Faculty Summaries
Joseph R Testa, PhD, FACMG
Joseph R. Testa, PhD
Professor
  • Carol & Kenneth E. Weg Chair in Human Genetics
  • Chair, Mesothelioma Working Group
  • Co-Leader, Cancer Biology
  • Co-Leader, Personalized Kidney Cancer Therapy Keystone
  • Director, Genomics Facility
Joseph.Testa@fccc.edu
Office Phone: 215-728-2610
Fax: 215-214-1623
Office: P3037

2000 - present

  • Gutierrez A, Grebliunaite R, Feng H, Dahlberg S, Neuberg D, den Hertog J, Prochownik E, Testa JR, Kanki JP, Look AT. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T-ALL. J Exptl Med. (in press).
  • The Cancer Genome Atlas (TCGA) Research Network. Integrated Genomic Analyses of Ovarian Carcinoma. Nature. (in press).
  • Cheung M, Testa JR. Diverse mechanisms of AKT pathway activation in human malignancy. (review) Curr Cancer Drug Targets (in press).
  • Huang J, Zhang L, Greschock J, Colligon TA, Wang Y, Ward R, Katsaros D, Lassus H, Butzow R, Godwin AK, Testa JR, Nathanson KL, Gimotty PA, Coukos G, Weber BL, Degenhardt Y. Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome. Genes Chromosomes Cancer. May 11 2011 [Epub ahead of print].
  • Shukla A, Barrett TF, MacPherson MB, Hillegass JM, Fukagawa NK, Swain WA, O'Byrne KJ, Testa JR, Pass HI, Faux SP, Mossman BT. An ERK2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury. Am J Respir Cell Mol Biol. March 31 2011 [Epub ahead of print].
  • Chandra HS, Heisterkamp NC, Hungerford A, Morrisetts JJD, Nowell PC, Rowley JD, Testa, JR. Philadelphia Chromosome Symposium:Commemoration of the 50th anniversary of the discovery of the Ph chromosome. Cancer Genet. 2011;204:171-79 (Lead article and cover photo).
  • Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Nuemann-Domer E, Liu Z, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR. Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS ONE. 2011;6:e18828.
  • Below JE, Cox NJ, Fukagawa NK, Hirvonen A, Testa JR. Factors that impact susceptibility to fiber-induced health effects. J Toxicol Environ Health B Crit Rev. 2011;14:246-66.
  • Tan Y, Cheung M, Menges CW, Godwin AK, Testa JR. Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS2-AKT signaling. Cancer Res. 2010;70:9197-9206.
  • Shukla A, Hillegass JM, MacPherson MB, Beuschel SL, Vacek PM, Pass HI, Carbone M, Testa JR, Mossman BT. Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. Mol Cancer. 2010; 9:314.
  • Shukla A, Hillegass, JM, MacPherson MB, Beuschel SL, Vacek PM, Butnor KJ, Pass HI, Carbone M, Testa JR, Heintz NH, Mossman BT. ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. Int J Cancer. Nov. 12 2010 [Epub ahead of print].
  • Feng, H, Stachura, DL, White, RM, Gutierrez, A, Zhang, L, Sanda, T, Jette, CA, Testa, JR, Neuberg, DS, Langenau, DM, Kutok, JL., Zon, LI, Traver, D, Fleming, MD, Kanki, JP, Look, AT. T-cell lymphoblastic lymphoma cells express high levels of both BCL2 and ICAM1 leading to a blockade of tumor cell intravasation. Cancer Cell 2010;18:353-66.
  • Tan Y, You H, Coffey FJ, Wiest DL, Testa JR. Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis. 2010;48:531-39.
  • Cheung M, Pei J, Pei Y, Jhanwar SC, Pass HI, Testa JR. The promyelocytic leukemia zinc finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival. Oncogene. 2010; 29:1633-40.
  • Altomare DA, Rybak SM, Pei J, Maizel JV, Cheung M, Testa JR, Shogen K. Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent. BMC Cancer. 2010; 10:34.
  • Tan Y, You H, Wu C, Altomare DA, Testa JR. Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem. 2010; 285:6377-89.
  • Hillegass JM, Shukla A, Lathrop SA, MacPherson MB, Beuschel SL, Butnor KJ, Testa JR, Pass HI, Carbone M, Steele C, Mossman BT. Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model. Ann N Y Acad Sci. 2010; 1203:7-14.
  • Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010;17:249-61.
  • Pei J, Feder MM, Al-Saleem T, Liu Z, Liu A, Hudes GR, Uzzo RG, Testa JR. Combined classical cytogenetics and microarray-based genomic copy number analysis reveal frequent 3;5 rearrangements in clear cell renal cell carcinoma. Genes Chromosomes Cancer. 2010;49:610-19.
  • Menges CW, Chen Y, Mossman BT, Chernoff J, Yeung AT, Testa JR. A phosphotyrosine proteomic screen identifies multiple tyrosine kinase signaling pathways aberrantly activated in malignant mesothelioma. Genes Cancer. 2010;1:493-505.
  • Mabuchi S, Kawase C, Altomare DA, Morishige K, Hayashi M, Sawada K, Ito K, Terai Y, Nishio Y, Klein-Szanto AJ, Burger RA, Ohmichi M, Testa JR, Kimura T. Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary. Mol Cancer Ther. 2010;9:2411-22.
  • Piotrowski Z, Canter DJ, Kutikov A, Al-Saleem T, Pei J, Testa JR, Uzzo RG. Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms’ tumor variant. Can J Urol. 2010 Aug;17(4):5309-12.
  • Altomare DA, Zhang L, Di Cristofano A, Klein-Szanto AJ, Kumar R, Testa JR. GSK690693 delays tumor onset and progression in genetically-defined mouse models expressing activated Akt. Clin Cancer Res. Forthcoming 2009. 2010; 16:486-96 [article featured in journal Highlights section].
  • Shukla A, Bosenberg MW, MacPherson MB, Butnor KJ, Heintz NH, Pass HI, Carbone M, Testa JR, Mossman BT. Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. Am J Pathol. 2009;175:2197-206.
  • Menges CW, Altomare DA, Testa JR. FAS-Associated Factor 1 (FAF1): diverse functions and implications for oncogenesis. Cell Cycle. 2009;8:2528-34.
  • Capo-Chichi CD, Cai KQ, Testa JR, Godwin AK, Xu X-X. Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer. Mol Cell Biol. 2009;29:4766-77.
  • Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Nishio Y, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T. mTOR is a promising target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res. 2009;15:5404-13.
  • Timakhov RA, Tan Y, Rao M, Liu Z, Altomare DA, Pei J, Wiest DL, Favorova OO, Knepper JE, Testa JR. Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice. Genes Chromosomes Cancer. 2009;48:786-94.
  • Xu J, Testa JR. Distal-less homeobox 5, DLX5, promotes tumor cell proliferation by transcriptionally regulating MYC. J Biol Chem. 2009;284:20593-601.
  • Belinsky MG, Skorobogatko YV, Rink L, Pei J, Cai KQ, Vanderveer LA, Ridell D, Merkel E, Tarn C, Eisenberg BL, von Mehren M, Testa JR, Godwin AK. High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors. Genes Chromosomes Cancer. 2009;48:886-96.
  • Altomare DA, Menges CW, Pei J, Zhang L, Skele-Stump KL, Carbone M, Kane AB, Testa JR. Activated TNFα/NFκB signaling via down regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc Natl Acad Sci USA. 2009;106:3420-5.
  • Ivanov SV, Miller J, Lucito R, Tang C, Ivanova AV, Pei J, Carbone M, Cruz C, Beck A, Webb C, Nonaka D, Testa JR, Pass, HI. Genomic events associated with progression of pleural malignant mesotheliomA Int J Cancer 2009 Feb 1;124(3):589-99
  • Carbone M, Pannuti A, Zhang L, Testa JR, Bocchetta M. A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells. Cancer Res 2008 Nov 15;68(22):9488-96.
  • Yang H, Testa JR, Carbone M. Mesothelioma epidemiology, carcinogenesis and pathogenesis. Curr Treat Options Oncol. 2008 Jun;9(2-3):147-57.
  • Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, Testa JR, Eisenberg B, von Mehren M, Godwin AK. Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8387-92.
  • Tan Y, Timakhov RA, Rao M, Altomare DA, Xu J, Liu Z, Gao Q, Jhanwar SC, Di Cristofano A, Wiest DL, Knepper JE, Testa JR. A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res. 2008 Mar 1;68(5):1296-302.
  • Ramos-Nino ME, Blumen SR, Sabo-Attwood T, Pass H, Carbone M, Testa JR, Altomare BA, Mossman BT. HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. Am J Respir Cell Mol Biol. 2008 Feb;38(2):209-17.
  • Kindler HL, Bueno R, Testa JR. New biomarkers, surgical controversies, and rationally targeted therapies for malignant mesotheliomA In: ASCO 2008 Educational Book, American Society of Clinical Oncology, pp354-361, 2008.
  • Testa JR, Jhanwar SC. Genetic alterations in mesothelioma pathogenesis. In: Light, RW, Lee, YCG. (eds.), Textbook of Pleural Diseases, 2nd edition. London, UK: Hodder Arnold, pp. 125-134, 2008.
