Faculty Summaries
Alexei V. Tulin, PhD
Alexei V. Tulin, PhD
Associate Professor
Alexei.Tulin@fccc.edu
Office Phone: 215-728-7408
Office: R362

2014

  • Lodhi N, Kossenkov A, Tulin AV. 2014. Bookmarking promoters in mitotic chromatin: Poly(ADP-ribose)Polymerase-1 as an epigenetic mark. Nucleic Acids Res. 42(11): 7028-7038.
  • Kirsanov KI, Kotova E, Markov P, Golovine K, Lesovaya EA, Kolenko V, Yakubovskaya MG, Tulin AV. 2014. Minor grove binding ligands disrupt PARP-1 activation pathways. Oncotarget. 5: 428-437.
  • Thomas CJ, Kotova E, Andrake M, Adolf-Bryfogle J, Glaser R, Regnard C, Tulin AV. 2014. Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly-ADP-ribosylation. Mol Cell. 53: 831–842.
  • Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM. 2014. Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. British journal of cancer. 110(4): 899-907.

2013

  • Ji Y, Tulin AV. 2013. Posttranscriptional regulation by Poly(ADP-ribosyl)ation. Int J Mol Sci. 14: 16168-16183.
  • Ji Y, Tulin AV. 2013. Alternative Splicing Regulation by Poly(ADP-ribosyl)ation. Nova Science Publishers. New Development in Alternative Splicing Research. pp. 159-170.
  • Ji Y, Jarnik M, Tulin AV. 2013. Poly(ADP-ribose) Glycohydrolase and Poly(ADP-ribose)-interacting Protein Hrp38 Regulate Pattern Formation during Drosophila Eye Development. Gene. 526: 187–194.
  • Thomas C, Tulin AV. 2013. Poly-ADP-Ribose Polymerase: Machinery for Nuclear Processes. Mol Aspects Med. 34(6): 1124-1137.

2012

  • Ji Y, Tulin AV. 2012. Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization. Nat Communications. 3: 760. doi:10.1038/ncomms1759.
  • Boamah EK, Kotova E, Garabedian M, Jarnik M, Tulin AV. 2012. Poly(ADP-ribose) Polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. PLoS Genetics. 8(1):e1002442.
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2011

  • Tulin A. Re-evaluating PARP1 inhibitor in cancer. Nat Biotechnol. 2011;29(12):1078-9.
  • Garabedian M, Jarnik M, Kotova E, Tulin AV. Generating a knockdown transgene against Drosophila heterochromatic Tim17b gene encoding mitochondrial translocase subunit. PLoS One. 2011;6(10):e25945.
  • Lohdi N, Tulin AV. 2011. PARP1 Genomics: Chromatin Immuno-precipitation Approach using Anti-PARP1 Antibody (ChIP and ChIP-seq). Methods Mol Biol. 780: 191-208.
  • Kotova E, Pinnola AD, Tulin AV. 2011. Small-molecule Collection and High-throughput Colorimetic Assay to Identify PARP-1 Inhibitors. Methods Mol Biol. 780: 491-516.
  • Kotova E, Lodhi N, Jarnik M, Pinnola AD, Ji Y, Tulin AV. Drosophila histone H2A variant (H2Av) controls Poly(ADP-Ribose) Polymerase 1 (PARP1) activation in chromatin. Proc. Natl. Acad. Sci. U. S. A. 2011;108(15): 6205-6210.
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2010

  • Zaret KS, Caravaca JM, Tulin A, Sekiya T. Nuclear Mobility and Mitotic Chromosome Binding: Similarities between Pioneer Transcription Factor FoxA and Linker Histone H1. Cold Spring Harb Symp Quant Biol. 2010;75:219-26.
  • Tikhmyanova N, Tulin AV, Roegiers F, Golemis EA. Dcas Supports Cell Polarization and Cell-Cell Adhesion Complexes in Development. PLoS One. 2010 Aug 24;5(8). pii: e12369.
  • Ji Y, Tulin AV. 2010. The roles of PARP1 in gene control and cell differentiation. Review for Curr. Opin. Genet. Dev. 20(5):512-518.
  • Kotova E, Jarnik M, Tulin AV. Uncoupling of the trans-activation and trans-repression functions of PARP1 protein. Proc Natl Acad Sci U S A. 2010;107(14):6406-11.
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2009

