Faculty Summaries
Samuel Litwin, PhD
Samuel Litwin, PhD
Associate Professor
Office Phone: 215-728-2724

Principal Publications

  • Cauchi C, Somaiah N, Engstrom PF, Litwin S, Lopez M, Lee J, Davey M, Bove B, von Mehren M. Evaluation of nilotinib in advanced GIST previously treated with imatinib and sunitinib. Cancer Chemother Pharmacol. 2011; 69(4):977-82.
  • Doss M, Egleston BL, Litwin S. Comments on "Studies of the Mortality of Atomic Bomb Survivors Report 14 1950-2003: An Overview of Cancer and Noncancer Diseases" (Radiat Res 2012; 177:229-43) Radiat Res. Forthcoming 2012.
  • Freedman GM, Anderson PR, Bleicher RJ, Litwin S, Li T, Swaby RF, Ma CM, Li J, Sigurdson ER, Watkins-Bruner D, Morrow M, Goldstein LJ. Five-year local control in a Phase II study of hypofractionated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer. Int J Radiat Oncol Biol Phys. Forthcoming 2012.
  • Hensley HH, Roder NA, O'Brien SW, Bickel LE, Xiao F, Litwin S, Connolly DC. Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 2012; 14(6):451-62.
  • Ratushny V, Pathak HB, Beeharry N, Tikhmyanova N, Xiao F, Li T, Litwin S, Connolly DC, Yen TJ, Weiner LM, Godwin AK, Golemis EA. Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. Oncogene 2012; 31(10):1217-27.
  • Sill M, Rubinstein L, Litwin S, Yothers G. A method for utilizing bivariate efficacy outcome measures to screen regimens for activity in 2-stage phase II clinical trials. Clin Trials. 2012; 9(4):385-95.
  • Wong YN, Litwin S, Vaughn D, Cohen S, Plimack ER, Lee J, Song W, Dabrow M, Brody M, Tuttle H, Hudes G. Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma. J Clin Oncol. Forthcoming 2012.
  • Silvers RM, Smith JA, Schowalter M, Litwin S, Liang Z, Geary K, Daniel R. Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein. Hum Gene Ther. 2010; 3:337-49.
  • Cohen RJ, Paskalev K, Litwin S, Price Jr RA, Feigenberg SJ, Konski AA. Esophageal motion during radiotherapy: quantification and margin implications. Dis Esophagus, 2010; 3:33-42.
  • Mason WS, Liu C, Aldrich CE, Litwin S, Yeh MM. Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection. J Virol. 2010; 84:8308-15.
  • vonHolzen U, Chen T, Boquoi A, Richter JE, Falk GW, Klein-Szanto AJ, Cooper H, Litwin S, Weinberg DS, Enders GH. Evidence for DNA damage checkpoint activation in barrett esophagus. Transl Oncol. 2010; 3:33-42.
  • Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. Proprotein convertase inhibition and results in decreased skin cell proliferation tumorigenesis and metastasis. Neoplasia. 2010; 12:516-26.
  • Mason WS, Xu C, Low HC, Saputelli J, Aldrich CE, Scougall C, Grosse A, Colonno R, Litwin S, Jilbert AR. The amount of hepatocyte turnover that occurred during resolution of transient hepadnavirus infections was lower when virus replication was inhibited with Entecavir. J Virol. 2009; 83(4):1778-89.
  • Ke E, Patel BB, Liu T, Li XM, Haluszka O, Hoffman JP, Ehya H, Young NA, Watson JC, Weinberg DS, Nguyen MT, Cohen SJ, Meropol NJ, Litwin S, Tokar JL, Yeung AT. Proteomic analyses of pancreatic cyst fluids. Pancreas. 2009; 38(2):e33-42.
  • Sharkey RM, Karacay H, Johnson CR, Litwin S, Rossi EA, McBride WJ, Chang CH, Goldenberg DM. Pretargeted versus directly targeted radioimmunotherapy combined with anti-CD20 antibody consolidation therapy of Non-Hodgkin lymphoma. J Nucl Med. 2009; 50(3):444-53.
  • Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A. One-hit effects in cancer: Altered proteome of morphologically normal colon crypts in Familial Adenomatous Polyposis. Cancer Res. 2008; 68:7579-86.
  • Denlinger CS, Blanchard R, Xu L, Bernaards C, Litwin S, Spittle C, Berg DJ, McLaughlin S, Redlinger M, Dorr A, Hambleton J, Holden S, Kearns A, Kenkare-Mitra S, Lum B, Meropol NJ, O’Dwyer PJ. Pharmacokinetic analysis of irinotecan plus bevacizumab in patients with advanced solid tumors. Chancer Chemother Pharmacol. 2009; 65(1):97-05.