  • Johnson JE, Gettings EJ, Schwalm J, Pei JM, Testa JR, Litwin S, von Mehren M, Broccoli D. Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms. Cancer Res. 2007 Oct;67(19):9221-8.
  • Li J, Poulikakos PI, Dai Z, Testa JR, Callaway DJ, Bu Z. Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly. J Biol Chem. 2007 Sep 14;282(37):27086-99.
  • Mabuchi S, Altomare DA, Cheung M, Zhang L, Poulikakos PI, Hensley HH, Schilder RJ, Ozols RF, Testa JR. RAD001 Inhibits Human Ovarian Cancer Cell Proliferation, Enhances Cisplatin-Induced Apoptosis, and Prolongs Survival in an Ovarian Cancer Model. Clin Cancer Res. 2007 Jul 15;13(14):4261-70.
  • Garland LL, Rankin C, Gandara DR, Rivkin SE, Scott KM, Nagle RB, Klein-Szanto AJ, Testa JR, Altomare DA, Borden EC. Phase II study of erlotinib in patients with malignant pleural mesothelioma: A Southwest Oncology Group study. J Clin Oncol. 2007 Jun;25(17):2406-13.
  • Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T. mTOR Is a Promising Therapeutic Target Both in Cisplatin-Sensitive and Cisplatin-Resistant Clear Cell Carcinoma of the Ovary. Clin Cancer Res. 2009 Sep;15(17):5404-13.
  • Lee H, Kim D, Dan HC, Wu EL, Gritsko TM, Cao CH, Nicosia SV, Golemis EA, Liu WG, Coppola D, Brem SS, Testa JR, Cheng JQ. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol. 2007 Mar;27(6):2103-19.
  • Altomare DA, Testa JR. AKT2 (v-akt murine thymoma viral oncogene homolog 2). Atlas Genet Cytogenet Oncol Haematol, 2007. URL: http://atlasgeneticsoncology.org/Genes/AKT2ID517ch19q13.html
  • Cheung M, Testa JR. AKT3 (v-akt murine thymoma viral oncogene homolog 3, protein kinase B gamma). Atlas Genet Cytogenet Oncol Haematol, 2007. URL: http://atlasgeneticsoncology.org/Genes/AKT3ID615ch1q44.html
  • Varsano T, Dong MQ, Niesman I, Gacula H, Lou X, Ma T, Testa JR, Yates JR, Farquhar MG. GIPC is recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling. Mol Cell Biol. 2006 Dec;26(23):8942-52.
  • Lin DCC, Quevedo C, Brewer NE, Grimes ML, Testa JR, Miller FD, Kaplan, DR. APPL1 associates with TrkA and GIPC1, and is required for NGF-mediated signal transduction. Mol Cell Biol. 2006;26:8928-41.
  • Altomare BA, Testa JR. Cytogenic and molecular genetic changes in malignant mesothelioma. In: O'Byrne K, Rusch VW, editors. Malignant pleural mesothelioma. Oxford: Oxford University Press; 2006. p. 239-50.
  • Poulikakos PI, Xiao GH, Gallagher R, Jablonski S, Jhanwar SC, Testa JR. Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK. Oncogene. 2006 May 1;25(44):5960-8.
  • Pei JM, Kruger WD, Testa JR. High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays. Cancer Genet Cytogenet. 2006 Oct;170(1):65-8.
  • Yang HN, Bocchetta M, Kroczynska B, Elmishad AG, Chen YB, Liu ZM, Bubici C, Mossman BT, Pass HI, Testa JR, Franzoso G, Carbone M. TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappa B-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A. 2006 Jul;103(27):10397-402.
  • Ramos-Nino ME, Testa JR, Altomare DA, Pass HI, Carbone M, Bocchetta M, Mossman BT. Cellular and molecular parameters of mesothelioma. J Cell Biochem. 2006 Jul;98(4):723-34.
  • Yao K, Gietema JA, Shida S, Selvakumaran M, Fonrose X, Haas NB, Testa J, O'Dwyer PJ. In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo. Br J Cancer. 2005 Dec 12;93(12):1356-63.
  • Wei BL, Arora VK, Raney A, Kuo LS, Xiao GH, O'Neill E, Testa JR, Foster JL, Garcia JV. Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation. J Virol. 2005 Dec;79(23):14976-80.
  • Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005;24:7455-64.
  • Testa JR, Tsichlis PN. AKT signaling in normal and malignant cells. Oncogene. 2005;24:7391-3.
  • Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB, Testa JR. A mouse model recapitulating molecular features of human mesothelioma. Cancer Res. 2005 Sep 15;65(18):8090-5.
  • Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ. ArgBP2 gamma interacts with akt and p21 activated kinase-1 and promotes cell survival. J Biol Chem. 2005 Jun 3;280(22):21483-90.
  • Al-Saleem T, Balsara BR, Liu ZM, Feder M, Testa JR, Wu H, Greenberg RE. Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression?. Cancer Genet Cytogenet. 2005 Nov;163(1):81-5.
  • Altomare DA, You HH, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR. Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth. Oncogene. 2005 Sep 8;24(40):6080-9.
  • Bellacosa A, Kumar CC, Di Cristofano A, Testa JR. Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res. 2005;94:29-86.
  • Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol. 2005 Mar;25(6):2384-94.
  • Cacciotti P, Barbone D, Porta C, Altomare DA, Testa JR, Mutti L, Gaudino G. SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure. Cancer Res. 2005 Jun 15;65(12):5256-62.
  • Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A, Testa JR. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene. 2005;24(22):3574-82.
  • Apostolou S, Balsara B, Testa J. Cytogenetics of mesothelioma. In: Pass HI, Vogelzang NJ, Carbone M, editors. Malignant Mesothelioma. New York, NY: Springer-Science and Business Media; 2005. p. 101-11.
  • Stoyanova R, Clapper, ML, Bellacosa, A, Henske, EP, Testa, JR, Ross, EA, Yeung, AT, Nicolas, E, Tsichlis, N, Li, YS, Linehan. WM, Howard, S, Campbell, KS, Godwin, AK, Boman, BM, Crowell, JA, Kopelovich, L, Knudson, AG. Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther, 2004 3: 1313-1321.
  • Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, Ohta T, Kawagoe J, Takahashi K, Yada-Hashimoto N, Seino-Noda H, Sakata M, Motoyama T, Kurachi H, Testa JR, Tasaka K, Murata Y. Inhibition of inhibitor of nuclear factor-kappa B phosphorylation increase the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Clin Cancer Res. 2004 Nov 15;10(22):7645-54.
  • Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. 2004 Jul 29;23(34):5853-7.
  • Subhi AL, Tang B, Balsara BR, Altomare DA, Testa JR, Cooper HS, Hoffman JP, Meropol NJ, Kruger WD. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin Cancer Res. 2004;10:7290-6.
  • Al-Saleem T, Cairns P, Dulaimi EA, Feder M, Testa JR, Uzzo RG. The genetics of renal oncocytosis: a possible model for neoplastic progression. Cancer Genet Cytogenet. 2004 Jul;152(1):23-8.
  • Nechamen CA, Thomas RM, Cohen BD, Acevedo G, Poulikakos PI, Testa JR, Dias JA. Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: Potential involvement of the PI3K pathway in FSH signaling. Biol Reprod. 2004 Aug;71(2):629-36.
  • Lareef MH, Tahin Q, Song J, Russo IH, Mihaila D, Slater CM, Balsara B, Testa JR, Broccoli D, Grobelny JV, Mor G, Cuthbert A, Russo J. Chromosome. 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells. Mol. Carcinog. 2004;39:234-46.
  • Bellacosa A, Testa JR, Moore R, Larue L. A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities. Cancer Biol Ther. 2004 Mar;3(3):268-75.
  • Balsara BR Pei J, Mitsuuchi Y, Page R, Klein-Szanto A, Wang H, Unger M, Testa JR. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis. 2004;25:2053-9.
  • Hirokawa Y, Tikoo A, Huynh J, Utermark T, Hanemann CO, Giovannini M, Xiao GH, Testa JR, Wood J, Maruta H. A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Cancer J. 2004;10:20-6.
  • Tanno S, Yanagawa N, Habiro A, Koizumi K, Nakano Y, Osanai M, Mizukami Y, Okumura T, Testa JR, Kohgo Y. Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance. Cancer Res. 2004 May;64(10):3486-90
  • Razak ZR, Varkonyi RJ, Kulp-McEliece M, Caslini C, Testa JR, Murphy ME, Broccoli D. p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance. Mol Cell Biol. 2004 Jul;24(13):5967-77.
  • Apostolou S, Klein JO, Mitsuuchi Y, Shetler JN, Poulikakos PI, Jhanwar SC, Kruger WD, Testa JR. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and its dependence on selenoprotein SEP15 genotype. Oncogene. 2004;23:5032-40.
  • Xiao G-H, Chernoff J, Testa JR. NF2: the wizardry of merlin. Genes Chromosomes Cancer. 2003;38:389-99.
  • Testa JR, Hino O. Tumor suppressor genes and the two-hit model of recessive oncogenesis: Celebrating Alfred Knudson's 80th birthday. Genes Chromosomes Cancer. 2003 Dec;38(4):286-7.