  • Ji Y, Tulin AV. Poly(ADP-ribosyl)ation of Heterogeneous Nuclear Ribonucleoproteins Modulates Splicing. Nucl. Acids Research. 2009;37:3501-13.
  • Sekiya T, Muthurajan UM, Luger K, Tulin AV, Zaret KS. Nucleosome-Binding Affinity as a Primary Determinant of the Nuclear Mobility of the Pioneer Transcription Factor FoxA. Genes Dev. 2009;23:804-809.
  • Kotova E, Jarnik M, Tulin AV. Poly (ADP-ribose) Polymerase 1 is required for protein localization to Cajal body. PLoS Genetics. 2009;5(2):e1000387.
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2008-1997

  • Sala A, La Rocca D, Burgio G, Kotova E, Di Gesù D, Collesano M, Ingrassia A, Tulin AV, Corona DFV. The Nucleosome Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation. PLoS Biology. 2008;6(10):e252.
  • Pinnola AD, Naumova N, Shah M, Tulin AV. Nucleosomal core histones mediate dynamic regulation of PARP1 protein binding to chromatin and induction of PARP1 enzymatic activity. J Biol Chem. 2007;282:32511-9.
  • Tulin A, Naumova N, Menon A, Spradling A. The Drosophila Poly(ADP-ribose) Glycohydrolase (Parg) protein mediates chromatin structure and Sir2-dependent silencing. Genetics. 2006;172:363-371.
  • Tulin A, Chinenov Y, Spradling A. Regulation of chromatin structure and gene activity by Poly(ADP-ribose) polymerases. Curr Top Devel Biol. 2003;56:55-83.
  • Kogan GL, Tulin AV, Aravin AA, Abramov YA, Kalmykova AI, Maisonhaute C, Gvozdev VA. The GATE retrotransposon in Drosophila melanogaster: mobility in heterochromatin and aspects of its expression in germline tissues. Mol Genet Genomics. 2003;269(2):234-42.
  • Tulin A, Spradling A. Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science. 2003;299(5606):560-2.
  • Tulin A, Stewart D, Spradling AC. The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev. 2002;16(16): 2108-19.
  • Gvozdev VA, Aravin AA, Abramov YA, Klenov MS, Kogan GL, Lavrov SA, Naumova NM, Olenkina OM, Tulin AV, Vagin VV. Stellate repeats: targets of silencing and modules causing cis-inactivation and trans-activation. Genetica. 2003;117(2-3):239-45.
  • Aravin AA, Naumova NM, Tulin AV, Vagin VV, Rozovsky YM, Gvozdev VA. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr Biol. 2001;11(13):1017-27.
  • Gvozdev VA, Kogan GL, Tulin AV, Aravin AA, Naumova NM, Shevelyov YY. Paralogous stellate and Su(Ste) repeats: evolution and ability to silence a reporter gene. Genetica. 2000;109(1-2):131-40.
  • Aravin AA, Naumova NM, Tulin AV, Klenov MS, Gvozdev VA. [The study of interaction between paralogous tandem repeats stellate and suppressor of stellate in the genome of Drosophila melanogaster] Genetika. 2000;36(4):581-4.
  • Erist LK, Kosorukov VS, Antipova TA, Chupina IuM, Tulin AV, Lavrov SA, Bashkirov VN, Gvozdev VA, Brem G, Korochkin LI. [Preparation of transgenic house flies Musca domestica] Dokl Akad Nauk. 1999;367(3):430-2.
  • Tulin AV, Naumova NM, Aravin AA, Gvozdev VA. Repeated, protein-encoding heterochromatic genes cause inactivation of a juxtaposed euchromatic gene. FEBS Lett. 1998;425(3):513-6.
  • Benevolenskaya EV, Kogan GL, Tulin AV, Philipp D, Gvozdev VA. Segmented gene conversion as a mechanism of correction of 18S rRNA pseudogene located outside of rDNA cluster in D. melanogaster. J Mol Evol. 1997;44(6):646-51.
  • Tulin AV, Kogan GL, Filipp D, Balakireva MD, Gvozdev VA. Heterochromatic Stellate gene cluster in Drosophila melanogaster: structure and molecular evolution. Genetics. 1997;146(1):253-62.
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