Samuel Litwin, PhD
Office Phone: 215-728-2724
Interpretation of clinical or biological data often requires a mathematical or statistical model. Such models can increase the power of experiments to decide between clinical treatments or to evaluate hypotheses, especially when their ramifications are explored through computation. Examples of study design and analysis using minimal information are given.Description of research projects
- Mason WS, Xu C, Low HC, Saputelli J, Aldrich CE, Scougall C, Grosse A, Colonno R, Litwin S, Jilbert AR. The amount of hepatocyte turnover that occurred during resolution of transient hepadnavirus infections was lower when virus replication was inhibited with Entecavir. J Virol. In Press. PubMed
- Mason WS, Litwin S, Jilbert AR. Immune selection during chronic hepadnavirus infection. Hepatology International. 2008;2:3-16.
- Litwin S, Wong Y-N, Hudes G. Early stopping designs based on progression free survival at an early time point in the initial cohort. Stat Med. 2007;26:4400-4015. PubMed
- Litwin S, Toll E, Jilbert AR, Mason WS. The competing roles of virus replication and hepatocyte death rates in the emergence of drug-resistant mutants: Theoretical considerations. J Clin Virol. 2005;35:S96-S107. PubMed
- Zhang YY, Zhang BH, Theeli D, Litwin S, Toll E, Summers J. Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver. Proc Natl Acad Sci USA. 2003;100:12372-12377. PubMed