Faculty Summaries
Vladimir Kolenko
Vladimir Kolenko, MD, PhD
Associate Professor
  • Adjunct Professor, Temple University
Vladimir.Kolenko@fccc.edu
Office Phone: 215-728-5620
Fax: 215-728-4333
Office: W246

Publications

  • Golovine, K., Makhov, P., Teper, E., Kutikov, A., Canter, D., Uzzo, R.G., Kolenko, V.M.  Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate. 73(1):23-30, 2013.
  • Kolenko, V.M., Teper, E., Kutikov, A., Uzzo, R.G.  Zinc and zinc transporters in prostate carcinogenesis. Nature Reviews Urology.  10(4):219-26, 2013.
  • Makhov, P., Golovine, K., Kutikov, A., Teper, E., Canter, D.J., Simhan, J., Uzzo, R.G., Kolenko, V.M.  Modulation of Akt/mTOR Signaling Overcomes Sunitinib Resistance in Renal and Prostate Cancer Cells.  Mol Cancer Ther. 11(7):1510-7, 2012.
  • Makhov, P., Golovine, K., Canter, D.J., Kutikov, A., Simhan, J., Corlew, M.M., Uzzo, R.G., Kolenko, V. Co-Administration of Piperine and Docetaxel Results in Improved Anti-Tumor Efficacy via Inhibition of CYP3A4 Activity. The Prostate. 72(6):661-7, 2012. 
  • Kutikov, A., Makhov, P., Golovine, K., Canter, D.J., Mohit, S., Street, R., Simhan, J., Uzzo, R.G., Kolenko, V. Interleukin-6: A Potential Biomarker of Resistance to Multitargeted Receptor Tyrosine Kinase Inhibitors in Castration-Resistant Prostate Cancer. Urology. 78(4):968.e7-968.e11, 2011.
  • Makhov, P., Golovine, Kutikov, A., K., Canter, D.J., Rybko, V., Roshchin, D., Matveev, V., Uzzo, R.G., Kolenko, V.  Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells. Carcinogenesis. 32(12):1773-81,2011.
  • Makhov, P., Golovine, K., Uzzo, R.G., Rothman, J., Crispen, P., Shaw, T., Scoll, B.J., Kolenko, V.M.  Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis (XIAP) and sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Cell Death and Differentiation.  15(11):1745-1751, 2008.
    Golovine, K., Makhov, P., Uzzo, R.G., Shaw, T., Kunkle, D., Kolenko, V.M.  Overexpression of the zinc uptake transporter hZIP1 inhibits NF-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. Clinical Cancer Research. 14(17):5376-5384, 2008.
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  • Golovine, K., Makhov, P., Teper, E., Kutikov, A., Canter, D., Uzzo, R.G., Kolenko, V.M.  Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate. 73(1):23-30, 2013.
  • Kolenko, V.M., Teper, E., Kutikov, A., Uzzo, R.G.  Zinc and zinc transporters in prostate carcinogenesis. Nature Reviews Urology.  10(4):219-26, 2013.
  • Teper, E., Makhov, P., Golovine, K., Canter, D.J., Myers, C.B., Kutikov, A., Uzzo, R.G., Kolenko, V.M.  The Effect of 5-Aminolevulinic Acid and its Derivatives on Protoporphyrin IX Accumulation and Apoptotic Cell Death in Castrate-Resistant Prostate Cancer Cells. Urology. 80(6):1391.e1-7, 2012.
  • Makhov, P., Golovine, K., Kutikov, A., Teper, E., Canter, D.J., Simhan, J., Uzzo, R.G., Kolenko, V.M.  Modulation of Akt/mTOR Signaling Overcomes Sunitinib Resistance in Renal and Prostate Cancer Cells.  Mol Cancer Ther. 11(7):1510-7, 2012.
  • Makhov, P., Golovine, K., Canter, D.J., Kutikov, A., Simhan, J., Corlew, M.M., Uzzo, R.G., Kolenko, V. Co-Administration of Piperine and Docetaxel Results in Improved Anti-Tumor Efficacy via Inhibition of CYP3A4 Activity. The Prostate. 72(6):661-7, 2012. 
  • Makhov, P., Kutikov, A., Golovine, K., Uzzo, R.G., Canter, D.J., Kolenko, V. Docetaxel-mediated Apoptosis in Myeloid Progenitor TF-1 Cells is Mitigated by Zinc:  Potential Implication for Prostate Cancer Therapy. The Prostate.  71(13):1413-9, 2011.
  • Canter, D.J., Kutikov, A., Golovine, K., Makhov, P., Simhan, J., Uzzo, R.G., Kolenko, V. Are All Multi-targeted Tyrosine Kinase Inhibitors Created Equal? An In Vitro Study of Sunitinib and Pazopanib in Renal Cell Carcinoma Cell Lines. The Canadian Journal of Urology.  18(4):5819-25, 2011.