  • Carbone M, Bocchetta M, Cristaudo A, Emri S, Gazdar A, Jasani B, Lednicky J, Miele L, Mutti L, Pass HI, Ramael M, Rizzo P, Testa JR, Weggen S, Yeung A. SV40 and human brain tumors. Int J Cancer. 2003 Aug;106(1):140-2.
  • Testa JR, Jhanwar SC. Molecular genetics of malignant mesothelioma. In: Light RW, Lee G, editors. Pleural Disease: An International Textbook. London, UK: Arnold Publishers; 2003. p. 120-30.
  • Karbowniczek M, Astrinidis A, Balsara BR, Testa JR, Lium JH, Colby TV, McCormack FX, Henske EP. Recurrent lymphangiomyomatosis after transplantation - Genetic analyses reveal a metastatic mechanism. Am J Respir Crit Care Med. 2003 Apr;167(7):976-82.
  • Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Skele KL, Hoffman JP, Testa JR. Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem. 2003 Jan 1;88(1):470-6.
  • Mitsuuchi, Y, Testa, JR Cytogenetics and molecular genetics of lung cancer. Am. J. Med. Genet. 2002 115:183-188.
  • Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. J Biol Chem. 2002 Nov 22;277(47):45361-70.
  • Balsara BR, Testa JR. Chromosomal imbalances in human lung cancer. Oncogene. 2002 Oct 7;21(45):6877-83.
  • Baser ME, De Rienzo A, Altomare D, Balsara BR, Hedrick NM, Gutmann DH, Pitts LH, Jackler RK, Testa JR. Neurofibromatosis 2 and malignant mesothelioma. Neurology. 2002 Jul 23;59(2):290-1.
  • De Rienzo A, Tor M, Sterman DH, Aksoy F, Albelda SM, Testa JR. Detection of SV40 DNA sequences in malignant mesothelioma specimens from the United States, but not from Turkey. J Cell Biochem. 2002;84(3):455-9.
  • Xiao GH, Beeser A, Chernoff J, Testa JR. p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem. 2002 Jan 11;277(2):883-6.
  • Bacus SS, Altomare DA, Lyass L, Chin DM, Farrell MP, Gurova K, Gudkov A, Testa JR. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene. 2002;21:3532-40.
  • Sumitani S, Goya K, Testa JR, Kouhara H, Kasayama S. Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts. Endocrinology. 2002 Mar;143(3):820-8.
  • Foddis R, De Rienzo A, Broccoli D, Bocchetta M, Stekala E, Rizzo P, Tosolini A, Grobelny JV, Jhanwar SC, Pass HI, Testa JR, Carbone M. SV40 infection induces telomerase activity in human mesothelial cells. Oncogene. 2002 Feb 21;21(9):1434-42.
  • Carbone M, Kratzke RA, Testa JR. The pathogenesis of mesotheliomA Semin. Oncol 2002;29:2-17.
  • Balsara BR, Pei J, Testa JR. Comparative genomic hybridization analysis. Methods Mol Med. 2002;68:45-57.
  • Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA. 2001;98:10983-5.
  • Carbone M, Setlak P, Bocchetta M, Rizzo P, Emri S, Baris YI, Pass HI, Testa JR, Dogan AU. Genetic susceptibility to mesotheliomA In: Peters, G.A, Peters, BJ. (eds.), Asbestos and Cancer, Sourcebook on Asbestos Diseases, Vol. 23, pp. 151-168. Charlottesville, VA: Lexis Law, Matthew Bender & Co, Inc, 2001.
  • Dogan AU, Baris YI, Emri S, Testa JR, Carbone M. Familial malignant mesothelioma - Reply. Lancet. 2001 Nov 24;358(9295):1813-4.
  • De Rienzo A, Balsara BR, Apostolou S, Jhanwar SC, Testa JR. Loss of heterozygosity analysis defines a 3-cM region of 15q commonly deleted in human malignant mesothelioma. Oncogene. 2001 Sep 27;20(43):6245-9.
  • Carbone M, Testa JR. Genetic susceptibility and familial malignant mesothelioma (authors' reply to Ascoli et al). Lancet 2001;357:1804.
  • Visconti PE, Hao Z, Purdon MA, Stein P, Balsara BR, Testa JR, Herr JC, Moss SB, Kopf GS. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. Genomics. 2001 Oct;77(3):163-70.
  • Gabrielson EW, Pinn ML, Testa JR, Kuhajda FP. Increased fatty acid synthase is a therapeutic target in mesothelioma. Clin Cancer Res. 2001 Jan;7(1):153-7.
  • Fujio Y, Mitsuuchi Y, Testa JR, Walsh K. Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation. Cell Death Differ. 2001 Dec;8(12):1207-12.
  • De Luca A, Tosolini A, Russo P, Severino A, Baldi A, De Luca L, Cavallotti I, Baldi F, Giordano A, Testa JR, Paggi MG. Cyclin T2A gene maps on human chromosome 2q21. J Histochem Cytochem. 2001;49:693-8.
  • Pei J, Balsara BR, Li W, Litwin S, Gabrielson E, Feder M, Jen J, Testa JR. Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas. Genes Chromosomes Cancer. 2001 Jul;31(3):282-7.
  • Balsara BR, Pei J, De Rienzo A, Simon D, Tosolini A, Lu YY, Shen F-M, Fan X, Lin WY, Buetow KH, London WT, Testa JR. Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1. Genes Chromosomes Cancer. 2001;30:245-53.
  • Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res. 2001 Jan 15;61(2):589-93.
  • Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):247-52.
  • Apostolou S, Murthy SS, Kolachana P, Jhanwar SC, Testa JR. Absence of post-transcriptional RNA modifications of BCL10 in human malignant mesothelioma and colorectal cancer. Genes Chromosomes Cancer. 2001;30:96-8.
  • Testa JR, Carbone M. MesotheliomA In: Schwab, M (ed.), In: Cancer Research: An Encyclopedic Reference, pp. 545-550. Heidelberg: Springer Verlag, 2001.
  • Testa JR, Giordano A. SV40 and cell cycle perturbations in malignant mesotheliomA Semin. Cancer Biol. 2001;11:31-8.
  • Testa JR, Pass HI, Carbone M. Molecular biology of mesotheliomA In: DeVita VT Jr, Hellman S, Rosenberg SA (eds.), Cancer: Principles and Practice of Oncology, 6th ed, pp. 1937-1943. Philadelphia: Lippincott, Williams & Wilkins 2001.
  • Roushdy-Hammady I, Siegel J, Emri S, Testa JR, Carbone M. Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey. Lancet. 2001;357:444-5.
  • Hopper E, Belinsky MG, Zeng H, Tosolini A, Testa JR, Kruh GD. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. Cancer Lett. 2001 Jan 26;162(2):181-91.
  • De Rienzo A, Testa JR. Recent advances in the molecular analysis of human malignant mesothelioma. Clin Ter. 2000 Nov-Dec;151(6):433-8.
  • Feder M, Liu Z, Apostolou S, Greenberg RE, Testa JR. Loss of chromosomes 1 and X in a renal oncocytoma: implications for a possible pseudoautosomal tumor suppressor locus. Cancer Genet Cytogenet. 2000 Nov;123(1):71-2.
  • Salicioni AM, Xi M, Vanderveer LA, Balsara B, Testa JR, Dunbrack RL, Godwin AK. Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. Genomics. 2000 Oct 1;69(1):54-62.
  • Bocchetta M, Di Resta I, Powers A, Fresco R, Tosolini A, Testa JR, Pass HI, Rizzo P, Carbone M. Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10214-9.
  • Mitsuuchi Y, Johnson SW, Selvakumaran M, Williams SJ, Hamilton TC, Testa JR. The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel. Cancer Res. 2000 Oct 1;60(19):5390-4.
  • Lee W-C, Testa JR. Techniques for identifying cancer genes. In: Kruh GD, Tew KD, editors. Basic Science of Cancer. Philadelphia: Current Medicine; 2000. p. 1-40.
  • Tosolini A, Testa JR. Genomic imbalances in lung cancer. In: Pass HI, Mitchell JB, Johnson DH, Turrisi AT, Minna JE, editors. Lung Cancer: Principles and Practice. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 502-17.
  • De Rienzo A, Jhanwar SC, Testa JR. Loss of heterozygosity analysis of 13q and 14q in human malignant mesothelioma. Genes Chromosomes Cancer. 2000 Jul;28(3):337-41.
  • Murthy SS, Tosolini A, Taguchi T, Testa JR. Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization. Cytogenet Cell Genet. 2000;88(1-2):38-40.
  • Murthy SS, Shen T, De Rienzo A, Lee WC, Ferriola PC, Jhanwar SC, Mossman BT, Filmus J, Testa JR. Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma. Oncogene. 2000 Jan 20;19(3):410-6.
  • Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. Am J Pathol. 2000 Apr;156(4):1253-61.
Top

1990 - 1999

  • Pass HI, Robinson BW, Testa JR, Carbone M. Emerging translational therapies for mesothelioma. Chest. 1999 Dec;116(6):455S-460S.
  • Morgan RO, Jenkins NA, Gilbert DJ, Copeland NG, Balsara BR, Testa JR, Fernandez MP. Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. Genomics. 1999 Aug 15;60(1):40-9.
