Faculty Summaries
Stephen M. Sykes, PhD
Stephen M. Sykes, PhD
Assistant Professor
Office Phone: 215-728-3539
Lab Phone: 215-728-3563
Office: W364


  • Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C, and Fröhling S. 2012. Myeloid leukemogenesis by CDX2 involves repression of KLF4 and deregulated PPARg signaling. J Clin Invest. 2013 Jan 2;123(1):299-314. PMCID: PMC3533294.
  • Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA & SA Armstrong. 2012. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012 Sep 7;11(3):429-39. PMCID: Not yet available
  • Ferraro F, Lymperi S, Mendez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Lodi-Rizzini E, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT. Diabetes Impairs Hematopoietic Stem Cell Mobilization Through Alteration of Niche Function. Sci Transl Med. 2011 Oct 12;3(104):104ra101. PMCID: Not yet available
  • Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SA, Scholl C, Tothova Z, Attar E, Frohling S, DePinho RA, Gilliland DG, Armstrong SA, Scadden DT (2011). AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 2;146(5):697-708. PMCID: Not yet available
  • Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA. Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood. 2011 Sep 8;118(10):2849-56. Epub 2011 Jul 15. PMCID: PMC3172801
  • Cornejo MG*, Mabialah V*, Sykes SM*, Khandan T, Lo Celso C, Lopez C, Rivera- Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood. 2011 Aug 4;118(5):1264-73. Epub 2011, Jun 7. *Co-first authors. PMCID: PMC3152494
  • Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ 3rd, Schultz DC, McMahon SB. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J Biol Chem. 2011 Feb 11;286(6):4264-70. PMCID: PMC3039376
  • Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'Andrea A (2010). Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1.  Stem Cells. 2010 May 4. PMCID: PMC2910804
  • Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG (2010). The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood. 2010 Apr 29;115(17):3489-97. PMCID: PMC2867262
  • Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB (2009).  Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem. 2009 Jul 24;284(30):20197-205. Epub 2009 Jun 3.  PMCID: PMC2740446
  • Pietsch EC, Sykes SM, McMahon SB, Murphy ME (2008). The p53 family and programmed cell death. Oncogene 27(50):6507-21. PMCID: PMC2657599
  • Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB (2008). The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Molecular Cell 29(1):102-11. PMCID: PMC2254522
  • Mellert HS, Sykes SM, Murphy ME, McMahon SB (2007). The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain.  Cell Cycle 6(11):1304-6.
  • Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006). Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Molecular Cell 24(6):841-851. PMCID: PMC1766330
  • Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, Hua X (2004). Menin induces apoptosis in murine embryonic fibroblasts. J. Biol. Chem. 279(11):10685-10691. PMCID: PMC2858560
  • Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D;Andrea AD, Hua X (2003). Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res. 63(14):4204-10. PMCID: Not yet available
  • La P, Morgan TA, Sykes SM, Mao H. Schnepp RW, Petersen CD Hua X (2003). Fusion proteins of retinoid receptors antagonize TGF-beta-induced growth inhibition of lung epithelial cells. Oncogene. 22(2):198-210. PMCID: Not yet available