Faculty Summaries
Glenn F Rall, PhD
Glenn F. Rall, PhD
  • Associate Academic Officer
  • Director, Postdoctoral Program
Office Phone: 215-728-3617
Lab Phone: 215-728-3677
Fax: 215-728-2412
Office: R493

Recent Publications

  • O’Donnell, L.A., K. M. Henkins, A. Kulkarni, C. M. Matullo, S. Balachandran, A. K. Pattisapu, G. F. Rall.  Interferon gamma induces protective, non-canonical signaling pathways in primary neurons.  J. Neurochem., in press.
  • Miller, K.D., Holmgren, A.M., S.E. Cavanaugh, G.F. Rall.  Bone marrow stromal antigen-2 (Bst2)/tetherin is induced by type I interferon and viral infection, but is dispensable for protection against neurotropic viral challenge.  J. Virology, in press.
  • Cavanaugh, S.E., A.M. Holmgren, G.F. Rall.  Homeostatic interferon expression in neurons is sufficient for early control of viral infection.  J. Neuroimmunol, 279: 11-19, 2015.  PMCID: pending.
  • Thapa, R.J., S. Nogusa, P. Chen, J.L. Maki, A. Lerro, M. Andrake, G.F. Rall, A. Degterev, S. Balachandran.  Interferon-induced RIP1/RIP3-dependent necrosis requires PKR and is licensed by FADD and caspases.  Proc. Natl. Acad. Sci., 110: E3109-118, 2013.  PMC3746924
  • O'Donnell, L.A., S. Conway, R.W. Rose, E. Nicolas, M. Slifker, S. Balachandran, G.F. Rall.  STAT-1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice.  J. Immunol., 188 (4): 1915-1923, 2012. PMCID: PMC3273675
  • Gomme, E.A., C. Wirblich, S. Addya, G.F. Rall, M.J. Schnell.  Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression.  PLoS Pathogens, 8 (10):  e1002971, 2012. PMCID: PMC3469654
  • O'Donnell LA, Rall GF. "Blue moon neurovirology: the merits of studying rare CNS diseases of viral origin" J Neuroimmune Pharmacol. 2010 Sep;5(3):443-55.
  • Matullo CM, O'Regan KJ, Hensley H, Curtis M, Rall GF. Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation. J Virol. 2010 Jan;84(1):312-20.