  • Garay CA, Al-Saleem T, Testa JR, Smith MR. Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q). Leuk Res. 1999 Oct;23(10):965-7.
  • Kubo A, Nakagawa K, Varma RK, Conrad NK, Cheng JQ, Lee WC, Testa JR, Johnson BE, Kaye FJ, Kelley MJ. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 5: 4279-4286.
  • Riccio A, Aaltonen LA, Godwin AK, Loukola A, Percesepe A, Salovaara R, Masciullo V, Genuardi M, Paravatou-Petsotas M, Bassi DE, Ruggeri BA, Klein-Szanto AJ, Testa JR, Neri G, Bellacosa A. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet. 1999 Nov;23(3):266-8.
  • Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene. 1999;18:4891-8.
  • Apostolou S, De Rienzo A, Murthy SS, Jhanwar SC, Testa JR. Absence of BCL10 mutations in human malignant mesothelioma. Cell. 1999 Jun 11;97(6):684-6.
  • Jaiswal AK, Bell DW, Radjendirane V, Testa JR. Localization of human NQO1 gene to chromosome 16q22 and NQO2- 6p25 and associated polymorphisms. Pharmacogenetics. 1999 Jun;9(3):413-8.
  • Fujio Y, Guo K, Mano T, Mitsuuchi Y, Testa JR, Walsh K. Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol Cell Biol. 1999 Jul;19(7):5073-82.
  • Sonobe H, Takeuchi T, Liag SB, Taguchi T, Yuri K, Shimizu K, Iwata J, Furihata M, Ohtsuki Y, Testa JR. A new human synovial sarcoma cell line, HS-SY-3, with a truncated form of hybrid SYT/SSX1 gene. Int J Cancer. 1999 Jul 30;82(3):459-64.
  • Abdollahi A, Getts LA, Sonoda G, Miller PD, Taguchi T, Godwin AK, Testa JR, Hamilton TC. Genome scanning detects amplification of the cathepsin B gene (CtsB) in transformed rat ovarian surface epithelial cells. J Soc Gynecol Investig. 1999 Jan-Feb;6(1):32-40.
  • Murthy SS, Testa JR. Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma. J Cell Physiol. 1999 Aug;180(2):150-7.
  • Lee WC, Testa JR. Somatic genetic alterations in human malignant mesothelioma (Review). Int J Oncol. 1999 Jan;14(1):181-8.
  • Balsara BR, Bell DW, Sonoda G, De Rienzo A, du Manoir S, Jhanwar SC, Testa JR. Comparative genomic hybridization and loss of heterozygosity analyses identify a common region of deletion at 15q11.1-15 in human malignant mesothelioma. Cancer Res. 1999 Jan 15;59(2):450-4.
  • Morgan RO, Bell DW, Testa JR, Fernandez MP. Human annexin 31 genetic mapping and origin. Gene. 1999 Feb 4;227(1):33-8.
  • Cheng JQ, Lee WC, Klein MA, Cheng GZ, Jhanwar SC, Testa JR. Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: Evidence for a two-hit mechanism of NF2 inactivation. Genes Chromosomes & Cancer. 1999 Mar;24(3):238-42.
  • Rodriguez-Alfageme C, Chen Z, Sonoda G, Testa JR, Damiani RD, Astrin SM. B cells malignantly transformed by human immunodeficiency virus are polyclonal. Virology. 1998 Dec 5;252(1):34-8.
  • Testa, JR, Carbone, M, Hirvonen, A, Khalili, K, Krynska, B, Linnainmaa, K, Pooley, FD, Rizzo, P, Rusch, V, Xiao, GH. A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas. Cancer Res 1998 58: 4505-4509.
  • Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JQ. AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res. 1998 Jul 15;58(14):2973-7.
  • Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. J Natl Cancer Inst. 1998 Nov 18;90(22):1735-41.
  • Schultz DC, Balasara BR, Testa JR, Godwin AK. Cloning and localization of a human diphthamide biosynthesis- like protein-2 gene, DPH2L2. Genomics. 1998 Sep 1;52(2):186-91.
  • Mitsuuchi Y, Johnson SW, Moonblatt S, Testa JR. Translocation and activation of AKT2 in response to stimulation by insulin. J Cell Biochem. 1998 Sep 15;70(4):433-41.
  • Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD. Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein canalicular multispecific organic anion transporter-related transporter. Cancer Res. 1998 Jul 1;58(13):2741-7.
  • Gonzalez AD, Kaya M, Shi W, Song H, Testa JR, Penn LZ, Filmus J. OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth Syndrome, induces apoptosis in a cell line-specific manner. J Cell Biol. 1998 Jun 15;141(6):1407-14.
  • Randhawa GS, Bell DW, Testa JR, Feinberg AP. Identification and mapping of human histone acetylation modifier gene homologues. Genomics. 1998 Jul 15;51(2):262-9.
  • Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene. 1998;16:2407-11.
  • Laing NM, Belinsky MG, Kruh GD, Bell DW, Boyd JT, Barone L, Testa JR, Tew KD. Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells. Cancer Res. 1998;58:1332-7.
  • Feder M, Siegfried JM, Balshem A, Litwin S, Keller SM, Liu Z, Testa JR. Clinical relevance of chromosome abnormalities in non-small cell lung cancer. Cancer Genet Cytogenet. 1998;102:25-31.
  • Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog. 1998;21:81-6.
  • Khazak V, Estojak J, Cho H, Majors J, Sonoda G, Testa JR, Golemis EA. Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II. Mol Cell Biol. 1998;18: 1935-45.
  • Morgan RO, Bell DW, Testa JR, Fernandez MP. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. Genomics. 1998;48:100-10.
  • Testa JR, Bellacosa A. Membrane translocation and activation of the Akt kinase in growth factor-stimulated hematopoietic cells. (Commentary). Leukemia Res. 1997;21:1027-31.
  • Siegfried JM, Gillespie AT, Mera R, Casey TJ, Keohavong P, Testa JR, Hunt JD. Prognostic value of specific KRAS mutations in lung adenocarcinomas. Cancer Epidemiology Biomarkers & Prevention. 1997 Oct;6(10):841-7.
  • Bell DW, Jhanwar SC, Testa JR. Multiple regions of allelic loss from chromosome arm 6q in malignant mesothelioma. Cancer Res. 1997 Sep 15;57(18):4057-62.
  • Serebriiskii I, Estojak J, Sonoda G, Testa JR, Golemis EA. Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22. Oncogene. 1997 Aug 28;15(9):1043-9.
  • Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA. Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice. Hum Mol Genet. 1997 Aug;6(8):1225-31.
  • Keohavong P, Zhu D, Melacrinos AC, DeMichele AA, Weyant RJ, Luketich JD, Testa JR, Fedder M, Siegfried JM. Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method. Int J Cancer. 1997 Apr 22;74(2):162-70.
  • Taguchi T, Cheng GZ, Bell DW, Balsara B, Liu Z, Siegfried JM, Testa JR. Combined chromosome microdissection and comparative genomic hybridization detect multiple sites of amplification DNA in a human lung carcinoma cell line. Genes Chromosomes Cancer. 1997 Oct;20(2):208-12.
  • Sonoda G, Palazzo J, du Manoir S, Godwin AK, Feder M, Yakushiji M, Testa JR. Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas. Genes Chromosomes Cancer. 1997 Dec;20(4):320-8.
  • Cheng JQ, Altomare DA, Klein MA, Lee WC, Kruh GD, Lissy NA, Testa JR. Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene. 1997 Jun 12;14(23):2793-801.
  • Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE. The cloning and characterization of human MyD88: A member of an IL-1 receptor related family. FEBS Lett. 1997 Jan 27;402(1):81-4.
  • Balsara BR, Sonoda G, duManoir S, Siegfried JM, Gabrielson E, Testa JR. Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas. Cancer Res. 1997 Jun 1;57(11):2116-20.
  • Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells. Cancer Res. 1997 May 15;57(10):2029-34.
  • Siegfried JM, Weissfeld LA, SinghKaw P, Weyant RJ, Testa JR, Landreneau RJ. Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer. Cancer Res. 1997 Feb 1;57(3):433-9.
  • Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC. Identification of a zinc-finger gene at 6q25: A chromosomal region implicated in development of many solid tumors. Oncogene. 1997 Apr 24;14(16):1973-9.
  • Sonoda G, du Manoir S, Godwin AK, Bell DW, Liu Z, Hogan M, Yakushiji M, Testa JR. Detection of DNA gains and losses in primary endometrial carcinomas by comparative genomic hybridization. Genes Chromosomes Cancer. 1997 Feb;18(2):115-25.
  • Testa JR, Liu Z, Feder M, Bell DW, Balsara B, Cheng JQ, Taguchi T. Advances in the analysis of chromosome alterations in human lung carcinomas. Cancer Genet Cytogenet. 1997 May;95(1):20-32.
  • Bell DW, Testa JR. Tumor suppressor genes in malignant mesothelioma. In: Peters, G.A, Peters, B.J. (eds.), Asbestos and Cancer, Sourcebook on Asbestos Diseases, Vol. 16, pp. 99-126. Charlottesville, VA: LEXIS Law, 1997.
  • Suzuki E, Evans T, Lowry J, Truong L, Bell DW, Testa JR, Walsh K. The human GATA-6 gene: Structure, chromosomal location, and regulation of expression by tissue-specific and mitogen- responsive signals. Genomics. 1996 Dec 15;38(3):283-90.