  • Kutikov, A., Makhov, P., Golovine, K., Canter, D.J., Mohit, S., Street, R., Simhan, J., Uzzo, R.G., Kolenko, V. Interleukin-6: A Potential Biomarker of Resistance to Multitargeted Receptor Tyrosine Kinase Inhibitors in Castration-Resistant Prostate Cancer. Urology. 78(4):968.e7-968.e11, 2011.
  • Makhov, P., Golovine, Kutikov, A., K., Canter, D.J., Rybko, V., Roshchin, D., Matveev, V., Uzzo, R.G., Kolenko, V.  Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells. Carcinogenesis. 32(12):1773-81,2011.
  • Golovine K, Makhov P, Uzzo RG, Kutikov A, Kaplan DJ, Fox E, Kolenko V. Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-κB-independent, proteasome-mediated mechanism. Molecular Cancer. 2010;9(1):183.
  • Makhov P, Golovine K, Uzzo RG, Wuestefeld T, Scoll BJ, Kolenko VM. Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells. Gene. 2008;431(1-2):39-46.
  • Golovine K, Makhov P, Uzzo RG, Shaw T, Kunkle D, Kolenko VM. Overexpression of the zinc uptake transporter hZIP1 inhibits NF-κB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. Clin Cancer Res, 2008;14: 5376-84.
  • Makhov P, Golovine K, Uzzo RG, Rothman J, Crispen PL, Shaw T, Scoll BJ. Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Cell Death Differ, 2008;15(11):1745-51.
  • Golovine K, Uzzo RG, Makhov P, Crispen PLP, Shaw T, Kunkle D, Kolenko VM. Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB- dependent pathway. Prostate. 2008;68:1443-9.
  • Uzzo RG, Haas NB, Crispen PL, Kolenko V. Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone refractory prostate cancer. Cancer. 2008;112 (8):1660-71.
  • Crispen PL, Uzzo RG, Golovine K, Makhov P, Pollack A, Horwitz EM, Greenberg RE, Kolenko VM. Vitamin E Succinate inhibits NF-κB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. Prostate. 2007;67 (6):582-90.
  • Uzzo RG, Crispen PL, Golovine K, Makhov P, Horwitz EM, Kolenko V. Diverse effects of zinc on transcriptional control of NF-kB and AP-1:implications for prostate cancer progression Carcinogenesis. 2006;27 (10):1980-90.
  • Yamaguchi K, Uzzo RG, Pimkina J, Golovine K, Makhov P, Kolenko VM. Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Oncogene. 2005;24:5868.
  • Uzzo RG, Brown JG, Horwitz EM, Hanlon A, Mazzoni S, Konski A, Greenberg RE, Pollack A, Kolenko VM, Watkins-Bruner D. Prevalence and patterns of self-initiated nutritional supplementation in men at high risk for prostate cancer. 2004;BJU Int 93 (7):955-60.
  • Yamaguchi K, Uzzo RG, Finke JH, Kolenko V. Renal carcinoma cells undergo apoptosis without oligonucleospmal DNA fragmentation. Biochem Biophys Res Commun. 2004;318(3):710-3.
  • Hogarth DK, Sandbo N, Taurin S, Kolenko V, Miano JM, Dulin NO. Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP. Am J Physiol Cell Physiol. 2004;287:C449-56.
  • Davis A, Hogarth K, Fernandes D, Solway J, Niu J, Kolenko V, Browning D, Miano JM, Orlov SN, Dulin NO. Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA. Cell Signal. 2003 Jun;15(6):597-604.
  • Uzzo RG, Cairns P, Al-Saleem T, Hudes G, Haas N, Greenberg RE, Kolenko V. The basic biology and immunobiology of renal cell carcinoma: considerations for the clinician. Urol Clin North Am. 2003 Aug;30(3):423-36.
  • Uzzo R, Bruner D, Horwitz E, Konski A, Pollack A, Engstrom P, Kolenko V. Prostate cancer prevention: strategies and realities. Prostate Cancer: Biology, Epidemiology and Therapeutic Modalities (Godec, C., Mydlo, J., editors), Academic Press, pp. 90-99, 2003.
  • Uzzo R, Cairns P, Dulin N, Horwitz E, Pollack A, Kolenko V. Tumor resistance to apoptosis: Mechanisms of evasion and implications for radiation and chemotherapeutic strategies. In Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done (Finke, J., editor). The Humana Press, Totowa, NJ, pp. 215-233, 2003.
  • Uzzo R, Leavis P, Hatch W, Gabai V, Dulin N, Zvartau N, Kolenko V. Zinc inhibits NF-B activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res. 2002;8:3579-83.
  • Niu J, Scheschonka A, Druey KM, Davis A, Reed E, Kolenko V, Bodnar R, Voyno-Yasenetskaya T, Du X, Kehrl J, Dulin NO. RGS3 interacts with 14-3-3 via the N-terminal region distinct from RGS domain. Biochem J. 2002 Aug 1;365(Pt 3):677-84.
  • Uzzo R, Dulin N, Bloom T, Bukowski R, Finke J, Kolenko V. Inhibition of NF-κB nuclear import induces caspase-independent cell death in human peripheral blood T lymphocytes. Biochem. Biophys. Res. Commun. 2002;287:895-9.
