Faculty Summaries
Hong Yan, PhD
Hong Yan, PhD
Associate Professor
Office Phone: 215-728-2514
Fax: 215-728-3616
Office: R304

Original Articles

  • Fazlieva R, Spittle CS, Morrissey D, Hayashi H, Yan H, Matsumoto Y. Proofreading exonuclease activity of human DNA polymerase and its effects on lesion-bypass DNA synthesis. Nuclei Acids Res. 2009;37:2854-66. PubMed
  • Liao S, Toczylowski T, Yan H. Identification of the Xenopus DNA2 protein as a major nuclease for the 5' -> 3' strand-specific processing of DNA ends. Nucleic Acids Res. 2008;36:6091-100. PubMed
  • Liao SR, Matsumoto Y, Yan H. Biochemical Reconstitution of Abasic DNA Lesion Replication in Xenopus Extracts. Nucleic Acids Research. 2007;35:5422-9. PubMed
  • Toczylowski T, Yan H. Mechanistic analysis of a DNA end processing pathway mediated by the Xenopus Werner syndrome protein. J Biol Chem. 2006;281:33198-33205. PubMed
  • Yan H, McCane J, Toczylowski T, Chen C. Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair. J Cell Biol. 2005;171:217-227. PubMed
  • Chen CY, Graham J, Yan H. Evidence for a replication function for FFA-1, the Xenopus ortholog of Werner syndrome protein. J. Cell Biol. 152:985-996, 2001. PubMed
  • Liao SR, Graham J, Yan H. The Function of Xenopus Bloom's Syndrome Protein Homolog (xBLM) in DNA Replication. Genes & Development. 2000;14:2570-5. PubMed
  • *Yan H, Chen CY, Kobayashi R, Newport J. Replication focus-forming activity 1 and the Werner's syndrome gene product. Nature Genetics. 1998;19:375-8. *corresponding author. PubMed
  • *Young MR, *Suzuki K, *Yan H, Gibson S, Tye BK. Nuclear accumulation of S. cerevisiae Mcm3 is dependent on its nuclear localization sequence. Genes to Cells. 1997;2:631-43. *equal contributions. PubMed
  • Newport J, Yan H. Organization of DNA into foci during replication. Current Opinion in Cell Biology. 1997;8:365-8. PubMed
  • Hua X, Yan H, Newport J. A role for Cdk2 kinase in negatively regulating DNA replication during S-phase of the cell cycle. Journal of Cell Biology. 1997;137:183-92. PubMed
  • Yan H, Newport J. FFA-1, a protein that promotes the formation of replication centers within nuclei. Science. 1995;269:1883-5. PubMed
  • Yan H, Newport J. An analysis of the regulation of DNA synthesis by cdk2, cip1, and licensing factor. Journal of Cell Biology. 1995;129:1-15. PubMed
  • Yan H, Merchant M, Tye B-K. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes & Development. 1993;7:2149-60. PubMed
  • Yan H, Gibson S, Tye B-K. Mcm2 and Mcm3, two yeast proteins important for ARS activity, are similar in structure and function. Genes & Development. 1991;5:944-57. PubMed