  • Shen T, Sonoda G, Hamid J, Li M, Filmus J, Buick RN, Testa JR. Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to Chromosome X in human and rat by fluorescence in situ hybridization. Mamm Genome. 1997 Jan;8(1):72.
  • Altomare DA, Kozak CA, Sonoda G, and Testa JR. Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene. Cytogenet Cell Genet. 1996;74:248-51.
  • Wang ZY, Qiu QQ, Seufert W, Taguchi T, Testa JR, Whitmore A, Callen DF, Welsh D, Shenk T, Deuel TF. Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J Biol Chem. 1996 Oct 4;271(40):24811-6.
  • Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE. Cloning of a putative ligand for the T1/ST2 receptor. J Biol Chem. 1996;271:5784-9.
  • Lee WC, Balsara B, Liu Z, Jhanwar SC, Testa JR. Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma. Cancer Res. 1996;56:4297-430.
  • Noben-Trauth K, Copeland NG, Gilbert DJ, Jenkins NA, Sonoda G, Testa JR, Klempnauer KH. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q13.1. Genomics. 1996;35:610-2.
  • Mann EA, Swenson ES, Copeland NG, Gilbert DJ, Jenkins NA, Taguchi T, Testa JR, Giannella RA. Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12. Genomics. 1996;34:265-7.
  • Johnson SW, Lissy NA, Miller PD, Testa JR, Ozols RF, Hamilton TC. Identification of zinc finger mRNAs using domain-specific differential display. Anal Biochem. 1996;236:348-52.
  • Yeung RS, Buetow KH, Scherpbier-Heddema T, Bell DW, Testa JR. A genetic, physical, and comparative map of rat Chromosome 10. Mamm. Genome 1996;7:425-8.
  • Wang BL, Mysliwiec T, Krainc D, Jensen RA, Sonoda G, Testa JR, Golemis EA, Kruh GD. Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. Oncogene. 1996 May 2;12(9):1921-9.
  • Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA. 1996;93:3636-41.
  • Yeung RS, Bell DW, Testa JR. The Vpreb1 and Comt genes are closely linked and sublocalized to rat chromosome 11q23. Mamm Genome. 1996 Mar;7(3):246-7.
  • Taguchi T, Mitcham JL, Dower SK, Sims JE, Testa JR. Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor toll, to human chromosome 4p14. Genomics. 1996 Mar 15;32(3):486-8.
  • Taguchi T, Zhou JY, Feder M, Litwin S, KleinSzanto AJ, Testa JR. Detection of aneuploidy in interphase nuclei from non-small cell lung carcinomas by fluorescence in situ hybridization using chromosome-specific repetitive DNA probes. Cancer Genet Cytogenet. 1996 Jul 15;89(2):120-5.
  • Lissy NA, Bellacosa A, Sonoda G, Miller PD, Jhanwar SC, Testa JR. Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC. Biochim Biophys Acta. 1996 May 2;1306(2-3):137-41.
  • Suzuki E, Lowry J, Sonoda G, Testa JR, Walsh K. Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP. Cytogenet. Cell Genet. 1996;73:244-9.
  • Testa JR. Chromosome alterations in human lung cancer. In: Pass, H.I, Mitchell, J.B, Johnson, D.H, Turrisi, A.T. (eds.), Lung Cancer: Principles and Practice, pp. 55-71. Philadelphia: Lippincott-Raven, 1996.
  • Bianchi AB, Mitsunaga SI, Cheng JQ, Klein WM, Jhanwar SC, Seizinger B, Kley N, Kleinszanto AJ, Testa JR. High-Frequency of Inactivating Mutations in the Neurofibromatosis Type-2 Gene (Nf2) in Primary Malignant Mesotheliomas. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10854-8.
  • Godwin AK, Miller PD, Getts LA, Jackson K, Sonoda G, Schray KJ, Testa JR, Hamilton TC. Retroviral-Like Sequences Specifically Expressed in the Rat Ovary Detect Genetic-Differences between Normal and Transformed Rat Ovarian Surface Epithelial-Cells. Endocrinology. 1995 Oct;136(10):4640-9./li>
  • Altomare DA, Guo K, Cheng JQ, Sonoda G, Walsh K, Testa JR. Cloning, Chromosomal Localization and Expression Analysis of the Mouse Akt2 Oncogene. Oncogene. 1995 Sep 21;11(6):1055-60.
  • Bellacosa A, Defeo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan MH, Dubeau L, Scambia G, Masciullo V, Ferrandina G, Panici PB, Mancuso S, Neri G, Testa JR. MOLECULAR ALTERATIONS OF THE AKT2 ONCOGENE IN OVARIAN AND BREAST CARCINOMAS. Int J Cancer. 1995 Aug;64(4):280-5.
  • Bell DW, Yeung RS, Bohlander SK, Cheng JQ, Jin F, Testa JR. A Microdissection Library of the Rat Renal-Carcinoma Gene Region. Cytogenet Cell Genet. 1995;70(1-2):92-4.
  • Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidlermckay P, Grimes HL, Tsichlis PN, Testa JR. Chromosomal Localization of a Gene, Gfi1, Encoding a Novel Zinc-Finger Protein Reveals a New Syntenic Region between Man and Rodents. Cytogenet Cell Genet. 1995;70(3-4):263-7.
  • Sciaky D, Jenkins NA, Gilbert DJ, Copeland NG, Sonoda G, Testa JR, Cohen MB. Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35. Genomics. 1995;26:427-9.
  • Marlton P, Claxton DF, Liu P, Estey EH, Beran M, LeBeau M, Testa JR, Collins FS, Rowley JD, Siciliano, M.J. Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis. Blood 1995;85:772-9.
  • Salazar H, Godwin AK, Getts LA, Testa JR, Daly M, Rosenblum N, Hogan M, Ozols RF, Hamilton TC. Spontaneous transformation of the ovarian surface epithelium and the biology of ovarian cancer. In: Sharp F, Mason P, Blackett T, Berek J. (eds), Ovarian Cancer 3, pp. 145-156. London: Chapman & Hall Medical, 1995.
  • Moore KJ, Testa JR, Franke U, Milatovich A, Copeland NG, Jenkins NA. Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome 15q21. Cytogenet. Cell Genet. 1995;69:53-8.
  • Yeung RS, Xiao GH, Jin F, Lee WC, Testa JR, Knudson AG. Predisposition to Renal-Carcinoma in the Eker Rat Is Determined by Germ-Line Mutation of the Tuberous-Sclerosis-2 (Tsc2) Gene. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11413-6.
  • LePage DF, Altomare DA, Testa JR, Walsh K. Molecular cloning and localization of the human GAX gene to 7p21. Genomics 1994;24:535-40.
  • Cheng JQ, Jhanwar SC, Klein WM, Bell DW, Lee WC, Altomare DA, Nobori T, Olopade OI, Buckler AJ, Testa JR. P16 Alterations and Deletion Mapping of 9p21-P22 in Malignant Mesothelioma. Cancer Res. 1994 Nov 1;54(21):5547-51.
  • Testa JR, Zhou JY, Bell DW, Yen TJ. Chromosomal Localization of the Genes Encoding the Kinetochore Proteins Cenpe and Cenpf to Human-Chromosomes 4q24- Q25 and 1q32- Q41 Respectively, by Fluorescence in-Situ Hybridization. Genomics. 1994 Oct;23(3):691-3.
  • Testa JR, Siegfried JM, Liu ZM, Hunt JD, Feder MM, Litwin S, Zhou JY, Taguchi T, Keller SM. Cytogenetic Analysis of 63 Nonsmall Cell Lung Carcinomas - Recurrent Chromosome Alterations Amid Frequent and Widespread Genomic Upheaval. Genes Chromosomes & Cancer. 1994 Nov;11(3):178-94.
  • Testa JR, Getts LA, Salazar H, Liu ZM, Handel LM, Godwin AK, Hamilton TC. Spontaneous Transformation of Rat Ovarian Surface Epithelial- Cells Results in Well to Poorly Differentiated Tumors with a Parallel Range of Cytogenetic Complexity. Cancer Res. 1994 May 15;54(10):2778-84.
  • Taguchi T, Testa JR, Papas TS, Schweinfest C. Localization of a Candidate Colon Tumor-Suppressor Gene (Dra) to 7q22-Q31.1 by Fluorescence in-Situ Hybridization. Genomics. 1994 Mar 1;20(1):146-7.
  • Lu YY, Jhanwar SC, Cheng JQ, Testa JR. Deletion Mapping of the Short Arm of Chromosome-3 in Human- Malignant Mesothelioma. Genes Chromosomes & Cancer. 1994 Jan;9(1):76-80.
  • Siegfried JM, Davis AL, Testa JR, Hunt JD, Keenan RJ, Yousem SA, Ritter PS, Ferson PF, Landreneau RJ. Ability to Culture Resectable Nonsmall Cell Lung Carcinomas Is Correlated with Recurrence. Ann Thorac Surg. 1994 Sep;58(3):662-7.
  • Yeung RS, Buetow KH, Testa JR, Knudson AG Jr. Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10. Proc Natl Acad Sci USA. 1993;90:8038-42.
  • Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Grana X, Klinga-Levan K, Knudson AG, Giordano A. The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene 1993;8:3465-8.
  • Cheng JQ, Jhanwar SC, Lu YY, Testa JR. Homozygous Deletions within 9p21-P22 Identify a Small Critical Region of Chromosomal Loss in Human-Malignant Mesotheliomas. Cancer Res. 1993 Oct 15;53(20):4761-3.
  • Taguchi T, Jhanwar SC, Siegfried JM, Keller SM, Testa JR. Recurrent Deletions of Specific Chromosomal Sites in 1p, 3p, 6q, and 9p in Human-Malignant Mesothelioma. Cancer Res. 1993 Sep 15;53(18):4349-55.
  • Hino O, Testa JR, Buetow KH, Taguchi T, Zhou JY, Bremer M, Bruzel A, Yeung R, Levan G, Levan KK, Knudson AG, Tartof KD. Universal Mapping Probes and the Origin of Human Chromosome-3. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):730-4.
  • Wang ND, Testa JR, Smith DI. Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. Genomics. 1993;17:341-7.
  • Ozer H, George SL, Schiffer CA, Rao K, Rao PN, Wurster-Hill DH, Arthur DA, Powell B, Gottlieb A, Peterson BA, Rai K, Testa JR, LeBeau M, Tantravahi R, Bloomfield CD. Prolonged subcutaneous administration of recombinant α2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival. Cancer and Leukemia Group B study 8583. Blood. 1993;82:2975-84.
  • Hino O, Klein-Szanto AJ, Freed JJ, Testa JR, Brown DQ, Vilensky M, Yeung RS, Tartof KD, Knudson AG. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci USA. 1993;90:327-31.
  • Taguchi T, Bellacosa A, Zhou JY, Gilbert DJ, Lazo PA, Copeland NG, Jenkins NA, Tsichlis PN, Testa JR. Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents. Cytogenet Cell Genet. 1993;64(3-4):217-21.
  • Garcia de Palazzo IE, Adams GP, Sundareshan P, Wong AJ, Testa JR, Bigner DD, Weiner LM. Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. Cancer Res. 1993;53:3217-20.
  • Ahmed NN, Franke TF, Bellacosa A, Datta K, Gonzalez-Portal ME, Taguchi T, Testa JR, Tsichlis PN. The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene. 1993 Jul;8(7):1957-63.
  • Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. 1993 Mar;8(3):745-54.
  • Bellacosa A, Testa JR, Tsichlis PN. Identification of the AKT oncogene. Acta Medica Romana. 1993;31:297-314.
  • Zhou JY, Taguchi T, Siegfried JM, Jhanwar SC, Resau J, Testa JR. Characterization of 9q;15q whole-arm translocation derivatives in non- small cell lung carcinomas by fluorescence in situ hybridization. Cancer Genet Cytogenet. 1993;69(1):1-6.
  • Testa JR, Graziano SL. Molecular Implications of Recurrent Cytogenetic Alterations in Human Small-Cell Lung-Cancer. Cancer Detect Prev. 1993;17(2):267-77.
  • Siegfried JM, Hunt JD, Zhou JY, Keller SM, Testa JR. Cytogenetic abnormalities in non-small cell lung carcinoma: similarity of findings in conventional and feeder cell layer cultures. Genes Chromosomes Cancer. 1993;6:30-8.
  • Yeung RS, Taguchi T, Patriotis C, Makris A, Tsichlis PN, Levan KK, Levan G, Tartof K, Hino O, Knudson AG, Testa JR. New markers, D16FC1 and Tpl2, differentiate between rat chromosomes 16 and 17. Cytogenet Cell Genet. 1993;62(2-3):149-52.
  • Godwin AK, Testa JR, Hamilton TC. The biology of ovarian cancer development. Cancer 71 (2 Suppl.): 1993;530-6.
  • Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9267-71.
  • Wang ND, Testa JR, Smith DI. Localization of 3 Novel Hybrid Breakpoints and Refinement of 18 Marker Assignments in the Human 3cen-P21.1 Region. Genomics. 1992 Dec;14(4):891-6.
  • Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS, Seth A. The Ergb Fli-1 Gene - Isolation and Characterization of a New Member of the Family of Human Ets Transcription Factors. Cell Growth Differ. 1992 Oct;3(10):705-13.
  • Testa JR, Taguchi T, Knudson AG, Hino O. Localization of the Interferon-Alpha Gene-Cluster to Rat Chromosome Bands 5q31- Q33 by Fluorescence Insitu Hybridization. Cytogenet Cell Genet. 1992;60(3-4):247-9.
  • Miura I, Graziano SL, Cheng JQ, Doyle LA, Testa JR. Chromosome Alterations in Human Small-Cell Lung-Cancer - Frequent Involvement of 5q. Cancer Res. 1992 Mar 1;52(5):1322-8.
  • Testa JR, Siegfried JM. Chromosome abnormalities in human non-small cell lung cancer. Cancer Res. 1992 May 1;52(9 SUPPL.):2702s-2706s.
  • Garcia-Palazzo IE, Palazzo JP, Ze Min L, Taguchi T, Testa JR. Cytogenetic findings in a breast stromal sarcoma: Application of fluorescence in situ hybridization to characterize the breakpoint regions in an 11:19 translocation. Cancer Genet Cytogenet. 1992;63(1):47-51.
  • Godwin AK, Testa JR, Handel LM, Liu Z, Vanderveer LA, Tracey PA, Hamilton TC. Spontaneous Transformation of Rat Ovarian Surface Epithelial- Cells - Association with Cytogenetic Changes and Implications of Repeated Ovulation in the Etiology of Ovarian-Cancer. J Natl Cancer Inst. 1992 Apr 15;84(8):592-601.
  • Testa JR, Siegfried JM. Recurrent chromosome abnormalities in non-small cell lung carcinoma. Lung Cancer Res Quarterly 1992;2:15-22.
  • Lee EJ, Yang J, Leavitt RD, Testa JR, Civin CI, Forrest A, Schiffer CA. The significance of CD34 and TdT determinations in patients with untreated de novo acute myeloid leukemia. Leukemia. 1992;6:1203-9.
  • Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science. 1991 Oct 11;254(5029):274-7.
  • Lehman TA, Bennett WP, Metcalf RA, Welsh JA, Ecker J, Modali RV, Ullrich S, Romano JW, Appella E, Testa JR, Gerwin BI, Harris CC. P53 Mutations, Ras Mutations, and P53-Heat Shock 70 Protein Complexes in Human Lung-Carcinoma Cell-Lines. Cancer Res. 1991 Aug 1;51(15):4090-6.
  • Bellacosa A, Testa JR, Tsichlis PN. Oncogene File: AKT. Cancer Cells. 1991;3:535.
  • Siegfried JM, Ellison DJ, Resau JH, Miura I, Testa JR. Correlation of modal chromosome number of cultured non-small cell lung carcinomas with DNA index of solid tumor tissue. Cancer Res. 1991;51:3267-73.
  • Graziano SL, Pfeifer AM, Testa JR, Mark GE, Johnson BE, Hallinan EJ, Pettengill OS, Sorenson GD, Tatum AH, Brauch H, Zbar B, Flejter WL, Ehrlich GD, Poiesz BJ. Involvement of the RAF1 locus, at band 3p25, in the 3p deletion of small-cell lung cancer. Genes Chromosomes Cancer 1991;3:283-93.
  • Resau JH, Albright CD, Cottrell JR, Colombo-Burke KL, Aisner SC, Miura I, Testa JR. Exfoliative cytologic evaluation of primary cultured lung carcinomas. Cytotechnol. 1991;6:143-52.
  • Hallman D, Testa JR. Cytogenetics of acute leukemia. In: Wiernik PH, Canellos GP, Kyle RA, Schiffer CA, (eds.), Neoplastic Diseases of the Blood, 2nd ed, pp. 215-229. New York: Churchill Livingstone, 1991.
  • Siegfried JM, Resau J, Miura I, Testa JR. Primary culture of solid lung tumors for chromosomal analysis. In: Adolph, KW. (ed.), Advanced Techniques in Chromosome Research, pp. 411-425. New York: Marcel Dekker, 1991.
  • Testa JR. Genetics and cancer -- an overview. In: Moossa, A.R, Schimpff, S.C, and Robson, M.C. (eds.), Comprehensive Textbook of Oncology. 2nd ed, pp. 81-83. Baltimore: Williams & Wilkins, 1991.
  • Hallman D, Testa JR. Chromosomal abnormalities associated with human malignancies. In: Moossa AR, Schimpff SC, Robson MC. (eds), Comprehensive Textbook of Oncology, 2nd ed, pp. 84-91. Baltimore: Williams & Wilkins, 1991.
  • Miura I, Siegfried JM, Resau J, Keller SM, Zhou JY, Testa JR. Chromosome alterations in 21 non-small cell lung carcinomas. Genes Chromosomes Cancer 1990;2:328-38.
  • Testa JR. Chromosome translocations in human cancer. Cell Growth Differ. 1990;1:97-101.
  • Morris C, Heisterkamp N, Hao QL, Testa JR, Groffen J. The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Cytogenet. Cell Genet. 1990;53:196-200.
