques in Protein Chemistry VIII: Academic Press; 1997. p. 417-25.
  • Bujacz G, Alexandratos J, Wlodawer A, Merkel G, Andrake M, Katz RA, Skalka AM. Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J Biol Chem. 1997 Jul 18;272(29):18161-8.
  • Bujacz G, Jaskólski M, Alexandratos J, Wlodawer A, Katz RA, Skalka AM. Crystal structure of the catalytic domain of avian virus integrase. In: Marshak DR, editor. Techniques in Protein Chemistry VII. New York: Academic Press; 1996.
  • Bujacz G, Jaskólski M, Alexandratos J, Wlodawer A, Merkel G, Katz RA, Skalka AM. The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations. Structure. 1996 Jan 15;4(1):89-96.
  • Katz RA, Merkel G, Skalka AM. Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles. Virology. 1996 Mar 1;217(1):178-90.
  • Bujacz G, Jaskólski M, Alexandratos J, Wlodawer A, Merkel G, Katz RA, Skalka AM. High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J Mol Biol. 1995 Oct 20;253(2):333-46.
  • Bouck J, Fu XD, Skalka AM, Katz RA. Genetic selection for balanced retroviral splicing: novel regulation involving the second step can be mediated by transitions in the polypyrimidine tract. Mol Cell Biol. 1995 May;15(5):2663-71.
  • Kulkosky J, Katz RA, Merkel G, Skalka AM. Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase. Virology. 1995 Jan 10;206(1):448-56.
  • Katz RA, Skalka AM. The retroviral enzymes. Annu Rev Biochem. 1994;63:133-73.
  • Katz RA, Mack JP, Merkel G, Kulkosky J, Ge Z, Leis J, Skalka AM. Requirement for a conserved serine in both processing and joining activities of retroviral integrase. Proc Natl Acad Sci USA. 1992 Aug 1;89(15):6741-5.
  • Kulkosky J, Jones KS, Katz RA, Mack JP, Skalka AM. Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol Cell Biol. 1992 May;12(5):2331-8.
  • Fu XD, Katz RA, Skalka AM, Maniatis T. The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA. Genes Dev. 1991 Feb;5(2):211-20.
  • Khan E, Mack JP, Katz RA, Kulkosky J, Skalka AM. Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res. 1991 Feb 25;19(4):851-60.
  • Katz RA, Merkel G, Kulkosky J, Leis J, Skalka AM. The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell. 1990 Oct 5;63(1):87-95.
  • Kulkosky J, Katz RA, Skalka AM. Terminal nucleotides of the preintegrative linear form of HIV-1 DNA deduced from the sequence of circular DNA junctions. J Acquir Immune Defic Syndr. 1990;3(9):852-8.
  • Katz RA, Skalka AM. Generation of diversity in retroviruses. Annu Rev Genet. 1990;24:409-45.
  • Katz RA, Skalka AM. Control of retroviral RNA splicing through maintenance of suboptimal processing signals. Mol Cell Biol. 1990 Feb;10(2):696-704.
  • Skalka AM, Bizub D, Kotler M, Katz RA, Leis J, Cameron C, Danho W, Wlodawer A, Weber IT, Miller M, Jaskólski M, Rao M, editors. Biochemical and physical studies of retroviral protease. Proceedings for the First Roche Symposium, Clinical Pharmacology; 1989; Zuckschwerdt Verland Munich.
  • Leis J, Bizub D, Weber IT, Cameron C, Katz RA, Wlodawer A, Skalka AM. Structure-function analysis of the retroviral aspartic proteinase In: Kräusslich H, Oroszlan S, Wimmer E, editors. Current Communications in Molecular Biology: Viral Proteinases as Targets for Chemotherapy. Cold Spring Harbor, NY: Cold Spring Harbor Press; 1989. p. 235-43.
  • Katz RA, Jentoft JE. What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins? Bioessays. 1989 Dec;11(6):176-81.
  • Katzman M, Katz RA, Skalka AM, Leis J. The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol. 1989 Dec;63(12):5319-27.
  • Kotler M, Danho W, Katz RA, Leis J, Skalka AM. Avian retroviral protease and cellular aspartic proteases are distinguished by activities on peptide substrates. J Biol Chem. 1989 Feb 25;264(6):3428-35.
