Faculty Summaries
Fabrice Roegiers, PhD
Fabrice Roegiers, PhD
Member & Assistant Professor
Office Phone: 215-728-5518
Lab Phone: 215-728-3513
Fax: 215-728-2412
Office: R356


  • Tikhmyanova N, Tulin AV, Roegiers F*, Golemis EA Dcas Supports Cell Polarization and Cell-Cell Adhesion Complexes in Development. PLoS One. 2010 Aug 24;5(8). pii: e12369.
  • Tong X, Zitserman D, Serebriiskii I, Andrake M, Dunbrack R, Roegiers F. Numb independently antagonizes sanpodo membrane targeting and notch signaling in Drosophila sensory organ precursor cells. Mol Biol Cell. 2010 Mar 1;21(5):802-10. Epub 2010 Jan.
  • Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, Morrison T, Nicolas E, Squillace R, Roegiers F, Henske EP. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest. 2010 Jan 4;120(1):93-102. * Corresponding author
  • Roegiers F, Kavaler J, Tolwinski N et al. Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks. Genetics. 2009;182(1):407-10.
  • Stone MC, Roegiers F, Rolls MM. Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila Neurons. Mol Biol Cell. 2008 Oct;19(10):4122-9.
  • Pugacheva EN, Roegiers F, Golemis EA. Interdependence of cell attachment and cell cycle signaling. Curr Opin Cell Biol. 2006;18(5):507-15.
  • Roegiers F, Jan LY, Jan YN. Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell. 2005;16 (8):3480-7.
  • Lai EC, Roegiers F, Qin X et al. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development. 2005;132(10):2319-32.
  • Prodon F, Dru P, Roegiers F et al. Polarity of the ascidian egg cortex and relocalization of cER and mRNAs in the early embryo. J Cell Sci. 2005;118(Pt 11):2393-404.
  • Moore AW, Roegiers F, Jan LY et al. Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. Genes Dev. 2004;18(6):623-8.
  • Roegiers F, Jan YN. Asymmetric cell division. Curr Opin Cell Biol. 2004;16(2):195-205.
  • Justice N, Roegiers F, Jan LY et al. Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr Biol. 2003;13(9):778-83.
  • Roegiers F. Insights into mRNA transport in neurons. Proc Natl Acad Sci USA. 2003;100(4):1465-6.
  • Roegiers F, Younger-Shepherd S, Jan LY et al. Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila. Proc Natl Acad Sci USA. 2001a;98(25):14469-74.
  • Roegiers F, Younger-Shepherd S, Jan LY et al. Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. Nat Cell Biol. 2001b;3(1):58-67.
  • Lu B, Roegiers F, Jan LY et al. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature. 2001;409(6819):522-5.
  • Roegiers F, Jan YN. Staufen: a common component of mRNA transport in oocytes and neurons? Trends Cell Biol. 2000;10(6):220-4.
  • Roegiers F, Djediat C, Dumollard R et al. Phases of cytoplasmic and cortical reorganizations of the ascidian zygote between fertilization and first division. Development. 1999;126(14):3101-17.
  • Sardet C, Roegiers F, Dumollard R et al. Calcium waves and oscillations in eggs. Biophys Chem. 1998;72(1-2):131-40.
  • Fernandez J, Roegiers F, Cantillana V et al. Formation and localization of cytoplasmic domains in leech and ascidian zygotes. Int J Dev Biol. 1998;42(8):1075-84.
  • Roegiers F, McDougall A, Sardet C. The sperm entry point defines the orientation of the calcium-induced contraction wave that directs the first phase of cytoplasmic reorganization in the ascidian egg. Development. 1995;121(10):3457-66.
  • Suzuki K, Roegiers F, Tran P et al. Reversible regression of cytokinesis induced by Ca2+ ionophore. Biol Bull. 1995;189(2):201-2.
  • Roegiers F, Tran P, Inoue S. Mitosis, cleavage, and development of highly compressed sea urchin (Lytechinus variegatus) zygotes. Biol Bull. 1994;187(2):240-1.