  • Dohner H, Arthur DC, Ball ED, Sobol RE, Davey FR, Lawrence D, Gordon L, Patil SR, Surana RB, Testa JR, Verma RS, Schiffer CA, Wurster-Hill DH, Bloomfield CD. Trisomy 13: a new recurring chromosome abnormality in acute leukemia. Blood. 1990;76:1614-21.
  • Testa JR, Park M, Blair DG, Kalbakji A, Arden K, Vande Woude GF. Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS. Oncogene. 1990;5:1565-71.
  • Vande Woude GF, Gonzatti-Haces M, Iyer A, Park M, Testa JR, Oskarsson M, Paules RS, Propst F, Sagata N. The mos and met oncogenes: transformation and reverse genetics. In: Frei E. III (ed.), The Regulation of Proliferation and Differentiation in Normal and Neoplastic Cells, pp. 143-164. New York: Academic Press, 1990.
  • Miura I, Resau J, Tomiyasu T, Testa JR. Isochromosome (8q) in four patients with adenocarcinoma of the lung. Cancer Genet Cytogenet. 1990;48:203-7.
  • Lee EJ, Schiffer CA, Tomiyasu T, Testa JR. Clinical and cytogenetic correlations of abnormal megakaryocytopoiesis in patients with acute leukemia and chronic myelogenous leukemia in blast crisis. Leukemia. 1990;4:350-3.
  • Bloomfield CD, Wurster-Hill D, Peng G, Le Beau M, Tantravahi R, Testa J, Davey FR, Ellison RR, Cuttner J, Schiffer C, Sobol RE, Lunghofer B, Carey M, Mick R, Arthur D. Prognostic significance of the Philadelphia chromosome in adult acute lymphoblastic leukemia. In: Gale RP, Hoelzer D. (eds), Acute Leukemia, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 108, pp. 101-109. New York: Alan R. Liss, Inc, 1990.
  • Needleman SW, Mane SM, Gutheil JC, Kapil V, Heyman MR, Testa JR. Hypereosinophilic syndrome with evolution to myeloproliferative disorder: temporal relationship to loss of Y chromosome and c-N-ras activation. Hematol. Pathol. 1990;4:149-55.
  • Flejter WL, Li FP, Antman KH, Testa JR. Recurring loss involving chromosomes 1, 3 and 22 in malignant mesothelioma: possible sites of tumor suppressor genes. Genes Chromosomes Cancer 1: 148-154, 1989.mporal relationship to loss of Y chromosome and c-N-ras activation. Hematol Pathol. 1990;4:149-55.
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1980 - 1989

  • Tanaka K, Boice CR, Testa JR. Chromosome aberrations in nine patients with ovarian cancer. Cancer Genet Cytogenet. 1989;43:1-14.
  • Mules EH, Testa JR, Thomas GH, Abbey H, Cohen BH. Cancer in relatives of leukemic patients with chromosomal rearrangements at rare (heritable) fragile-site locations in their malignant cells. Am J Hum Genet. 1989;44:811-9.
  • Heisterkamp N, Jenkins R, Thibodeau S, Testa JR, Weinberg K, Groffen J. The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia. Blood. 1989;73:1307-11.
  • Schiffer CA, Lee EJ, Tomiyasu T, Wiernik PH, Testa JR. Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia. Blood. 1989;73:263-70.
  • Park M, Testa JR, Blair DG, Parsa NZ, Vande Woude GF. Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus. Proc Natl Acad Sci USA. 1988;85:2667-71.
  • Testa JR, Parsa NZ, Le Beau MM, Vande Woude GF. Localization of the proto-oncogene MOS to 8q11-q12 by in situ chromosomal hybridization. Genomics. 1988;3:44-7.
  • Staal SP, Huebner K, Croce CM, Parsa NZ, Testa JR. The AKT1 proto-oncogene maps to human chromosome 14, band q32. Genomics. 1988;2:96-8.
  • Fischkoff SA, Testa JR, Schiffer CA. Acute eosinophilic leukemia with a (10;11) chromosomal translocation. Leukemia. 1988;2:3947.
  • Tomiyasu T, Testa JR. Application of ethidium bromide for high-resolution banding analysis of chromosomes from human malignant cells. Stain Technol. 1988;63:83-91.
  • Ross DD, Ordonez JV, Joneckis CC, Testa JR, Thompson BW. Isolation of highly multidrug-resistant P388 cells from drug-sensitive P388/S cells by flow cytometric cell sorting. Cytometry 1988;9:359-67.
  • Tanaka K, Testa JR. Assessment of methods for the cytogenetic analysis of human solid tumors. J Natl Cancer Inst. 1987;79:1287-93.
  • Lee EJ, Pollak A, Leavitt RD, Testa JR, Schiffer CA. Minimally differentiated acute nonlymphocytic leukemia: a distinct entity. Blood. 1987;70:1400-6.
  • Helenglass G, Testa JR, Schiffer CA. Philadelphia chromosome-positive acute leukemia: morphologic and clinical correlations. Am J Hematol. 1987;25:311-24.
  • Misawa S, Staal SP, Testa JR. Amplification of the c-myc oncogene is associated with an abnormally banded region on chromosome 8 or double minute chromosomes in two HL-60 human leukemia sublines. Cancer Genet Cytogenet. 1987;28:127-35.
  • Tanaka K, Baylin SB, Nelkin BD, Testa JR. Cytogenetic studies of a human medullary thyroid carcinoma cell line. Cancer Genet Cytogenet. 1987;25:27-35.
  • Lee EJ, Schiffer CA, Misawa S, Testa JR. Clinical and cytogenetic features of familial erythroleukemia. Brit J Haematol. 1987;65:313-20.
  • Park M, Gonzatti-Haces M, Dean M, Blair DG, Testa JR, Bennett DD, Copeland T, Oroszlan S, Vande Woude G. The met oncogene: a new member of the tyrosine kinase family and a marker for cystic fibrosis. Cold Spring Harbor Symp Quant Biol 51 Pt. 1986;2:967-75.
  • Testa JR. Cytogenetics and human neoplasia. In: Moossa AR, Robson MC, Schimpff SC. (eds.), Comprehensive Textbook of Oncology, pp. 28-35. Baltimore: Williams & Wilkins, 1986.
  • Misawa S, Abe T, Takamatsu T, Fujita S, Testa JR. Determination of chromosomal area of double minute chromosomes and a homogeneously staining region in HL-60 human leukemia cells by the use of a color image analyzer. Jinrui Idengaku Zasshi (Jpn J Hum Genet). 1986;31:297-307.
  • Testa JR, Misawa S, Pollak A, Leavitt R. Unusual cytogenetic findings in two patients with t(4;11) acute leukemia. Int J Cancer. 1986;38:847-52.
  • Barker PE, Testa JR, Parsa NZ, Snyder R. High molecular weight DNA from fixed cytogenetic preparations. Am J Hum Genet. 1986;39:661-8.
  • Misawa S, Hogge DE, Oguma N. Wiernik PH, Testa JR. Detection of clonal karyotypic abnormalities in most patients with acute nonlymphocytic leukemia examined using short-term culture techniques. Cancer Genet Cytogenet. 1986;22:239-51.
  • Testa JR, Cohen BC. Dicentric chromosome 17 in patients with leukemia. Cancer Genet Cytogenet. 1986;23:47-52.
  • Misawa S, Lee E, Schiffer CA, Liu Z, Testa JR. Association of the translocation (15;17) with malignant proliferation of promyelocytes in acute leukemia and chronic myelogenous leukemia at blastic crisis. Blood. 1986;67:270-4.
  • Testa JR, Misawa S. Chromosome changes in leukemia. In: Chaganti RSK, German JL. (eds), Genetics in Clinical Oncology, pp. 159-184. Oxford: Oxford University Press, 1985.
  • Testa JR, Arthur DC. Cytogenetics of leukemia and lymphoma. In: Wiernik PH. (ed), Contemporary Issues in Clinical Oncology: Leukemias and Lymphomas. Vol. 4, pp. 155-182. New York: Churchill Livingstone, 1985.
  • Testa JR. Cytogenetics of acute leukemia. In: Wiernik PH, Canellos GP, Kyle RA, Schiffer CA. (eds), Neoplastic Diseases of the Blood, Vol. 1, pp. 249-265. New York: Churchill Livingstone, 1985.
  • Mukherjee AB, Czirbik RJ, Parsa NZ, Testa JR. Induction of terminal differentiation and nuclear appendage(s) formation in a human myeloid leukaemia cell line (HL-60). Cytobios 1985;44:109-18.
  • Oguma N, Kamada N, Kuramoto A, Tanaka K, Misawa S, Testa JR. Double minute chromosomes in acute myeloblastic leukemia. J Natl Cancer Inst. 1985;74:1007-13.
  • Misawa S, Oguma N, Testa JR. A case of acute lymphoblastic leukemia with severe hypodiploidy. Cancer Genet Cytogenet. 1985;16:137-43.
  • Mukherjee AB, Czirbik RJ, Hogge DE, Murtha MF, Testa JR. Fluorescent bodies in lymphocytes in chronic lymphocytic leukemia. Cancer Genet Cytogenet. 1985;15:227-36.
  • Testa JR, Misawa S, Oguma N, Van Sloten K, Wiernik PH. Chromosomal alterations in acute leukemia patients studied with improved culture methods. Cancer Res. 1985;45:430-4.
