Glenn F. Rall, PhD
Office Phone: 215-728-3617
Lab Phone: 215-728-3677
Viral Infection, Immunity, and Disease in the Brain
- Elucidating how neurotropic viruses spread to, and across, synaptic junctions
- Defining principles that govern unique aspects of the host immune response within the brain
- Developing mouse models to study immunity to multiple pathogenic encounters
- Evaluating long-term neuropathological consequences of viral infections
Fox Chase Programs
- O’Donnell, L.A., K. M. Henkins, A. Kulkarni, C. M. Matullo, S. Balachandran, A. K. Pattisapu, G. F. Rall. Interferon gamma induces protective, non-canonical signaling pathways in primary neurons. J. Neurochem., in press.
- Miller, K.D., Holmgren, A.M., S.E. Cavanaugh, G.F. Rall. Bone marrow stromal antigen-2 (Bst2)/tetherin is induced by type I interferon and viral infection, but is dispensable for protection against neurotropic viral challenge. J. Virology, in press.
- Cavanaugh, S.E., A.M. Holmgren, G.F. Rall. Homeostatic interferon expression in neurons is sufficient for early control of viral infection. J. Neuroimmunol, 279: 11-19, 2015. PMCID: pending.
- Thapa, R.J., S. Nogusa, P. Chen, J.L. Maki, A. Lerro, M. Andrake, G.F. Rall, A. Degterev, S. Balachandran. Interferon-induced RIP1/RIP3-dependent necrosis requires PKR and is licensed by FADD and caspases. Proc. Natl. Acad. Sci., 110: E3109-118, 2013. PMC3746924
- O'Donnell, L.A., S. Conway, R.W. Rose, E. Nicolas, M. Slifker, S. Balachandran, G.F. Rall. STAT-1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice. J. Immunol., 188 (4): 1915-1923, 2012. PMCID: PMC3273675
- Gomme, E.A., C. Wirblich, S. Addya, G.F. Rall, M.J. Schnell. Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression. PLoS Pathogens, 8 (10): e1002971, 2012. PMCID: PMC3469654
- Matullo, C.M., K.J. O’Regan, M. Curtis, G.F. Rall. CNS Recruitment of CD8+ T Lymphocytes specific for a peripheral virus infection triggers neuropathogenesis during polymicrobial challenge. PLoS Pathogens, 7 (12): e1002462, 2011. PMCID: PMC3245314
- Matullo, C.M., K.J. O'Regan, M. Curtis, H. Hensley, G.F. Rall. Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation. J. Virol., 84: 312-320, 2010. PMCID: PMC2798401 PubMed
- Rose, R.W., A. Vorobyeva, J.D. Skipworth, E. Nicolas, G.F. Rall. Altered levels of STAT1 and STAT3 influence the neuronal response to interferon gamma. J. Neuroimmunol, 192: 145-156, 2007. PMCID: PMC2180831
- Makhortova, N., P. Askovich, C. E. Patterson, L. A. Gechman, N. P. Gerard, G. F. Rall. Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology, 362: 235-244, 2007. PMCID: PMC1945128 PubMed
- Patterson, C. E., J. K. Daley, L. A. Echols, T. E. Lane, G. F. Rall. Measles virus infection induces chemokine synthesis by neurons. J. Immunol. 171: 3102-3109, 2003.
- Patterson, C. E., D. M. Lawrence, L. A. Echols, G. F. Rall. Immune-mediated protection from measles virus-induced central nervous system disease is noncytolytic and gamma interferon dependent. J. Virol. 76:4497-4506, 2002. PMCID: PMC155105
- Lawrence, D.M.P., C. E. Patterson, T.L. Gales, M. M. Vaughn, G. F. Rall. Measles virus spread between neurons requires cell contact but not CD46 expression, syncytium formation or extracellular virus production. J. Virol. 74: 1908-1918, 2000. PMCID: PMC111669
- Lawrence, D.M.P., M. M. Vaughn, A. R. Belman, J. S. Cole, G. F. Rall. Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease. J. Virol. 73: 1795-1801, 1999.
- Rall, G. F., M. Manchester, L. Daniels, E. Callahan, A. Belman, M. B. A. Oldstone. A transgenic mouse model for measles virus infection of the brain. Proc. Natl. Acad. Sci. USA 94: 4659-4663, 1997. PMCID: PMC20780