  • Kotler M, Katz RA, Skalka AM. Activity of avian retroviral protease expressed in Escherichia coli. J Virol. 1988 Aug;62(8):2696-700.
  • Katz RA, Kotler M, Skalka AM. cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: implication for mechanisms of control. J Virol. 1988 Aug;62(8):2686-95.
  • Kotler M, Katz RA, Danho W, Leis J, Skalka AM. Synthetic peptides as substrates and inhibitors of a retroviral protease. Proc Natl Acad Sci USA. 1988 Jun;85(12):4185-9.
  • Fu XD, Katz RA, Skalka AM, Leis J. Site-directed mutagenesis of the avian retrovirus nucleocapsid protein, pp 12. Mutation which affects RNA binding in vitro blocks viral replication. J Biol Chem. 1988 Feb 15;263(5):2140-5.
  • Katz RA, Skalka AM. A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. J Virol. 1988 Feb;62(2):528-33.
  • Cobrinik D, Katz R, Terry R, Skalka AM, Leis J. Avian sarcoma and leukosis virus pol-endonuclease recognition of the tandem long terminal repeat junction: minimum site required for cleavage is also required for viral growth. J Virol. 1987 Jun;61(6):1999-2008.
  • Katz RA, Fu XD, Skalka AM, Leis J. Avian retrovirus nucleocapsid protein, pp12, produced in Escherichia coli has biochemical properties identical to unphosphorylated viral protein. Gene. 1986;50(1-3):361-9.
  • Katz RA, Terry RW, Skalka AM. A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging. J Virol. 1986 Jul;59(1):163-7.
  • Katz RA, Cullen BR, Malavarca R, Skalka AM. Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. Mol Cell Biol. 1986 Feb;6(2):372-9.
  • Cullen BR, Katz RA, Ju G. Expression of transfected DNA in avian cells can be enhanced in trans by retroviral infection. Mol Cell Biol. 1985 Jul;5(7):1804-7.
  • Bizub D, Katz RA, Skalka AM. Nucleotide sequence of noncoding regions in Rous-associated virus-2: comparisons delineate conserved regions important in replication and oncogenesis. J Virol. 1984 Feb;49(2):557-65.
  • Mitsialis SA, Katz RA, Svoboda J, Guntaka RV. Studies on the structure and organization of avian sarcoma proviruses in the rat XC cell line. J Gen Virol. 1983 Sep;64 (Pt 9):1885-93.
  • Katz RA, Erlanger BF, Guntaka RV. Evidence for extensive methylation of ribosomal RNA genes in a rat XC cell line. Biochim Biophys Acta. 1983 Apr 15;739(3):258-64.
  • Katz RA, Mitsialis SA, Guntaka RV. Studies on the methylation of avian sarcoma proviruses in permissive and non-permissive cells. J Gen Virol. 1983 Feb;64 (Pt 2):429-35.
  • Katz RA, Omer CA, Weis JH, Mitsialis SA, Faras AJ, Guntaka RV. Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions. J Virol. 1982 Apr;42(1):346-51.
  • Miller OJ, Tantravahi U, Katz RA, Erlanger BF, Guntaka RV, editors. Amplification of mammalian ribosomal RNA genes and their regulation by methylation. "Genes, Chromosomes and Neoplasia". 33rd Annual Symposium on Fundamental Cancer Research; 1981; The University of Texas System Cancer Center: Raven Press, New York, NY.
  • Guntaka RV, Rao PY, Mitsialis SA, Katz R. Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells. J Virol. 1980 May;34(2):569-72.
  • Guntaka RV, Rao PY, Katz RA, Mitsialis SA. Binding of Escherichia coli RNA polymerase to a specific site located near the 3'-end of the avaian sarcoma virus genome. Biochim Biophys Acta. 1980 May 30;607(3):457-69.
  • Guntaka RV, Katz RA, Weiner AJ, Widman MM. Effect of 5-methylcytidine on virus production in avian sarcoma virus-infected chicken embryo cells. J Virol. 1979 Feb;29(2):475-82.
  • Katz RA, Maniatis GM, Guntaka RV. Translation of avian sarcoma virus RNA in Xenopus laevis oocytes. Biochem Biophys Res Commun. 1979 Jan 30;86(2):447-53.