  • Mason WS, Low HC, Xu C, Aldrich CE, Scougall CA, Grosse A, Clouston A, Chavez D, Litwin S, Peri S, Jilbert AR, Lanford RE. Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection. J Virol. 2009; 83:8396-08.
  • Quinn BA, Brake T, Hua X, Baxter-Jones K, Litwin S, Ellenson HL, Connolly DC. Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p52. PLoS One. 2009; 4:e8404.
  • Mason WS, Litwin S, Jilbert AR. Immune selection during chronic hepadnavirus infection Hepatology Internatl. 2008; 2:3-16.
  • Clapper ML, Gary MA, Coudry RA, Litwin S, Chang WL, Devarajan K, Lubet RA, Cooper HS. 5-Aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of Azoxymethane/Dextran Sulfate Sodium-induced colitis. Inflamm Bowel Dis. 2008; 14(10):1341-47.
  • Sharkey RM, Karacay H, Litwin S, Rossi EA, McBride, WJ, Chang CH, Goldenberg DM. Improved therapeutic results by pretargeted radioimmunotherapy of non-Hodgkin's lymphoma with a new recombinant trivalent anti-CD20 bispecific antibody. Cancer Res. 2008; 68:5282-90.
  • Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A. One-hit effects in cancer: Altered proteome of morphologically normal colon crypts in Familial Adenomatous Polyposis. Cancer Res. 2008; 68:7579-86.
  • Borghaei H, Langer CJ, Millenson M, Ruth KJ, Litwin S, Tuttle H, Seldomridge JS, Rovito M, Mintzer D, Cohen R, Treat J. Phase II study of paclitaxel carboplatin and cetuximab as first line treatment for patients with advanced non-small (NSCLC): results of OPN-017. J. Thorac. Oncol. 2008; 3:1286-92.
  • Mason WS, Litwin S, Xu C, Jilbert AR. Hepatocyte turnover in transient and chronic hepadnavirus infections. J Viral Hepat. 2007; 14: Suppl 1:22-28.
  • Mason WS, Litwin S, Jilbert AR. Immune selection during chronic hepadnavirus infection. Hepatology International. 2008;2:3-16.
  • Litwin S, Wong Y-N, Hudes G. Early stopping designs based on progression free survival at an early time point in the initial cohort. Stat Med. 2007;26:4400-4015.
  • Litwin S, Toll E, Jilbert AR, Mason WS. The competing roles of virus replication and hepatocyte death rates in the emergence of drug-resistant mutants: Theoretical considerations. J Clin Virol. 2005;35:S96-S107.
  • Zhang YY, Zhang BH, Theeli D, Litwin S, Toll E, Summers J. Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver. Proc Natl Acad Sci USA. 2003;100:12372-12377.
  • Summers J, Jilbert AR, Yang W, Aldrich CE, Saputelli J, Litwin S, Toll E, Mason WS. Hepatocyte turnover during resolution of a transient hepadnaviral infection. Proc Natl Acad Sci USA. 2003;100:11652-11659.
  • Mintz B, Anthony K, Litwin S. Monoclonal derivation of mouse myeloid and lymphoid lineages from totipotent hematopoietic stem cells experimentally engrafted in fetal hosts. Proc Natl Acad Sci USA. 1984;81:7835-7839.
  • Lustbader E, Litwin S. The design of censored survival studies. Biometrics 1981;37:697-704.
  • Englander SW, Kallenbach NR, Heeger AJ, Krumhansl JA, Litwin S. Nature of the open state in long polynucleotide double helices: the possibility of soliton excitations. Proc Natl Acad Sci, USA. 1980;77(12):7222-7226.
  • Litwin S. Monte Carlo simulation of particle adsorption rates at high cell concentrations. Biophys J. 1980;31:271-278.
  • Litwin S. The lengths of fragments covering a fixed marker in randomly cut linear or circular DNA. J Appl Probab. 1979;16:721-731.
  • Litwin S. The distribution of the shortest distance between random cuts on opposite strands of DNA. J Appl Probab. 1974;11:363-368.
  • Litwin S, Kallenbach NR. Kinetics of DNA replication in bacteria with heterogeneous generation times. J Theoret. Biol. 1970 27:357-376.
  • Litwin S, Shahn E, Kozinski AW. Interpretation of sucrose gradient distributions for randomly cut DNA. J Virol. 1969 4:24-30.
  • Gibbons J, Litwin S. Estimation of the number of critical sites in limited genome expression during viral infection of bacteria. Biometrics. 1969;25:537-544.
  • Litwin S. The distribution of radioactive recovery in randomly cut and sedimented DNA. J Appl Probab. 1969;6:275-284.