Publications 1984-2009

  • Rose RW, Skipworth JD, Nicolas E, Rall GF. Distinct STAT activation and transcriptional response in interferon-gamma stimulated primary CNS neurons, J Neuroimmunol. 2007;192:145-156.
  • Makhortova, N, Askovich P, Patterson CE, Gechman LA, Gerard NP, Rall GF. Neurokinin-1 enables measles virus trans-synaptic spread in neurons. Virology. 2007;362:235-244.
  • Makhortova NR, Rall GF, Prasolov VS. Receptor-independent spread of the measles virus is unique to neurons and involves fusion of synaptic membranes. Molec Biol. 2007;41:168-170.
  • Gussow AM, Giordani NV, Tran RK, Imai Y, Kwiatkowski DL, Rall GF, Margolis TP, Bloom DC. Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice. J Virol. 2006 80:9414-9423.
  • Daley JK, Gechman LA, Skipworth J, Rall GF. Poliovirus replication and spread in primary neuron cultures. Virology. 2005;340:10-20.
  • Greger JG, Katz RA, Taganov K, Rall GF, Skalka AM. Transduction of terminally differentiated neurons by avian sarcoma virus. J Virol. 2004;78:4902-4906.
  • Patterson CE, Daley JK, Echols LA, Lane TE, Rall GF. Measles virus infection induces chemokine synthesis by neurons. J Immunol. 2003;171:3102-3109.
  • Phillips JJ, Chua MM, Rall GF, Weiss SM. Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation and virus-induced immunopathology in the central nervous system. Virology. 2002;301:109-120.
  • Katz RM, Greger JG, Darby K, Boimel P, Rall GF, Skalka AM. Transduction of interphase cells by avian sarcoma virus. J Virol. 2002;76:5422-5434.
  • Patterson CE, D. Lawrence M, Echols LA, Rall GF. Immune-mediated protection from measles virus-induced CNS disease is noncytolytic and interferon gamma-dependent. J Virol. 2002;76:4497-4506.
  • Kappes DJ, Lawrence DMP, Vaughn MM, Davé VP, Belman AR, Rall GF. Protection of CD3 delta knockout mice from lymphocytic choriomeningitis virus-induced immunopathology: implications for viral neurotropism. Virology. 2000;269:248-256.
  • Lawrence DMP, Patterson CE, Gales T, Vaughn MM, Rall GF. Measles virus spread in neurons requires cell contact but not CD46 expression, syncytia formation or extracellular virus production. J Virol. 2000;74:1908-1918.
  • Lawrence DMP, Vaughn M, Belman A, Cole J, Rall GF. Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease. J Virol. 1999;73:1795-1801.
  • Pugh JC, Guo JT, Aldrich C, Rall G, Kajino K, Tennant B, England JM, Mason WS. Aberrant expression of a cytokeratin in a subset of hepatocytes during chronic WHV infection. Virology. 1998;249:68-79.
  • Brot MD, G. Rall F, Oldstone MBA, Koob GF, Gold LH. Cognitive deficit remains following clearance of persistent viral infection in mice. J Neurovirol. 1997;3:265-273.
  • Rall GF, Manchester M, Daniels L, Callahan E, Belman A, Oldstone MBA. A transgenic mouse model of measles virus infection of the brain. Proc Natl Acad Sci USA. 1997;94:4659-63.
  • Rall GF, Mucke L, Oldstone MBA. Consequences of cytotoxic T lymphocyte interaction with MHC class I-expressing neurons in vivo. J Exp Med. 1995;182:1201-12.
  • Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, Oldstone MBA. Neuron specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron. 1995;15:1183-1197.
  • Tishon T, Lewicki H, Rall GF, von Herrath M, Oldstone MBA. An essential role for type 1 interferon gamma in terminating persistent viral infection. Virology. 1995;212:244-250.
  • Rall GF, Mucke L, Nerenberg M, Oldstone MBA. Expression of a major histocompatibility complex (MHC) class I transgene in astrocytes: presentation of viral antigens for cytotoxic T lymphocyte recognition. J Neuroimmunol. 1994;52:61-67.
  • Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 1994;367:188-193.
  • Rall GF, Evans CF, Killeen N, Littman D, Oldstone MBA. CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus. J Immunol. 1993;151:1-6.
  • de la Torre, JC, Rall GF, Oldstone C, Sanna P, Borrow P Oldstone MBA. Replication of lymphocytic choriomeningitis virus (LCMV) is restricted in terminally differentiated neurons. J Virol. 1993;67:7350-7359.
  • Rall GF, Kupershmidt S, Sugg N, Veach RS, Ben-Porat T. Function of the sequences at the ends of the inverted repeats of Pseudorabies virus. J Virol. 1992;66:1506-1519.
  • Kupershmidt S, Rall GF, Lu Z, Ben-Porat T. Cleavage of concatameric DNA at the natural junction of "translocation" mutants of Pseudorabies virus and inversion of their L component appear to be linked. Virology. 1992;187:223-232.
  • Rall GF, Lu Z, Sugg N, Veach RS, Ben-Porat T. The acquisition of an additional internal cleavage site differentially affects the ability of Pseudorabies virus to multiply in different host cells. J Virol. 1991;65:6604-6610.
  • Rall GF, Kupershmidt S, Lu Z, Mettenleiter TC, Ben-Porat T. Low level inversion of the L component of Pseudorabies virus is not dependent on sequence homology. J Virol. 1991;65:7016-7019.
  • Reilly, LM, Rall GF, Lomniczi B, Mettenleiter TC, Kupershmidt S, Ben-Porat T. The ability of Pseudorabies virus to grow in different hosts is affected by the duplication and translocation of sequences from the left end of the genome to the UL-US junction. J Virol. 1991;65:5839-5845.
  • DeMarchi JM, Lu Z, Rall G, Kupershmidt S, Ben-Porat T. Structural organization of the termini of the L and S components of the genome of Pseudorabies virus. J Virol. 1990;64:4968-4977.
  • Lu Z, J. DeMarchi M, Harper L, Rall GF, Ben-PoratT. Nucleotide sequence at recombinational junctions present in Pseudorabies virus variants with an invertible L component. J Virol. 1989;63:2690-2698.
  • Mineo L, Majumdar SK, Rall GF, Francis J, Segal A, Mrowca AM. Preliminary study of the ectomycorrhizal distribution of white oaks in eastern Pennsylvania forests. Proceedings of the Pennsylvania Academy of Science. 1984;58:92-98.
  • Majumdar SK, Rall G, Mrowca A, Steed P, Tabak J, Mineo L. Bacteriological survey of two acid-stressed lakes in the Poconos before limestone application. Proceedings of the Pennsylvania Academy of Science. 1984;58:181-186.

Recent Solicited Reviews

  • Young VA, Rall GF. Making it to the synapse: measles virus spread in and among neurons. Curr Topics Microbiol Immunol. 2008;330:3-30.
  • Matullo CK, Rall GF. Immunological wrong turns in the face of multiple viral infections. Future Virology (launch issue). 2006;1:37-45.
  • Rall GF. Measles virus 1998-2002: progress and controversy. Annual Reviews of Microbiology. 2003;57:343-367.
  • Patterson CE, Daley JK, Rall GF. Neuronal survival skills in the face of viral infection. J Infectious Diseases. 2002;186:S215-S219.
  • Evans CF, Redwine JM, Patterson CE, Askovic S, Rall GF. LCMV and the central nervous system; uncovering basic principles of CNS physiology and virus-induced disease. Curr Top Microbiol Immunol. 2002;263:177-195.
  • Manchester M and Rall GF. Transgenic mouse models for measles pathogenesis. Trends Microbiol. 2001;9:19-23.
  • Rall GF, Patterson CE, and Lawrence DMP. The application of transgenic and knockout technologies for the study of viral pathogenesis. Virology. 2000;271:220-226.
  • Rall GF. CNS neurons: the basis and benefits of low MHC expression.” Curr. Top. Microbiol. Immunol. 232: 115-134, 1998.
  • Rall GF and Oldstone MBA. Viral Persistence in the CNS. In Defense of the Brain. (Peterson PK and Remington JS, eds.), Blackwell Press, Cambridge, MA, pp. 273-289, 1997.
  • Rall GF and Oldstone MBA. Transgenic and knockout models of viral pathogenesis. Viral Pathogenesis. (Nathanson N, ed.), Raven Press, New York, pp. 507-531, 1996.
  • Rall GF and Oldstone MBA. Virus-neuron-cytotoxic T lymphocyte interactions. Curr Top Microbiol Immunol. 1995;202:261-273.
  • Oldstone MBA and Rall GF. Mechanism and consequence of viral persistence in cells of the immune system and neurons. Intervirology. 1993;35:116-121.