  • Miller JB, Testa JR, Lindgren V, Rowley JD. The pattern and clinical significance of karyotypic abnormalities in patients with idiopathic and postpolycythemic myelofibrosis. Cancer. 1985;55:582-91.
  • Testa JR. 'High-resolution' chromosomal analysis of acute leukaemia: current assessment. Cancer Surveys. 1984;3:359-69.
  • Hogge DE, Misawa S, Schiffer CA, Testa JR. Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation. Leuk Res. 1984;8:1019-23.
  • Misawa S, Testa JR, Strauss LC, Leavitt RD, Civin CI. Acquired chromosome rearrangements, including fine interstitial deletions, in a patient with Down syndrome and monoblastic leukemia. Pediatrics. 1984;74:1029-33.
  • Rapoza PA, Testa JR, Eques MC, Rowley JD. Evaluation of techniques for increasing mitotic yield and chromosome length in leukemic cells. Acta Cytol. 1984;28:740-6.
  • Przepiorka D, Baylin SB, McBride OW, Testa JR, de Bustros A, Nelkin BD. The human calcitonin gene is located on the short arm of chromosome 11. Biochem Biophys Res Commun. 1984;120:493-9.
  • Fischkoff SA, Pollak A, Gleich GJ, Testa JR, Misawa S, Reber TJ. Eosinophilic differentiation of the human promyelocytic leukemia cell line, HL-60. J Exptl Med. 1984;160:179-96.
  • Hogge DE, Misawa S, Parsa NZ, Pollak A, Testa JR. Abnormalities of chromosome 16 in association with acute myelomonocytic leukemia and dysplastic bone marrow eosinophils. J Clin Oncol. 1984;2:550-7.
  • Gallagher RE, Ferrari AC, Zulich AW, Yen RW, Testa JR. Cytotoxic and cytodifferentiative components of 6-thioguanine-resistance in HL-60 cells containing acquired double minute chromosomes. Cancer Res 1984;44:2642-53.
  • Testa JR, Hogge DE, Misawa S, Zandparsa N. Chromosome 16 rearrangements in acute myelomonocytic leukemia with abnormal eosinophils. N Engl J Med. 1984;310:468-9.
  • Gallo JH, Ordonez JV, Brown GE, Testa JR. Synchronization of human leukemic cells: relevance for high-resolution chromosome banding. Hum Genet. 1984;66:220-4.
  • Gallo JH, Misawa S, Testa JR. Centromere spreading in acute nonlymphocytic leukemia. Cancer Genet Cytogenet. 1984;12:105-9.
  • Misawa S, Testa JR. Cytogenetic abnormalities in patients with acute leukemia studied with banding techniques, including the high-resolution banding method. In: Crispen RG. (ed), Cancer: Etiology and Prevention, pp. 29-42. New York: Elsevier Science, 1983.
  • Hogge DE, Misawa S, Testa JR, Leavitt RD, Pollak A, Schiffer CA. Unusual karyotypic changes and B cell involvement in a case of lymph node blast crisis of chronic myelogenous leukemia. Blood. 1984;64:123-30.
  • Oguma N, Misawa S, Testa JR. A variant 8;21 translocation in acute myeloblastic leukemia. Am J Hematol. 1983;15:391-6.
  • Testa JR, Oguma N, Misawa S, Wiernik PH. Chromosome abnormalities in acute leukemia: a higher incidence than previously assumed. Cancer Genet Cytogenet. 1983;9:305-6.
  • Larson RA, Le Beau MM, Vardiman JW, Testa JR, Golomb HM, Rowley JD. The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia: a 12-year study (1970-1983). Cancer Genet Cytogenet. 1983;10:219-36.
  • Dimery IW, Ross DD, Testa JR, Gupta SK, Felsted RL, Pollak A, Bachur NR. Variation amongst K562 cell cultures. Exptl Hematol. 1983;11:601-10.
  • Testa JR, Oguma N, Pollak A, Wiernik PH. Near-tetraploid clones in acute leukemia. Blood. 1983;61:71-8.
  • Rowley J, Chaganti R, Testa J. Chromosome patterns in human myeloid leukemia. In: McArthur JR, Hillman RS. (eds), Hematology – 1982, pp. 60-63. Thorofare, NJ: American Society of Hematology, 1982.
  • Rowley JD, Testa JR. Chromosome abnormalities in malignant hematologic diseases. Adv Cancer Res. 1982;36:103-48.
  • Gallagher, RE, Ferrari, AC, Zulich, AW, Testa, JR. Variable differentiative response of 6-thioguanine-resistant HL60 sublines: possible relationship to double minute chromosomes. Prog Nucleic Acid Res Mol Biol. 1983;29:283-6.
  • Testa JR, Jumamoy LM, Wiernik PH. Variant Philadelphia chromosome translocations in two patients with chronic myelogenous leukemia. Cancer Genet Cytogenet 1982;7:79-84.
  • Larson RA, Sweet DL, Golomb HM, Testa JR, Rowley JD. Response to 5 azacytidine in patients with refractory acute nonlymphocytic leukemia and association with chromosome findings. Cancer. 1982;49:2222-5.
  • Golomb HM, Alimena G, Rowley JD, Vardiman JW, Testa JR, Sovik C. Correlation of occupation and karyotype in adults with acute nonlymphocytic leukemia. Blood 1982 60: 404-411.
  • Wong KK Jr, Golomb HM, Rowley J, Baker AL, Testa J, Vardiman J. Prognostic significance of posttransfusion hepatitis and chromosomal abnormalities in adult acute nonlymphocytic leukemia. Cancer Genet Cytogenet. 1982;5:281-92.
  • Testa JR, Rowley JD. Chromosomes in leukemia and lymphoma with special emphasis on methodology. In: Catovsky D. (ed), The Leukemic Cell, pp. 184-202. New York: Churchill Livingstone, 1981.
  • Waghray M, Eques C, Rowley JD, Martin P, Testa JR. Methods of processing marrow samples may affect the frequency of detectable aneuploid cells. Am J Hematol. 1981;11:409-15.
  • Testa JR, Kanofsky JR, Rowley JD, Baron JM, Vardiman JW. Karyotypic patterns and their clinical significance in polycythemia vera. Am J Hematol. 1981 11: 29-45, 1981
  • Eques C, Waghray M, Testa JR, Rowley JD, Cytogenetic analysis of bone marrow and peripheral blood samples stored in fixative for several years. Stain Technol. 5 1981 6: 109-112.
  • Testa JR, Kanofsky JR, Rowley JD, Baron JM. Multiple cytogenetically abnormal clones in two polycythemia vera patients. Hum Genet. 1981;57:165-8.
  • Testa JR, Rowley JD. Chromosomal banding patterns in patients with acute nonlymphocytic leukemia. Cancer Genet Cytogenet. 1980;1:239-47.
  • Testa JR. Cytogenetic patterns in polycythemia vera. Cancer Genet Cytogenet. 1980;1:207-15.
  • Testa JR, Rowley JD, Hawkins C, Yu RL, Aronson MM, Mulivor RA, Greene AE, Coriell LL. A balanced translocation (17;22) and a pericentric inversion of chromosome 5: Repository identification No. GM3196. Cytogenet Cell Genet. 1980;27:270.
  • Streuli RA, Testa JR, Vardiman JW, Mintz U, Golomb HM, Rowley JD. Dysmyelopoietic syndrome: sequential clinical and cytogenetic studies. Blood. 1980;55:636-44.
  • Golomb HM, Rowley JD, Vardiman JW, Testa JR, Butler A. "Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity. Blood. 1980;55: 253-9.
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1970 - 1979

  • Testa JR, Mintz U, Rowley JD, Vardiman JW, Golomb HM. Evolution of karyotypes in acute nonlymphocytic leukemia. Cancer Res. 1979;39:3619-362.
  • Golomb HM, Testa JR, Vardiman JW, Butler AE, Rowley JD. Cytogenetic and ultrastructural features of de novo acute promyelocytic leukemia: The University of Chicago experience (1973-78). Cancer Genet Cytogenet. 1979;1:69-78.
  • Carrano AV, Mayall BH, Testa JR, Ashworth LK, Rowley JD. Chromosomal DNA cytophotometry in 20q- nonspecific myeloid disorders. Cancer Res. 1979;39:2984-7.
  • Testa JR, Rowley JD. Cytogenetic patterns in acute nonlymphocytic leukemia. Virchows Arch. Cell Pathol. 1978;29:65-72.
  • Testa JR, Kinnealey A, Rowley JD, Golde DW, Potter D. Deletion of the long arm of chromosome 20 [del(20)(q11)] in myeloid disorders. Blood. 1978;52:868-77.
  • Golomb HM, Vardiman JW, Rowley JD, Testa JR, Mintz U. Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977). N Engl J Med. 1978;299:613-9.
  • Testa JR, Golomb HM, Rowley JD, Vardiman JW, Sweet DL Jr. Hypergranular promyelocytic leukemia (APL): cytogenetic and ultrastructural specificity. Blood. 1978;52:272-80.
  • Schulz RJ, Nath R, Testa JR. The effects of ultra-high dose rates on survival and sublethal repair in Chinese-hamster cells. Int J Radiat Biol. 1978;33:81-8.
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