  • Gonzalez R, Leavis P, Ramos M, Kolenko V, Coulam C, Barnea E. Preimplantation factor may modulate maternal cellular immunity. Am J Reprod Immunol. 2001;46:68-9.
  • Finke J, Rayman P, George R, Tannenbaum C, Kolenko V, Uzzo R, Novick A, Bukowski R. Tumor-induced sensitivity to apoptosis in T cells from patients with renal cell carcinoma: role of nuclear factor-kappaB suppression. Clin Cancer Res. 2001;3:940s-946s.li>
  • Uzzo R, Kolenko V, Finke J, Novick A. T cell signal transduction abnormalities in patients with renal cell carcinoma. In Methods in Molecular Medicine: Renal Cancer – Methods and Protocols (Mydlo, J.H., editor). The Humana Press, Totowa, NJ, pp. 361-376, 2001.
  • Uzzo RG, Kolenko V, Froelich CJ, Tannenbaum C, Molto L, Novick AC, Bander NH, Bukowski R, Finke JH. T cell death knell: immune-mediated tumor death in renal cell carcinoma. Clin. Cancer Res. Clin Cancer Res. 2001 Oct;7(10):3276-81.
  • Kolenko VM, Uzzo RG, Dulin N, Hauzman E, Bukowski R, Finke JH. Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. Apoptosis. 2001 Dec;6(6):419-29.
  • Rayman P, Uzzo RG, Kolenko V, Bloom T, Cathcart MK, Molto L, Novick AC, Bukowski RM, Hamilton T, Finke JH. Tumor-induced dysfunction in interleukin-2 production and interleukin-2 receptor signaling: a mechanism of immune escape. Cancer J Sci Am. 2000 Feb;6 Suppl 1:S81-7.
  • Kolenko VM, Uzzo RG, Bukowski R, Finke JH. Caspase-dependent and ‑independent death pathways in cancer therapy. Apoptosis. 2000 Feb;5(1):17-20.
  • Uzzo RG, Rayman P, Kolenko V, Clark PE, Bloom T, Ward AM, Molto L, Tannenbaum C, Worford LJ, Bukowski R, Tubbs R, Hsi ED, Bander NH, Novick AC, Finke JH. Mechanisms of apoptosis in T cells from patients with renal cell carcinoma. Clin Cancer Res. 1999 May;5(5):1219-29.
  • Uzzo R, Rayman P, Kolenko V, Clark P, Bukowski R, Hamilton T, Finke J. Suppression of NF-κB activation in T cells by soluble products from renal cell carcinoma is mediated by tumor derived gangliosides. J Clin Invest. 1999;104:769-76.
  • Kolenko V, Rayman P, Roy B, Cathcart M, O’Shea J, Tubbs R, Bukowski R, Finke J. Downregulation of Jak3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic AMP-elevating agents: impact on IL2 receptor signaling pathway. Blood 1999;93:2308-8.
  • Kolenko V, Bloom T, Rayman P, Bukowski R, Hsi E, Finke J. Inhibition of NF-κB activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and ‑3. J Immunol. 1999;163:590-8.
  • Kolenko V, Uzzo R, Bukowski R, Bander N, Novick A, Hsi E, Finke J. Dead or dying: necrosis vs. apoptosis in caspases deficient human renal cell carcinoma. Cancer Res. 59:2838-2842, 1999.
  • Kolenko V, Wang Q, Riedy MC, O’Shea J, Ritz J, Cathcart M, Rayman P, Tubbs R, Edinger M, Novick A, Bukowski R, Finke J. Tumor induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL2R signaling: role of soluble products from human renal cell carcinomas. J Immunol. 1997;159:3057-67.
  • Kudoh S, Wang Q, Hidalgo OF, Rayman P, Tubbs RR, Edinger MG, Kolenko V, Panuto J, Bukowski R, Finke JH. Responses to T cell receptor/CD3 and interleukin-2 receptor stimulation are altered in T cells from B cell non-Hodgkin’s lymphomas. Cancer Immunol. Immunother. 1995;41:175-84.
  • Finke J, Kudoh S, Stanley J, Li X, Wang Q, Park J-K, Liu J, Kolenko V, Rayman P, Klein E, Tubbs R, Bukowski R. Impaired signal transduction in tumor infiltrating T cells from patients with renal cell carcinoma. Biology of Renal Cell Carcinoma (Bukowski, R.M., Finke, J.H., Klein, E.A., editors), Springer-Verlag, New York-Berlin-Heidelberg, pp. 72-83, 1995.
  • Wang Q, Stanley J, Kudoh S, Myles J, Kolenko V, Yi T, Tubbs R, Bukowski R, Finke J. T cells infiltrating non-Hodgkin’s B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present. J Immunol. 1995 Aug 1;155(3):1382-92.
  • Petrov AB, Kolenko VM, Koshkina NV, Zakirov MM, Bugaev LV, Semenova IB, Wiertz EJ, Poolman JT. Non-specific modulation of the immune response with liposomal meningococcal lipopolysaccharide: role of different cells and cytokines. Vaccine. 1994 Sep;12(12):1064-70.
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